Gene Information

Name : guaA (SGPB_0911)
Accession : YP_004559074.1
Strain : Streptococcus pasteurianus ATCC 43144
Genome accession: NC_015600
Putative virulence/resistance : Unknown
Product : bifunctional GMP synthase/glutamine amidotransferase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 950871 - 952433 bp
Length : 1563 bp
Strand : +
Note : functional classification: COG0518(F),COG0519(F)

DNA sequence :
ATGACTGACAATTCTAGTTTGAATAATGTTCAAAAAATCATTGTTCTTGATTATGGTAGCCAGTACAACCAATTGATTGC
ACGTCGTATCCGTGAATTTGGTGTGTTCTCAGAATTGAGAAGCCACAAAATCACAGCAGAAGAAGTGCGCGAGATTAACC
CAATTGGTATCGTACTTTCAGGTGGTCCAAATTCAGTTTATGCTGACAATGCCTTTGGTATTGATGAAGAAATTTTTGAA
TTGGGTATTCCAATTCTTGGTATCTGCTATGGTATGCAATTGTTGACTGATAAACTTGGTGGTAAAGTTGTTCCAGCAGG
TCAAACTGGTAACAGCGAATATGGTCAATCAACACTTCGCTTAAAAGCAAATTCAAAATTATTTGCTGACACACCAGAGA
AACAAACCGTTTTAATGAGCCACGGTGATGCAGTTACCGAAATTCCAGCAGGTTTCCACCTTGTTGGCGATTCTGCTGAT
TGCCCTTACGCAGCCATTGAAAATACTGAGAAAAACATTTATGGTATCCAATTCCACCCAGAAGTTCGTCACTCAGTATA
TGGTAATGATATTTTACGTAACTTTGCTTTCAAGATTTGCGGAGCTAAAGGTGATTGGTCAATGGACAACTTCATTGAGT
TGCAAATTTCTGAGATCCGCAAAAAAGTTGGAAACCGTAAAGTTCTTCTAGGGCTTTCAGGTGGTGTTGATTCATCAGTT
GTTGGTGTTCTTCTTCAACGTGCTATCGGTGACCAATTGACATGTATCTTCGTTGACCACGGTCTTCTTCGTAAAGGAGA
AGGGGACCAAGTTATGAATATGCTTGGTGGTAAATTCGGATTGAACATCATTCGTGTTGATGCTTCAAAACGTTTCTTAG
ACCTTCTTGCTGGTGTTGAAGACCCAGAGAAAAAACGTAAAATCATTGGTAATGAATTTGTCAGTGTATTTGATGACGAA
GCAAGCAAACTTAAAGGTGTTGACTTCTTAGCACAAGGTACTCTTTACACAGACGTTATTGAGTCTGGTACAGATACTGC
CCAAACAATCAAATCACACCACAACGTTGGTGGTCTCCCAGAAGATATGCAATTTGAATTGATTGAGCCACTCAACACAC
TGTTCAAAGATGAAGTTCGTGCGCTTGGTACAGCTCTTGGTATGCCAGATGAAATCGTTTGGCGCCAACCATTCCCAGGA
CCAGGACTTGCTATCCGTGTTATGGGTGAAATCACAGCTGAACGTCTTGAAACTGTTCGTGAATCTGACGCTATCCTTCG
TGAAGAAATTGCTAAAGCAGGTCTTGACCGCGACATCTGGCAATATTTCACTGTTAACACAGGTGTTCGTTCAGTTGGTG
TTATGGGTGATGGACGCACTTACGACTATACAATCGCAATTCGTGCTATCACATCAATCGACGGAATGACAGCAGACTTT
GCACGTATCCCATGGGATGTGCTTCAAAAAATCTCAGTCCGTATCGTAAATGAAGTTGACCACGTCAACCGCATCGTCTA
TGACATCACAAGTAAACCACCAGCAACAGTTGAGTGGGAATAA

Protein sequence :
MTDNSSLNNVQKIIVLDYGSQYNQLIARRIREFGVFSELRSHKITAEEVREINPIGIVLSGGPNSVYADNAFGIDEEIFE
LGIPILGICYGMQLLTDKLGGKVVPAGQTGNSEYGQSTLRLKANSKLFADTPEKQTVLMSHGDAVTEIPAGFHLVGDSAD
CPYAAIENTEKNIYGIQFHPEVRHSVYGNDILRNFAFKICGAKGDWSMDNFIELQISEIRKKVGNRKVLLGLSGGVDSSV
VGVLLQRAIGDQLTCIFVDHGLLRKGEGDQVMNMLGGKFGLNIIRVDASKRFLDLLAGVEDPEKKRKIIGNEFVSVFDDE
ASKLKGVDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTALGMPDEIVWRQPFPG
PGLAIRVMGEITAERLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
ARIPWDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-173 70
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-173 70
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-173 70
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-121 52