Gene Information

Name : Isova_2265 (Isova_2265)
Accession : YP_004542879.1
Strain : Isoptericola variabilis 225
Genome accession: NC_015588
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 2458725 - 2460815 bp
Length : 2091 bp
Strand : -
Note : PFAM: Amidohydrolase 1; Urease alpha-subunit, N-terminal; Urease, beta subunit; TIGRFAM: Urease, alpha subunit; Urease, beta subunit; HAMAP: Urease subunit alpha; KEGG: cfl:Cfla_0697 urease, alpha subunit

DNA sequence :
ATGGCCAGCCACGCCACCACCGGCCCGGGTGCGGTCCGCGTCGCCGAGGGCACCGTCGCGCTCAACGCCGACCGCGCCCC
GCACGAGCGCATCGAGCTCGTCGTGCTGAACACGGGCGACCGTCCCGTCCAGATCGGCTCCCACCTGCACCTGCCGGACG
CCAACCCGGCCCTGGAGCTCGATCGTGACGCCGCCCACGGGTTCCGCCTCGACGTGCCGGCCGGCACCTCCCAGCGCTTC
GAGCCCGGCGCCTCCCGCACCGTCACCGCCGTCACGCTGCGCGGCCAGCGCCGCGTGCCCGGCATCCGCCGCGCCAAGAC
CGACGGCGGGGCGCTCGGCGACGTCGCGGTCCCCGACGACGCCACCGCGGTCGGGCGGCCCGTCCCGGCCCTCGTCATCC
CGCGCGAGCGGTACGCCGCCCTCTACGGTCCGACCGTCGGCGATCAGCTGCGCCTGGGTGACACCGATCTGTGGATCGAG
GTGGAGGAAGACCGCACCGCCGGCGGCGACGAGGCGGTGTTCGGCGGTGGCAAGTCGATCCGTGAGTCGATGCTCCAGGG
CTCGACGACCCGCGCCGAGGGCGCGCCGGACACGGTCATCACCAACGTCGTCATCCTGGACTGGTGGGGCGTGGTCCGCG
CCGACGTCGGCATCCGCGACGGACGCATCGTCGCGCTCGGCAAGGCCGGGAACCCGGACGTCGCCGACGGCGTGCACCCC
GCGCTGCACATCGGCCCGTCCACGGACGTGATCAGCGGCGAGGGTCGGATCCTGACCGCCGGCGGGTTCGACGCGCACGT
CCACCTCATCTCCCCGTCCCAGCTCGTTGAGGCCCTCGCCACCGGGATCACCACCGTGGCCGGCGGCGGGACGGGACCCT
CGGAAGGGACGAAGGCCACCACCGTCACCCCGGGCGCATGGCACCTGCGCACCATCCACCGCAGCCTGGACCACGTGCCC
CTGAACGTCCTGCTGCTGGCCAAGGGCAACACCGTCAGCGGCGAGGCCCTCGCGGAGCAGGCACTGGCAGGCGCCGGCGG
GTACAAGGTGCACGAGGACTGGGGCTCCACCCCGGCCGCGCTCGACGCCGCCCTCGGCGCGGCTCGGGACTGGGGGCTGC
AGGTCGCCCTGCACTCCGACTCCCTGAACGAGGCCGGCTTCCTGGAGTCGACGGTCTCGGCGATCGGGGGCCGGTCCATC
CACGCGTTCCACACCGAGGGCGCCGGCGGCGGTCACGCCCCCGACATCATGCGGCTGGCCGGCGAACCCTACGTGCTGCC
CGGCTCCACCAACCCCACGCTGCCGCACACCCGCAACACCGTGGATGAGCACCTCGACATGCTCATGGTCTGCCACCACC
TGAATCCCCGCGTGCCCGAGGACCTCGCGTTCGCCGAGTCCCGGATCCGCGCAACCACGATCGCGGCGGAGGACGTGCTG
CACGACATGGGCGCGATCTCCATGACGTCCTCGGACGCCCAGGCGATGGGCCGCATCGGCGAGGTCATCACCCGCACCTG
GCAGGTCGCCCACGTCATGAAGCACCGCCGGGGCCCCTTGTCCAGCGGGCTGCCGGCCGACAACGAGCGCGCTCGCCGGT
ACGTCGCCAAGTACACGATCAACCCAGCGGTCGCCCACGGCGTCGACTCCGAGATCGGCTCGGTCGAGGTCGGCAAGCTG
GCCGACCTCGTGCTGTGGGACCCGCGCTTCTTCGGTGTGCGCCCCGCGGTCGTGCTCAAGGGCGGCGCCCTGGTGTGGGG
CGCGCTCGGCGACCCCAACGCGTCGATCCCGTCGCCCCAGCCCGTGCTGCAGCGCCCGGCGCTCGCCGACGCCGTCGGCG
CGGACGTGTCCGTGTCCTTCGTGGCACCGCGGGCGCTGGAGGAGGGGCTGGCCGAGGAGCTGGGGCTGCGCCGCCGCCTC
GTCGGCGTCGCCGACACCCGCGCCGTCGGCAAGGCGCACATGAAGAACAACGACGTGTGCCCCCACATCGACATCGACCC
GGAGACCTTCCGGATCGACGTCGACGGCGAGCGCGTCGAGCCCGCCCCGGTCGACGAGGTGCCCCTGGGGCAGCTCTACT
CGATGTTCTGA

Protein sequence :
MASHATTGPGAVRVAEGTVALNADRAPHERIELVVLNTGDRPVQIGSHLHLPDANPALELDRDAAHGFRLDVPAGTSQRF
EPGASRTVTAVTLRGQRRVPGIRRAKTDGGALGDVAVPDDATAVGRPVPALVIPRERYAALYGPTVGDQLRLGDTDLWIE
VEEDRTAGGDEAVFGGGKSIRESMLQGSTTRAEGAPDTVITNVVILDWWGVVRADVGIRDGRIVALGKAGNPDVADGVHP
ALHIGPSTDVISGEGRILTAGGFDAHVHLISPSQLVEALATGITTVAGGGTGPSEGTKATTVTPGAWHLRTIHRSLDHVP
LNVLLLAKGNTVSGEALAEQALAGAGGYKVHEDWGSTPAALDAALGAARDWGLQVALHSDSLNEAGFLESTVSAIGGRSI
HAFHTEGAGGGHAPDIMRLAGEPYVLPGSTNPTLPHTRNTVDEHLDMLMVCHHLNPRVPEDLAFAESRIRATTIAAEDVL
HDMGAISMTSSDAQAMGRIGEVITRTWQVAHVMKHRRGPLSSGLPADNERARRYVAKYTINPAVAHGVDSEIGSVEVGKL
ADLVLWDPRFFGVRPAVVLKGGALVWGALGDPNASIPSPQPVLQRPALADAVGADVSVSFVAPRALEEGLAEELGLRRRL
VGVADTRAVGKAHMKNNDVCPHIDIDPETFRIDVDGERVEPAPVDEVPLGQLYSMF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 8e-136 56
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 8e-136 56
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-127 54
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-127 54
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-127 54
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-127 54

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Isova_2265 YP_004542879.1 urease subunit alpha VFG0270 Protein 2e-123 53