Gene Information

Name : Thicy_0376 (Thicy_0376)
Accession : YP_004536630.1
Strain : Thioalkalimicrobium cyclicum ALM1
Genome accession: NC_015581
Putative virulence/resistance : Virulence
Product : ATP-dependent chaperone ClpB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 516808 - 519369 bp
Length : 2562 bp
Strand : +
Note : TIGRFAM: Chaperonin ClpB; PFAM: ATPase associated with various cellular activities, AAA-2; ATPase, AAA-type, core; Clp, N-terminal; Clp ATPase, C-terminal; KEGG: tcx:Tcr_0414 AAA ATPase; SMART: ATPase, AAA+ type, core

DNA sequence :
ATGGATAAATTTACTAGCCAGTTTCAATCGGCTCTAGCGCAAGCGCAATCTCTGGCCAATAGCCAAGATAATCAATTTAT
TGAACCTGTACATATTTTATCCAGTTTATTGCCTGACCAGGGTCATTTATTGCGCCTAGCCGGTGTCGATGTCAATGGGC
TGAATCAAGCCGTGCAGGCCAAACTGAAAACCCTGCCGCAAGTGAGTGGGGCAGGCGGCGATGTGCAAATCTCGCGTCAA
ACCGGCGCGATTTTGAATTTAATGGAAAAACAGGCGCAGAAAAATGGCGATGCCTATATTTCGAGCGAGCTGTTTTTCCA
AGCCGCTCTGGAATCCAAAGATCAGGTGGCCGATTTATTAAAGCAAGCGGGGACGACTGAGAGCAGACTCGCTCAGGCGA
TTCAACAAGTACGAGGAGGGGAAAGCGTGCAAGACCAAAATGCTGAGTCCACGCGTCAAGCGTTGAAAAAATACACCATA
GATTTAACCTCGCGCGCCGAGTCGGGCAAACTCGATCCGGTGATTGGTCGAGACGACGAAATCCGCCGTGCGATACAGGT
TTTGCAACGCCGCACCAAAAACAATCCGGTATTAATCGGTGAGCCGGGTGTCGGTAAAACCGCGATTGTGGAAGGCTTAG
CGCAGCGTATTATCAATGGCGAAGTGCCGGAAGGTTTGCGTAACAAGCGGGTGTTGTCGCTGGACTTGGGCGCGTTGTTG
GCCGGTGCGAAATATCGCGGCGAGTTTGAAGAACGCCTCAAAGCGGTGCTAAAAGACCTGTCGAAAAACGAAGGCCAGGT
GATTTTGTTTATTGATGAAATTCATACCATGGTCGGCGCGGGTAAAGCCGAAGGCGCAATGGACGCAGGTAATATGCTGA
AACCGACCCTGGCGCGCGGTGAGTTGCATTGCATCGGCGCGACCACGCTGAATGAATACCGTGACAATATCGAAAAAGAC
GCCGCGTTGGAGCGCCGTTTCCAAAAAGTATTGGTCGATGAACCGACTGAAGAAGATACGATTGCGATTTTGCGCGGCTT
AAAAGAACGTTACGAAGTGCATCACGGCGTGGCGATTACCGATCCGGCAATTGTGGCGGCGGCGCGTTTGTCGCAACGTT
ATATCACTGACCGCCAACTGCCGGATAAAGCAATTGATTTGATCGATGAAGCCGCCTCGCGTATTCGGATGGAGATTGAC
TCTAAACCGGAAGAAATGGACAAGCTTGATCGCCGTTTAATCCAGCTCAAAATGGAGCAGGTGGCGCTGAAAAAAGAGAA
AGACGATGCCTCGAAAAAAAGACTGGAAATCTTAAAAGACCAAATCAAAGAACTAGAAAAACAATATTCCGATTTTGAAG
AAGTCTGGAAAAAAGACAAGGCCGCTTTGCAGGGCGCACAGCAATACAAAGAAGCGCTCGACAAAGCACGTACCGAAATG
GAAGCCGCACGCCGTGAAGGCAATTTAGCCAGGATGTCAGAGTTGCAATATGGCGTGATTCCCGATTTAGAAGCCAAAAT
CAAAGCGGCTGAAGCGTCGGAAGCGGAAGGCGACGACCACATGCATCTGTTGCGTAATAAAGTCACCGAAGATGAAATTG
CTGAAGTCGTGTCGCGCTGGACTGGTATCCCGGTGTCGCGCATGATGGAAGGCGAGCGCGAAAAACTTCTGCGTATGGAA
GAAAGCCTCAGCGCCAAAGTGGTTGGTCAAGACGAAGCGGTGAAAGCGGTGTCGGATGCGATTCGTCGTTCGCGCGCCGG
ATTATCCGACCCGAACAAACCGAATGGTTCGTTCCTATTCCTTGGCCCAACAGGGGTGGGGAAAACCGAGCTGACCAAAT
CCTTGGCGGATTTCTTGTTCGATAGCCAAGATGCGATTGTGCGGTTGGATATGTCGGAGTTTATGGAAAAACACTCGGTC
GCACGTTTAATCGGTGCGCCGCCCGGTTATGTCGGTTACGAGCAAGGTGGTTATCTAACCGAAGCCGTGCGCCGCAAGCC
TTACTCGGTGATTCTGCTGGATGAGGTTGAAAAAGCGCACCCAGATGTGTTTAATATTCTGCTGCAAGTGCTGGACGACG
GGCGTTTAACCGACGGTCAAGGTCGCACGATAGATTTCCGTAACACGGTCATTGTGATGACCTCCAACCTCGGTTCGCAG
ATTATTCAAGAACTGGCGGGCGAAGCGAATTACGATGCCATGAAGTCTGCGGTAATGGATGTGGTCGGTGGCCATTTTCG
CCCTGAGTTTGTCAACCGTATTGACGACATTGTGGTGTTCCATCCGCTTGGTAAAGCGCAAATTCGTGCGATTACCGATA
TTCAGCTACAGCGTCTGCGTGATCGTTTGGTGGATTTGGATATTAAACTCGATGTGTCGATTCCGGCGCTGGATGTGATG
GGCGAAGCCGGGTTCGATCCAGTGTATGGCGCGCGTCCGCTTAAACGGGTGATTCAGCAACGCTTAGAAAACCCGCTAGC
GCAACGCATCCTAAAAGGCGAGTTCCTTGCGGGTTCAACTATTCACGTTGAACTGGAAGACGGCGAGCTTAACTTCCACT
AA

Protein sequence :
MDKFTSQFQSALAQAQSLANSQDNQFIEPVHILSSLLPDQGHLLRLAGVDVNGLNQAVQAKLKTLPQVSGAGGDVQISRQ
TGAILNLMEKQAQKNGDAYISSELFFQAALESKDQVADLLKQAGTTESRLAQAIQQVRGGESVQDQNAESTRQALKKYTI
DLTSRAESGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLRNKRVLSLDLGALL
AGAKYRGEFEERLKAVLKDLSKNEGQVILFIDEIHTMVGAGKAEGAMDAGNMLKPTLARGELHCIGATTLNEYRDNIEKD
AALERRFQKVLVDEPTEEDTIAILRGLKERYEVHHGVAITDPAIVAAARLSQRYITDRQLPDKAIDLIDEAASRIRMEID
SKPEEMDKLDRRLIQLKMEQVALKKEKDDASKKRLEILKDQIKELEKQYSDFEEVWKKDKAALQGAQQYKEALDKARTEM
EAARREGNLARMSELQYGVIPDLEAKIKAAEASEAEGDDHMHLLRNKVTEDEIAEVVSRWTGIPVSRMMEGEREKLLRME
ESLSAKVVGQDEAVKAVSDAIRRSRAGLSDPNKPNGSFLFLGPTGVGKTELTKSLADFLFDSQDAIVRLDMSEFMEKHSV
ARLIGAPPGYVGYEQGGYLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTIDFRNTVIVMTSNLGSQ
IIQELAGEANYDAMKSAVMDVVGGHFRPEFVNRIDDIVVFHPLGKAQIRAITDIQLQRLRDRLVDLDIKLDVSIPALDVM
GEAGFDPVYGARPLKRVIQQRLENPLAQRILKGEFLAGSTIHVELEDGELNFH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 3e-161 46
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 1e-104 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Thicy_0376 YP_004536630.1 ATP-dependent chaperone ClpB VFG2076 Protein 7e-116 42