Gene Information

Name : Isova_0872 (Isova_0872)
Accession : YP_004541550.1
Strain : Isoptericola variabilis 225
Genome accession: NC_015588
Putative virulence/resistance : Unknown
Product : adenine-specific DNA-methyltransferase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : 2.1.1.72
Position : 947803 - 949503 bp
Length : 1701 bp
Strand : +
Note : KEGG: bcv:Bcav_3915 N-6 DNA methylase; PFAM: DNA methylase, adenine-specific

DNA sequence :
GTGCCACCGAGGAAGAAGGCAGCCGCGCCGACCGTCGCCACGGCGACGACGATGAAGGAGCTGAAGGACACGCTCTGGAA
GGCCGCGGACAAGCTGCGCGGCTCGATGGACGCCAGCCAGTACAAGGACGTGATCCTGGGGCTCGTGTTCCTCAAGTACG
TCTCGGACGCGTTCGAGGAGCGCCGTGCGGCCATCCTCGAGGAGTGCCTCGCCGACGGCCTCAGCGAGGACGACGCGGCA
CCGCTGCTGGAGGACGTCGACGAGTACCGCCGCGCGGGAGCCTTCTGGGTTCCCGAGCGCGCACGGTGGGGCTACCTGGC
GCAGCACGCCAAGGGCCGCTCCGCGACGCCAGACGAGCCGGAGGCGTCGATCGGGCAGCTCGTCGACGACGCCATGCTGC
TGCTGATGGGCTCGAACCCGACGCTCAAGGGCACGCTGCCGACGATCTTCAACCGCGACAGCGTCGACCAGCGCCGCCTC
GGAGAGCTCGTGGATCTGTTCTCGTCCGCCCGATTCACCGGGGTGATGGCGGACGGTACGAAGGTCTCCAAGGCACGCGA
CGTGCTCGGTGAGGTCTACGAGTACTTCCTCGGCAAGTTCGCCGCAGCGGAGGGTAAGCGTGGCGGCGAGTTCTACACGC
CTCCGGGCGTGGTCCGCGTGCTGGTCGAGGTGCTCGAGCCGTACCGCGGTCGTGTGTACGACCCGTGCTGTGGGTCGGGT
GGCATGTTCGTCCAGGCCGAGAAGTTCCTCGAGCGCCACGGCGCCGACCCGCAGGCGATCAGTGTGTTCGGGCAGGAGCT
CAACGAGCGCACGTGGCGCATGGCGAAGATGAACCTCGCCGTGCACGGGCTGACCGGGAATCTCGGGCCGCGGTGGGGCG
ACACGTTCGCTCGTGATCTGCACCCCGAGCTGCAGGCCGACTACGTCCTCGCGAACCCGCCGTTCAACATCAAGGACTGG
GCGCGCAACACCGACGACGCGCGGTGGAAGTTCGGCGTCCCGCCGGCGGGCAACGCCAACTACGCGTGGATCCAGCACAT
CTTGTCCAAGCTCGCGCCCGGCGGGTCCGCCGGTGTCGTCATGGCGAACGGGTCGATGTCGTCCAACTCCGGGGGAGAGG
GCGAGATCCGGGCCCAGCTCGTCGAGGCTGACCTCGTGAGCTGCATGGTCGCACTGCCGACGCAGCTCTTCCGCTCGACC
GGCATCCCCGTGTGCGTGTGGTTCTTCGCCAAGGACAAGGGCGCGCGGGCTGGAGAGGTGCTGTTCATCGACGCCCGGAA
CCTGGGCCACATGGTCGACCGGGCCGAGCGCGCGCTGTCCGACGACGACATCGCCAAGATCGCGGACACGTACCACGCCT
GGAAGCGCGGACCCTCACCAGAGTCCGAGCCTGTCGAAACCCTTCCGGTGGTTGAGCCCGTCGAAACTGAGCCTGTCGAA
ACCGAGCCGGTGGTTGAGCCTGTCGAAACCACTTACAGCGACATCCCCGGCTTCTGCTACTCCGCCACGCTGGCTGAGAT
CAAGGACGCCGGCTACGCGCTCACGCCGGGCCGGTACGTCGGCGCCGCTGAGGTGGAGGACGACGGCGAGCCCATCGAGC
AGAAGATCGAGCGTTTGACTGCGGAACTATTCGCGCAGTTCGACGAGTCCGCGCGCCTAGAGCAGGTGGTGCGCGAGCAG
CTGGGGCGGGTCCATGGCTGA

Protein sequence :
MPPRKKAAAPTVATATTMKELKDTLWKAADKLRGSMDASQYKDVILGLVFLKYVSDAFEERRAAILEECLADGLSEDDAA
PLLEDVDEYRRAGAFWVPERARWGYLAQHAKGRSATPDEPEASIGQLVDDAMLLLMGSNPTLKGTLPTIFNRDSVDQRRL
GELVDLFSSARFTGVMADGTKVSKARDVLGEVYEYFLGKFAAAEGKRGGEFYTPPGVVRVLVEVLEPYRGRVYDPCCGSG
GMFVQAEKFLERHGADPQAISVFGQELNERTWRMAKMNLAVHGLTGNLGPRWGDTFARDLHPELQADYVLANPPFNIKDW
ARNTDDARWKFGVPPAGNANYAWIQHILSKLAPGGSAGVVMANGSMSSNSGGEGEIRAQLVEADLVSCMVALPTQLFRST
GIPVCVWFFAKDKGARAGEVLFIDARNLGHMVDRAERALSDDDIAKIADTYHAWKRGPSPESEPVETLPVVEPVETEPVE
TEPVVEPVETTYSDIPGFCYSATLAEIKDAGYALTPGRYVGAAEVEDDGEPIEQKIERLTAELFAQFDESARLEQVVREQ
LGRVHG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 4e-128 50
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 6e-128 50
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 2e-129 50
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 5e-109 45