Gene Information

Name : Thein_1578 (Thein_1578)
Accession : YP_004626402.1
Strain : Thermodesulfatator indicus DSM 15286
Genome accession: NC_015681
Putative virulence/resistance : Unknown
Product : adenine-specific DNA-methyltransferase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : 2.1.1.72
Position : 1640992 - 1642680 bp
Length : 1689 bp
Strand : -
Note : COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR002296:IPR002052:IPR003356; KEGG: chl:Chy400_1958 N-6 DNA methylase; PFAM: N-6 DNA methylase; PRIAM: Site-specific DNA-methyltransferase (adenine-specific); SPTR:

DNA sequence :
ATGCCAAACAAGAATCCTATCGACAAATTCCTCCAAGAAGATCTTGGTCTTGAGTTAAACAGCCAATCTCAAGGAAAACA
AAAACCCCAAAGACGTTCTCGTCGTACCCAAAAGGTCGAGGTAAACGACAGGGCACTTCTCGGTTTTGAAGCCAAGCTCT
GGGAGGCAGCCAACGCCCTGCGGGGAAGTATGGACGCCGCCGAGTACAAACACGTGGTCCTAGGGCTGATCTTCCTCAAG
TACATCTCGGACGCTTTCGAGGAACATCGCAAACGACTTGAACAGGAACCTTACGCCGATCCTGAAGATCCCGACGAGTA
TCGGGCGGCCAACGTCTTCTGGGTGCCGCCAGAGGCCCGCTGGGAGCGTCTCAAGCAAAACGCCCGTCGGCCAGAGATCG
GCCAGATAGTGGACGAGGCCATGGAGGCCTTAGAGCGCGAGAATCCTTCCCTAAAAGGAGTGCTTCCTAAAGATTATGCT
CGCCCGGCCCTGGATAAACAGCGCCTTGGTCAACTCATAGATCTGATTACGAATATCCGGTTAGAGGGCGAAGAAGCGCG
GGGAAAGGACGTTCTGGGGCGGGTTTACGAATATTTTCTTGGCCAGTTTGCCAGCGCCGAAGGCCGCAAAGGGGGTGAAT
TTTACACTCCGGCTTCGGTGGTAAAGCTTCTTGTGGAGATGCTTGAGCCTTTTGAGGGCCGGGTTTACGACCCTTGCTGT
GGCTCTGGCGGCATGTTTGTGCAGTCGGTGCGTTTTGTGGAGGCCCACGCCACGGGCAACGGTAACGGCGGCCGGGCCCG
CGCCCGCATCAGCATCTACGGCCAGGAACTTAATTACACTACCTGGCGTCTCTGTAAAATGAATCTCGCCATCCGTGGCA
TAGAGGGAAAGATCGAACAAGGCGACACCTTTTTGAATGACCGGTTCCCTGATCTCAAAGCCGATTACATCCTGGCCAAT
CCACCTTTCAATATGAAAAACTGGGGCGCAGAACAACTCCGCCACGACAAACGCTGGAAATATGGGCTTCCGCCGGCGAG
AAACGCCAACTTTGCCTGGCTACAGCACATGATCCATCATCTATCACCAGTAGGTTACGCCGGGGTGGTGCTCGCCAACG
GCTCGCTTTCTTCCAATCAGTCAAACGAAGGAGAGATTCGCAAGAATATCGTGGAAGCCGACCTGGTGGACTGCATCGTG
GCCCTGCCTGATAAACTTTTTTACACCACCCAGATCCCGGCCTGCCTGTGGTTTCTGACCAGGGACAAGAGCGGTCGCCC
GCCTGCCGGGCAGAAGAAGCGTCTTCGTGACCGCCGTGGAGAAGTCCTTTTCATTGACGCCCGCAAGATGGGAGTCATGG
TGGATCGCGTCCATAGAGAACTTACAGATGAAGAAATCGAGAAAATTGCCCGGACATACCACGCCTGGCGCGCTGAAGAT
GGTGCTGGTGAGTATAAAGACATCCCTGGATTCTGCATAAGTGCGACTATAGAGAAAATCCGCAGGGAGCACGACTACAT
ACTCACCCCGGGCCGCTATGTGGGTGTAGAGATTCAGGAAGAAGACGACGAAATTTTTGAGGAGAAGATGAAGCGCCTGG
TGGCGGAGCTTGAGGCCCAGTTTTCCGAAGGGGCAAAACTTGAAGAGGCCATTAAACGTAATTTAAGGGAGCTTGGGTTT
GGAGAATAG

Protein sequence :
MPNKNPIDKFLQEDLGLELNSQSQGKQKPQRRSRRTQKVEVNDRALLGFEAKLWEAANALRGSMDAAEYKHVVLGLIFLK
YISDAFEEHRKRLEQEPYADPEDPDEYRAANVFWVPPEARWERLKQNARRPEIGQIVDEAMEALERENPSLKGVLPKDYA
RPALDKQRLGQLIDLITNIRLEGEEARGKDVLGRVYEYFLGQFASAEGRKGGEFYTPASVVKLLVEMLEPFEGRVYDPCC
GSGGMFVQSVRFVEAHATGNGNGGRARARISIYGQELNYTTWRLCKMNLAIRGIEGKIEQGDTFLNDRFPDLKADYILAN
PPFNMKNWGAEQLRHDKRWKYGLPPARNANFAWLQHMIHHLSPVGYAGVVLANGSLSSNQSNEGEIRKNIVEADLVDCIV
ALPDKLFYTTQIPACLWFLTRDKSGRPPAGQKKRLRDRRGEVLFIDARKMGVMVDRVHRELTDEEIEKIARTYHAWRAED
GAGEYKDIPGFCISATIEKIRREHDYILTPGRYVGVEIQEEDDEIFEEKMKRLVAELEAQFSEGAKLEEAIKRNLRELGF
GE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 4e-150 59
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 3e-149 59
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 3e-149 59
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 4e-119 49