Gene Information

Name : dhbE (MLP_27450)
Accession : YP_004573162.1
Strain : Microlunatus phosphovorus NM-1
Genome accession: NC_015635
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 6.3.2.-
Position : 2955944 - 2957605 bp
Length : 1662 bp
Strand : +
Note : -

DNA sequence : 
GTGACCAGGAGTCCTCTCCGACCAGTCGTCGGCTGGCCCGCCGAGTTCGCCGAGCGCTATCGCGCTGCCGGCTACTGGAC
CGACGAGACCTTCGACGCCTTTCTGGCCGAGCGGGTCCGGCGGTTTGCCGACCGCATCGCGGTCGTGGGCGTCGGCGCCG
CACACCCGCGGGAACGGGTCGCACTCAGCTATGCCGAGCTCGATGCGGCCGTCGGCCAACTGGCTGGGCTGCTGGCCGCG
GCTGGAGTCGAGCGGCGCGACCGGGTCGTGCTGCAGCTGCCGAACTGCGTCGAATATGTCGTCGCGGTGTTCGCCGCCTT
CCGGCTGGGGGCGCTGCCCGTGTTCGCACTGCCGGCCCACCGGGAGCGGGAGATCGGCCAGTTCGCGCGGATCAGCGACG
CAGCCGCGTACGTGTTCGCCGGAAAGGGCTGGGGCTTCGACTATGCGGCTCTCGCCGAGCGGGTGGCGGCTGACCTCCAA
GCGAATGGTCACCAACCGCCGGCCGCGGTCGATCTGTCCAGCTGGAATCTCACCGGTCCGGGTCCGTATCCCAGCATCGT
GACTGCGCCAGCGGTCGAGGCGACCGACATCGCCTTCCTGCAGATGTCCGGCGGGACCACCGGGGTGCCCAAGCTGGTGC
CGCGCACGCACGCCGACTATCTCTACTCGGTGCGTGCCTCGGCCGACATCTGCGATCTGGACGAGACCACCGTGATGCTG
GTCGCGCTGCCTGCCGCACACAACTTCCCGATGAGCTCCCCCGGCCTGCTCGGCGTGCTCGACCGGGGCGGCACCGTGGT
GCTGGCGCCCGACCCGAGCCCGCGGACCTGCTTCGGCATGATCGAGTCCGAGCGGGTGACCCTCACCTCCTTGGTGCCGC
CGTTGGCACAGTCCTGGCTGGCCAGTGCCGCTCGGGGGCTGCGACACGATCTGTCCAGCCTCGAGGTGGTCCAGGTCGGC
GGTGCCCGGCTGGCCGACAGCGTTGCCCGGCGGATCGCTCCCGAGCTCGGCTGCTCGCTGCAGCAGGTGTACGGGATGGC
CGAGGGTCTGGTCTGCTACACCCGCGCCGACGATCCGGACGAATTGGTCACCACCAGTCAGGGTCGGCCGATCAGCTCCG
ATGACGAGTTGCGGATCGACCCCGAGACCGGCGAGCTGGCGACCCGCGGGCCGTACACGATCCGTGGCTACTACGGCGCC
GACGAGGTGCATGTCGACCACTTCACCGACGACGGCTTCTATCGAACCGGCGATGTGGTCCGTCAGCTGCCCAGCGGGCA
TCTGCAGGTGACCGGCCGGATCAAGGACCAGATCAACCGGGGCGGCGACAAGATCGCCATCGACGAGGTCGAGGACCTGC
TGCTGCAATACGACGGCATTCACGACGCCGCCATCGTCTCGGTGCCCGACGCCTATCTCGGCGAACGGGTCTGTGCCTAT
GTGGTGCCGAAGGCACCCAGTTCGGAGAGCGGGCCAGGGGCAACCGATCGAGAGCCCACCCTGGCCGAGATCCGCGCCTT
CCTGACCGCCGCCGGACTCGCCCCCTACAAGCAGCCCGACGAGCTGCGCATCGTCGCCGCGTTCCCGGCCACCGCGCCCG
GCAAGGTCAACCGCCGCCGGCTGCGTGCCTCGCTCGCTGCCTCGGTACCCGCCACTCAGTGA

Protein sequence : 
MTRSPLRPVVGWPAEFAERYRAAGYWTDETFDAFLAERVRRFADRIAVVGVGAAHPRERVALSYAELDAAVGQLAGLLAA
AGVERRDRVVLQLPNCVEYVVAVFAAFRLGALPVFALPAHREREIGQFARISDAAAYVFAGKGWGFDYAALAERVAADLQ
ANGHQPPAAVDLSSWNLTGPGPYPSIVTAPAVEATDIAFLQMSGGTTGVPKLVPRTHADYLYSVRASADICDLDETTVML
VALPAAHNFPMSSPGLLGVLDRGGTVVLAPDPSPRTCFGMIESERVTLTSLVPPLAQSWLASAARGLRHDLSSLEVVQVG
GARLADSVARRIAPELGCSLQQVYGMAEGLVCYTRADDPDELVTTSQGRPISSDDELRIDPETGELATRGPYTIRGYYGA
DEVHVDHFTDDGFYRTGDVVRQLPSGHLQVTGRIKDQINRGGDKIAIDEVEDLLLQYDGIHDAAIVSVPDAYLGERVCAY
VVPKAPSSESGPGATDREPTLAEIRAFLTAAGLAPYKQPDELRIVAAFPATAPGKVNRRRLRASLAASVPATQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 5e-83 42
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-82 42
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-83 42
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 7e-83 42
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-83 42
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-83 42
ybtE CAA21394.1 - Virulence HPI Protein 7e-83 42
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 5e-83 42
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-82 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
dhbE YP_004573162.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 4e-104 47
dhbE YP_004573162.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 4e-92 44
dhbE YP_004573162.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 1e-85 43