Gene Information

Name : pyk (TREPR_0649)
Accession : YP_004532256.1
Strain : Treponema primitia ZAS-2
Genome accession: NC_015578
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 3671619 - 3673412 bp
Length : 1794 bp
Strand : -
Note : identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064

DNA sequence :
ATGAAAATAATCCGAAATACCCACATTATTTGTACCATGGGACCTACCACAGAATCGTTGGAAATGGTCCGTTCCCTAAT
CCGTAAGGGGATGAACCTGGCCCGGTTTAATTTTTCCCATGGGGAACATGGGTATCATGGGGCGATGATAGCCCGGGTCC
GGGAGGCCGCCGCCGCCGAGGGGGTTCCCATTGCCCTGATCCTGGATACCAAGGGCCCGGAAATTCGCACCGGCAAGATC
AGGGACAACGGTATTGTCGAGTTGGTTTCCGGTGAAAAATTGGATGTGATCGCCGAAGCCGATGCGACGGCCCTCTATGG
TGAGGAGGGCGCTTTTACCAGTAAAGGGCGGATCACCGTGAGTTACCAATCCCTGGCAGATGATATACGGCCAGGCGCCC
GGATCCTTATTGCGGATGGGATTTTTTCCCTGGATGTTCTTTCCCTTGAGGGACGGGTCATGCGCTGCCGGGTTGAAACC
GGGGGAGAATTGGGGGGCAGGAAAAATGTGAACATCCTGGGGGTGCACACCCGGCTTCCGGCTATGTCTGAAAAGGATAT
GGATGATCTCCGGTTTGGCCATGAACAGGAGATGGATTATGTGGCGGCTTCCTTTATCCGCAAGGCTTCGGATGTTACGG
CCATACAGAAATACCTGGTCTCCATCGGTTCGGATATGCAGGTTATTGCTAAAATTGAAGACGATGAGGGGCTGCAAAAT
ATCGAAGAAATTATCCGGGTTTCTGCCGGGATAATGGTAGCCCGGGGAGACCTAGGGGTGCAGATACCCCCTGAACGGGT
GCCCCTGGAACAGAAACGGATCATCAGCCTCTGCAATAAAGAGGGAAAGCCGGTGATCACCGCCACCCAGATGTTGGACT
CCATGACCCATAACTCCCGGCCTACCCGGGCTGAAGCGGGGGATGTGGCCAACGCTATCCTGGACGGCACGGACTGCGTG
ATGCTTTCCGGAGAAACCGCCAACGGCGCCTGGCCTGAAGCGGCGGTAGAAGTGATGGACCGCATCGCCCTGGCGGCGGA
GTCTTCGGAGGAATACCGGAACAACATGTGGGAACGCCGCAGAACCTTCCACGAACAGGATCTGGGCCAGGTCATCGCCG
GGGCTGCGGTTAACACCGCCGACGCTATCGGCGCTTCCTGTATCATCATGCCCACCCTGAGCGGCCTTACCGCCCAGCTG
GTGAGCAAGCGCCGTCCCCAACGCTGTATTGTGGCGGCTACCCCCAGTGAAAAGGTGCGCCGGCGGCTCCTCCTCTATTG
GGGGGTGGTCCCAGTGGAGGTACAGAGGGAAGAGGATTCGGAGGCCATGATCCAGGGGGCTATCGGTGCCGCGATCAAGG
AAGGCTTTGCCGCATCTGCGGATAAGGTGGTGGTAGTGGCGGGGCTGCCGGTCAATTCGCCCATAACCACCAACAGCATC
AGGGTCCATGTAATCGGTACCGTACTGGGCCGGGGTGCCCGGGGCTTCGGCGGCCGCTGTACCGGCCGGGTGATTAAGGC
GGAAAACCTTGTAGAGGCGGCCCGGTGGCTTCGGAGCAAGGGGGGGGAAATACTCCTGACCCATACCCTGGATGAATCCT
TTACCCCCATTATCCGCATCGTGGACGGCGTTATCCTTGAGGGGACTTCGGAATTGTCCCGGGAGCATATCAAGAATATC
AACCCCAATGTGGTCTATGTGGCCCAAGTACCGGGGGCAATGAATTTATTTGAGGAAAATTCCACGGTAACCCTGGATGG
GGCGGAGAAACTGATCTACGAAGGGACCCTGTAG

Protein sequence :
MKIIRNTHIICTMGPTTESLEMVRSLIRKGMNLARFNFSHGEHGYHGAMIARVREAAAAEGVPIALILDTKGPEIRTGKI
RDNGIVELVSGEKLDVIAEADATALYGEEGAFTSKGRITVSYQSLADDIRPGARILIADGIFSLDVLSLEGRVMRCRVET
GGELGGRKNVNILGVHTRLPAMSEKDMDDLRFGHEQEMDYVAASFIRKASDVTAIQKYLVSIGSDMQVIAKIEDDEGLQN
IEEIIRVSAGIMVARGDLGVQIPPERVPLEQKRIISLCNKEGKPVITATQMLDSMTHNSRPTRAEAGDVANAILDGTDCV
MLSGETANGAWPEAAVEVMDRIALAAESSEEYRNNMWERRRTFHEQDLGQVIAGAAVNTADAIGASCIIMPTLSGLTAQL
VSKRRPQRCIVAATPSEKVRRRLLLYWGVVPVEVQREEDSEAMIQGAIGAAIKEGFAASADKVVVVAGLPVNSPITTNSI
RVHVIGTVLGRGARGFGGRCTGRVIKAENLVEAARWLRSKGGEILLTHTLDESFTPIIRIVDGVILEGTSELSREHIKNI
NPNVVYVAQVPGAMNLFEENSTVTLDGAEKLIYEGTL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 2e-74 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 1e-73 42
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 3e-74 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 2e-74 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_004532256.1 pyruvate kinase VFG0479 Protein 7e-75 42