Gene Information

Name : TOPB45_0145 (TOPB45_0145)
Accession : YP_004627189.1
Strain : Thermodesulfobacterium geofontis OPB45
Genome accession: NC_015682
Putative virulence/resistance : Unknown
Product : adenine-specific DNA methyltransferase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : 2.1.1.72
Position : 135347 - 136876 bp
Length : 1530 bp
Strand : +
Note : KEGG: mja:MJECL42 type I restriction system protein M; PFAM: DNA methylase, adenine-specific

DNA sequence :
ATGAAGGAAAAGGACTTGATTTTTGAGGATAAGTTATGGAAAGCTGCTGATAAGTTGCGAAAAAAAGTGGAGGTTCACGA
ATATAAGTATATAGTTTTAGGATTAATATTTTTAAGATATCTTTCCTTTGCTTTTGAAGAAAAAAGAAAAGAGATAGAAG
AAAAAGAGGCTAAGCATTTTCCCGAAGATTTAAGATTTAAAGTTTGTGAAGATAGAGATTTTTACATGGCTAACGGAACT
CTTTACGTTCCGGAGAAGGCTCGTTGGGATTACATTCGAAAGAACGCTAATCAGCCAAACATAGGTGAAATAATCGACCA
AGCTATAGAAATCTTGGAAAATGAATATCCTAAGCAATTAAAAGATGTGATACCTAAGATCTACTCTCGCGTCAATCTTG
ATAGCCACGATTTTGCCTATTTAATCAACCTCTTTTCCCAAATTCATTTTGGTAAAGATCATCAGGCAAAAGACATTTTT
GGTAGGATTTATGAATATTTTCTTGGGAAATTTACTGAAGCAGAGGGTAAAAAGGGTGGAGAATTTTATACCCCAAGGTC
TTTAACCAGGCTTATCGTTGAGATTTTAGATGTAAAGGAGGGGCGTATTTTTGACCCTGCTTGTGGTTCAGGTGGCTTTT
TTATTTCAGCCTTAGAGAAATTACAAAGAGAGGGGATAGGAAATGAGCGGTTGTCCATCTACGCACAAGAGTCCAAGGAG
TTTGTTTGGAAGGTTTGTAAAATGAATTTAGCCATAAGAGGAGTTGAAGGAGATATACGATGGGGAGATTCTTACCATGA
TGATAAATTCTTTGACCTAAGGGCTGACTATATCGTTTCCAATCCTCCCTTTAATGACAGCGAATGGGGAAGGGATAGAG
TTAAACCAAACGACCCGAGGTTTAAGTATGGGCTTCCTCCTGAAAACAACGCAAATTATGTTTGGATCCAGCATTATATC
TATCATCTTGCCCCAAACGGCAAGGCTGGCTTTGTTATGGCAAATGGAGCCTTGTCCGTAGGAGGAGTAGAAGGTGAAAT
CAGAAGAAAGATCATTCAGGATGATTTAATATATGGAATAATAGCTACACCACCCAAGATGTTCTATACCGTCTCTTTAC
CCGCTTCTTTATGGTTTATTAGAAAAACGAAGCCTGAACATATGAAGGGTAAGATCTTGTTTATCTATGCTAAAAAGATG
TATAAGTCTATTTCAAGGAAGCAAAACATCTTTACCGAAGAGCACATAGCCAAAATTGTAGAAAAGTTTAGGAAGTTTGA
ACGGGGAGAGCCTGAGGAAATGATAAACGAGGTCGGCTTTGCAAAGGTTGCCACTTTAGAAGAGGTTGCTAAAAATGGCT
ATGTTTTAACTCCGGGAAGGTATGTAGGAATAAAGCTTGACGAAGAGGATATATCTTTTGAAGAGAAAATGAGCCAATAT
TCAAAAGAGCTTTCAGAATTGCTAAGAAAAGAGGCAGAACTAACTGAAAAAATACGAGAGGTGTTTAAAAGCTTAGGATG
GGAGGTATAG

Protein sequence :
MKEKDLIFEDKLWKAADKLRKKVEVHEYKYIVLGLIFLRYLSFAFEEKRKEIEEKEAKHFPEDLRFKVCEDRDFYMANGT
LYVPEKARWDYIRKNANQPNIGEIIDQAIEILENEYPKQLKDVIPKIYSRVNLDSHDFAYLINLFSQIHFGKDHQAKDIF
GRIYEYFLGKFTEAEGKKGGEFYTPRSLTRLIVEILDVKEGRIFDPACGSGGFFISALEKLQREGIGNERLSIYAQESKE
FVWKVCKMNLAIRGVEGDIRWGDSYHDDKFFDLRADYIVSNPPFNDSEWGRDRVKPNDPRFKYGLPPENNANYVWIQHYI
YHLAPNGKAGFVMANGALSVGGVEGEIRRKIIQDDLIYGIIATPPKMFYTVSLPASLWFIRKTKPEHMKGKILFIYAKKM
YKSISRKQNIFTEEHIAKIVEKFRKFERGEPEEMINEVGFAKVATLEEVAKNGYVLTPGRYVGIKLDEEDISFEEKMSQY
SKELSELLRKEAELTEKIREVFKSLGWEV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 3e-99 44
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 3e-100 44
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 3e-98 43