Gene Information

Name : TREPR_0836 (TREPR_0836)
Accession : YP_004532089.1
Strain : Treponema primitia ZAS-2
Genome accession: NC_015578
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 3486570 - 3487823 bp
Length : 1254 bp
Strand : +
Note : identified by match to protein family HMM PF01053

DNA sequence :
ATGGGAGGATTTTACACCGCATCGGGAAGGCCCGGCAAGCTTATCTTCCTGTTGTCTTTTTTACCCCCTTTCCCTATACT
TTCGATACTTTACACAAGACTTAACGGGGGTATTATGAACAAGGGTTCCTTATTGATTCACAATGGCCATGAACTGGATC
CGGCTACCGGGGCGTTGGGAGTAACCGTATACCAGACATCGACCTTTTACCGGAAAGACATGACCGGCAAACAAACCCAG
GAATTCGACTATTCCCGGGGGGGCAACCCTACCCGGAAGGCCCTGGAAGAGACCATCGCAATCCTGGAGGGCGGGGCAAA
GGGCTATGCCTTTGGAAGCGGGATGGCGGCTATTTCTTCGGTAATAGGGCTCCTGGCCACGGGGGATCACATCATTGCAC
CCCAGGATATTTATGGCGGAAGCTGGGTCATTATGGATACCTTCTATAAAAGGTGGGGCCTTGAACTGACCCTGGTGGAT
ACCGCGGATCCGGAAAATATCAGGAAGGCCATCAAGCCCAACACTAAGGCGCTGTACCTGGAATCCCCTTCGAATCCCCT
GCTCAAGATTACGGACCTCAAGGCCTGTCTGGGGATTGCCCGGGAAGCGGGGCTCCTTTCTATTGTAGATAATACCTTCA
TGACCCCCTACCTTCAGCGGCCCATTGAATTGGGGGCGGATGTGGTGGTCCATTCGGCAACTAAGTTCCTGGGCGGCCAC
AGCGACGTAATTTCCGGGCTGGCGGTAACCAAAACGGCGGAGCTGGGGCAAAGGCTGTATGCGGTACAGAACAGTTTCGG
CGCCGTGCCCGGCCCCTGGGATACCTGGCTGGTCATCCGGGGGATCAAGACCCTCAAGGTGCGGCTGGAAACCCAGCAAG
CCACGGCGAAACGTGTGGCGGAATGGCTCCTGACCCATAAAAACGTGACCAATGTCTATTATCCAGGCCTGGAGAACCAT
CCAGGCGCCGAGGTCCACCGGTCCCAGTCCTCAGGTCCCGGGGCCATGCTGTCTTTCAAGACCAAAACCACCGAACAGGC
CCTCAATTTCTACAGCCGGATCAAACTGGCCGCCGCTGCCCCCAGCCTGGGTGGGGTGGAAAGCATCGCTTCCTATCCGG
TCAAGATGAGCCACGTAGCCATGGCCCCGGCGGAGCGGGAGCGGCTGGGCATCACCGATACCCTGGTCCGCATTGCCATA
GGCCTGGAGGATGCGGATGACCTGATCGCCGATTTCGACCAGGCCCTGAGCTAA

Protein sequence :
MGGFYTASGRPGKLIFLLSFLPPFPILSILYTRLNGGIMNKGSLLIHNGHELDPATGALGVTVYQTSTFYRKDMTGKQTQ
EFDYSRGGNPTRKALEETIAILEGGAKGYAFGSGMAAISSVIGLLATGDHIIAPQDIYGGSWVIMDTFYKRWGLELTLVD
TADPENIRKAIKPNTKALYLESPSNPLLKITDLKACLGIAREAGLLSIVDNTFMTPYLQRPIELGADVVVHSATKFLGGH
SDVISGLAVTKTAELGQRLYAVQNSFGAVPGPWDTWLVIRGIKTLKVRLETQQATAKRVAEWLLTHKNVTNVYYPGLENH
PGAEVHRSQSSGPGAMLSFKTKTTEQALNFYSRIKLAAAAPSLGGVESIASYPVKMSHVAMAPAERERLGITDTLVRIAI
GLEDADDLIADFDQALS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-83 47
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-84 47
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-71 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TREPR_0836 YP_004532089.1 cystathionine gamma-synthase BAC0207 Protein 2e-59 42