Gene Information

Name : Mzhil_1432 (Mzhil_1432)
Accession : YP_004616495.1
Strain : Methanosalsum zhilinae DSM 4017
Genome accession: NC_015676
Putative virulence/resistance : Unknown
Product : adenine-specific DNA-methyltransferase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : 2.1.1.72
Position : 1542768 - 1544300 bp
Length : 1533 bp
Strand : +
Note : COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR002052:IPR003356:IPR002296; KEGG: mhu:Mhun_2789 N-6 DNA methylase; PFAM: N-6 DNA methylase; PRIAM: Site-specific DNA-methyltransferase (adenine-specific); SPTR: B4

DNA sequence :
ATGGCTAAATCAACCAATAATAATGGCAGAACTCTTGAACAAAAGCTATGGGAAGCTGCTGATAAATTACGAAACAATAT
TGACGCTGCAGAATACAAGCATGTTGTCCTGGGCCTGATCTTTATTAAATATATATCCGATTCTTTTGTAGAATTATATC
AGGAATTAGAAGCAGATGAAGATTCGGATCCCGAAGATATTGATGAATATATTGCAAGGAATATTTTCTGGGTTCCTAAA
GAGTCCCGCTGGGAAAATATTGTAGCCGATGCCAGAAATTCAACTATTGGAACTACAATAGACAATGCAATGAGACAACT
CATGAAAAACAATGAGAGTCTAACCGGTATTTTACCTACAAATTACGGAAGACCAGAACTTGATAAACACAAACTTGGAG
AACTTGTAGATATTATTCATTCAATTGAATTCGATGAATCAAAAGAAAGTGAACGTGATGTTCTTGGTCGAGTTTATGAA
TATTTCCTGGGTAACTTTGCTAGTGCTGAAGGTAAAAAAGGGGGAGAGTTCTATACTCCCAGTTGTGTTGTAAAAACTCT
GGTTGAAATGATAGAGCCATTTAATGGTAGAGTCTATGATCCATGTCATGGTTCAGGTGGTATGTTCGTGCAAAGTAGAA
GATTTGTTGAACAACATGGAGGTACTGACCAGGATATCTATGTCTATGGTCAGGAATCTAACCCGACCACATGGAAATTG
TGTAAAATGAATCTCGCCCTGCACGGCATCGATAATGATGTGAGAATGGGGGACACGTTTCGAGAGGATAAGCATCCTAA
CCTGAAAGTAGATTACATACTCGCAAATCCACCATTCAATATAAGTGACTGGGGCGGTGAAAATCTACAGGAAGATGTCA
GGTGGAAATACGGAGTTCCTCCCAAAGGCAATGCGAATTATGCATGGATTCAGCATATGATATATCACCTGAAACCAACT
GGTATTGCAGGGTTCGTTTTAGCTAATGGATCACTTTCGTCCAATACTTCTGGTGAAGGTGAGATTCGGAAAAATATACT
TGAAGATGATTTAGTTGACTGTATTATTGCAATGCCTGGACAGCTGTTTTACAACACAGGAATTCCGTGTTGTCTCTGGT
TCGTTACACGTGATAAAAAGAATCACCGGTTTAGAGACAGGAGAGGTGAAGTGCTGTTAATAGACGCCAGAAATATGGGT
GTAATGGTAGATCGAACACACCGAGAACTCACGAATGAAGATATTAAGAAAATCGCTGATACTTATCATGCATGGCGTGG
TGAACCTGATACTGGTGAATATGAAGATGTTGCAGGATTCTGTAAGTCTGCTACACTTGATGATATACGAAAACACGACT
ATGTACTAACTCCAGGAAGATATGTGGGATTTGCAGATGAGGAAGAAGATGATGAACCATTTGAGGAGAAAATGGAACGA
TTGACTTCACAGTTATCGGAGCAATTTAAAAAGTCCAATGAACTTGAGGATAAAATTAGAGACAACCTGAGGGAGATTGG
ATATGAGTTATGA

Protein sequence :
MAKSTNNNGRTLEQKLWEAADKLRNNIDAAEYKHVVLGLIFIKYISDSFVELYQELEADEDSDPEDIDEYIARNIFWVPK
ESRWENIVADARNSTIGTTIDNAMRQLMKNNESLTGILPTNYGRPELDKHKLGELVDIIHSIEFDESKESERDVLGRVYE
YFLGNFASAEGKKGGEFYTPSCVVKTLVEMIEPFNGRVYDPCHGSGGMFVQSRRFVEQHGGTDQDIYVYGQESNPTTWKL
CKMNLALHGIDNDVRMGDTFREDKHPNLKVDYILANPPFNISDWGGENLQEDVRWKYGVPPKGNANYAWIQHMIYHLKPT
GIAGFVLANGSLSSNTSGEGEIRKNILEDDLVDCIIAMPGQLFYNTGIPCCLWFVTRDKKNHRFRDRRGEVLLIDARNMG
VMVDRTHRELTNEDIKKIADTYHAWRGEPDTGEYEDVAGFCKSATLDDIRKHDYVLTPGRYVGFADEEEDDEPFEEKMER
LTSQLSEQFKKSNELEDKIRDNLREIGYEL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 1e-152 62
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 6e-153 62
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 5e-152 61
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 2e-116 48