Gene Information

Name : Thein_1137 (Thein_1137)
Accession : YP_004625971.1
Strain : Thermodesulfatator indicus DSM 15286
Genome accession: NC_015681
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 1205992 - 1207695 bp
Length : 1704 bp
Strand : -
Note : COGs: COG0804 Urea amidohydrolase (urease) alpha subunit; InterProIPR017950:IPR005848:IPR017952:IPR011612:IPR 006680:IPR017951; KEGG: tjr:TherJR_0607 urease, alpha subunit; PFAM: amidohydrolase; Urease alpha-subunit domain-containing protein; PRIAM: Ureas

DNA sequence :
ATGAAAATAGACAGAAAAAAATACGCAGAACTTTATGGACCAACTGTTGGAGACAAAATTAGACTAGGTGATACAGAATT
GATAATTGAAATAGAAAAAGATTTTACTACTTATGGAGAAGAAGTTGTATTCGGAGCTGGTAAAAATATTAGAGATGGCA
TGGGACAGACTAATACTAAAATAGATGCACCAGATTTAGTTATCACCAATGTTATCATTTTAGATTATACAGGCATTGTA
AAAGCTGATATAGGAATAAAAAACGGCTATATTTGTGGCATAGGTAAAGCAGGTAATCCTGATACTATGGATAACGTTAC
TCCTGGATTGGAAATAGGTCCGTTCACAGAGATAATTTCCGGGGAAGGCTTAATTGCTACAGCGGGAGCAGTTGATAAGC
ACGTACATTTTATTTCTCCTCAAATTGTCTACGAAGCCCTTTCAAATGGAGTTACTACTTTAATAGGGGGTGGAGACGGA
CCTACCACTGGTACTAATGCTACCAATGCTACTCCGGGCCCTTGGAATATTCATCGTATGTTAGAGGCTATTGAAGAGTT
TCCCGTCAACATTGGTCTAATTGGTAAGGGAAATTCTTCTAATCCCAAAATGCTAATAGAACAGTTAAAAGAAGGAGCAA
TGGGTTTTAAAATTCACGAGGATTGGGGCGCCACACCGAATGTCATAGATGTAGTTTTAGATGTGGCTGATGAATATGAT
GTAATGGTAGCCTTACATACCGATACTCCAAATGAAGCTGGGTATGTTGAAAATACTATCGCTAGCTTAAAAGGGAGAAC
AATTCATACTTATCATAGTGAAGGAGCAGGTGGTGGTCACGCCCCAGATATTTTACGAATTGCTGGCTTGCCAAATGTTT
TACCCTCTTCTACAACTCCGACTTTACCAGCTACTATAAATACTGTTACAGAACATGTAGATATGTTGATAGTCTGTCAT
CATCTCAAGCCCGAAGTTCCAGAAGACGTAGCCTTTGCTAAGTCTAGAATAAGAGCCCAAACTATTCTTGCTGAAGATGT
CTTGCATGATATGGGCGTTATAAGCATAGTTTCTTCCGATTCTCAAGCTATGGGAAGAATTGGAGAAACAGTTCTGCGTA
CCTGGCAAATGGCTCACTCGATGAAAGTACAAAGAGGTAAATTACCAGAAGATTCTGAAGGCAATGATAATTTTAGAGTT
AAAAGATATATTGCCAAATATACTATAAATCCTGCTATTGCTTGTGGAGTATCTAAATATGTTGGTAGTATTGAGCCGGG
GAAGCTAGCGGACATTGTCCTTTGGGATCCCAAGTTTTTTGGAGTAAAACCAAGCTTAGTATTAAAAAGTGGTTTTGTTG
TTTGGTCACTTATGGGTGATGCCAACGCTTCTATTCCAACTTGCGAACCATATATGTATAAACCAATGTTTGGATCTTTT
GGTAAGGCAAGGCAGACGTTATCACTAACTTTTGTTTCAAAATTAGCTTACGAGAATGACATCAAAAACAAATTGAAGTT
GAATAGGCAATTTAAACCTGTTGAAGAATGTCGTCAAATAGGAAAGAAAAACATGATATTTAACGATTTTGTAGGAGAAG
TTTATGTAGATCCTAAGACTTATGAAGTTTTCGTCAATGGTACGAAAATCGAATCAAATTTCATGAAAGAGTTGCCATTA
GCCCAACGTTATTTTCTATTTTAG

Protein sequence :
MKIDRKKYAELYGPTVGDKIRLGDTELIIEIEKDFTTYGEEVVFGAGKNIRDGMGQTNTKIDAPDLVITNVIILDYTGIV
KADIGIKNGYICGIGKAGNPDTMDNVTPGLEIGPFTEIISGEGLIATAGAVDKHVHFISPQIVYEALSNGVTTLIGGGDG
PTTGTNATNATPGPWNIHRMLEAIEEFPVNIGLIGKGNSSNPKMLIEQLKEGAMGFKIHEDWGATPNVIDVVLDVADEYD
VMVALHTDTPNEAGYVENTIASLKGRTIHTYHSEGAGGGHAPDILRIAGLPNVLPSSTTPTLPATINTVTEHVDMLIVCH
HLKPEVPEDVAFAKSRIRAQTILAEDVLHDMGVISIVSSDSQAMGRIGETVLRTWQMAHSMKVQRGKLPEDSEGNDNFRV
KRYIAKYTINPAIACGVSKYVGSIEPGKLADIVLWDPKFFGVKPSLVLKSGFVVWSLMGDANASIPTCEPYMYKPMFGSF
GKARQTLSLTFVSKLAYENDIKNKLKLNRQFKPVEECRQIGKKNMIFNDFVGEVYVDPKTYEVFVNGTKIESNFMKELPL
AQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-151 62
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-151 62
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 3e-151 62
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-151 62
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 5e-148 61
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 5e-148 61

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Thein_1137 YP_004625971.1 urease subunit alpha VFG0270 Protein 6e-147 59