Gene Information

Name : TREPR_1834 (TREPR_1834)
Accession : YP_004531175.1
Strain : Treponema primitia ZAS-2
Genome accession: NC_015578
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2413474 - 2416089 bp
Length : 2616 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
TTGTCAAAAGGTTTAACCCAGCGGGCCCATCGTATATTGACCATCGACGCTCAGGAAGAGGCGCGTCACTTTAATTCGGA
TCAGCTCCTGCCGGAACATGTGGTAATTGCCCTGCTCAAAGAAGGGGCGGGTATAGGCTGCAAAGCCCTGATGTTCCTCA
GAATCGATTTACAGGAATTCCGGCATACCCTAGAAAATGAAATTACCCGGATGAGCGGGCTTCTGGTGTACGGGGACGTT
CCTCCTTCCAAACGAACCAGGGCCTTGCTGGAAAATGCCGCCGAAGAAGCCCGGACCATGGGCAATGATTATATTGGCAC
GGAACACATCCTCTTTGCCGCCATGCGTGAACAGGATTCACCGGTGCAGCTGTACCTGAACCAGCGGGCGGTGGATACAG
ATATGCTGCGGGTGGTGGTACAGACCACCTTTAGCCACGGCAGCGGACCGGAGGATGATTTTCTCCCCCCGGGCAAGATG
TCCGGGGCGCCTGAAGGGTACCAGTCCCCCTTCCTCCACAGCCGGGGCTCCGGGGGCTTTCCGCCGAAACCCGGTGAGGA
AGCCAGGCGTTCCCGGCCGGACCGGGTGAAACCGGTAAACTACCCTCCCCTCAGCGCCACCCCTACCCTGGATGAATACT
CCCGGGACCTGACCGCTTTGGCAAAACTGGGCAAACTGGATCCGGTGATCGGTAGGCGGAAGGAAATCGACCGGTCGGTG
CGTATCCTGGCCCGGCGGACCAAAAACAACCCGGTCCTGGTGGGTGAACCCGGGGTGGGAAAAACCGCCATCGTGGAAGG
CCTGGCCCAGCTCTTTTCCGGGGAGGATATCCCGGAAGCTCTGGCGGGAAAACGGATCCTCTCCCTGGACCTGGGCTCCG
TGGTTGCGGGAACCAAGTACCGGGGGGAATTTGAGGAACGGCTCAAAAAAATCATGAAGGAAATCGCTGCCGCCCGGAAT
GTGATCCTCTTTATTGACGAGATCCATACGATTATCGGGGCCGGGGGCGCCGAGGGAACCATTGACGCCTCGAATATGCT
CAAGCCCGCCCTTTCCCGGGGGGATATCCAGTGCATAGGCGCCACCACATTGGGGGAATACCGGAAGCACTTTGAAAAAG
ATGCGGCCCTGGAACGGCGTTTCCAGGCGGTGCAGGTGAATGAACCGGACACCGATGAAACTCTAAAGATACTCAAGGGC
ATTCAGAAAAAATACGAGGACCATCACCGGGTGACCTACACCCCCGAATCGGTGTCCGCCGCAGTGCGCCTGGCCCAACG
CTACATCATAGGCCGGTTTATGCCCGATAAGGCAATCGACATCATGGACGAGGCTGGGGCCATGCGGAAACTGGAAGCGG
GAAGCCATCCCCCGGAAGTTTCGGAAATCGAAACGGAAATACAGCAGCTTACCAACGAAAAAAGCGCCCTGGTTTCGGTC
CAGGATTATGAACGGGCCGCAGGAATCCGGGACCGGGTACGGAGCCTCAGGCTGCGCCTGGAGTCCCTCAGGGATGCCTG
GGAGCGGTCCTCCCGGGAAGAGCGGATGGTGGTGGACGAAGGGGATATGAGGCGGGTAGTTGCTGAAACCACCGGGATAC
CCCTGACCAGGATGGAAGAGCAGGAGTCCAGGCGGCTCCTGCGTATCGAGGAGGAGCTTCACAAGGAAGTGGTGGGCCAG
GACGAAGCGGTAAAGCGCATCGCCTCATCCATACGCCGTTCCCGGGCGGGGATTTCCTCACCCAAGCGGCCCATGGGATC
CTTCATCTTCCTGGGCCCCACGGGGGTGGGCAAAACCCTCCTGGCAAAACGGCTTTCCGAATACCTCTTCGGCAACGAGG
ATTCCCTGGTCCGCATCGATATGTCGGATTATATGGAAAAACACAATGCCTCCCGGCTGGTGGGGGCGCCCCCGGGCTAT
GTGGGCTACGAGGAAGGGGGCGCCCTGACCGAGCGCATACGCCGCAACCCCTACCGGGTGGTACTCTTTGACGAAATTGA
AAAGGCCCATCACGATGTGTTCAACCTGCTTTTGCAGGTGCTGGAAGAAGGGGAACTCAAGGACCACCTGGGGCATACGG
TAAATTTCCGGAACACCGTGATCATCATGACCAGCAATGCCGGGGTGCGGGAGATTTCCCGGGATTCCCAGCTGGGCTTT
GCCTCGGAGACCGGGATCATGAGCATTGAGGAGATCCAGAGCGCCGCCCTGGCTGAATTGCGCCGGCTTTTCAACCCGGA
ATTTATCAACCGGGTGGATGATGTGGTGGTCTTTCACTCCCTGACAGAGGAACAGGTGGCGGCCATCCTGGACTTGCAGG
TAGGGGAACTTTCCCAGCGGCTTGGGGAACAGGGCTACGGAATAGAAGTGCTGCCTGAGGCAAAAAAAATTCTGATTGAA
CAGGGCTGGGACCCCAAATACGGGGGCCGTCCCATGCGCCGGGCCATCCAGAAAGAGCTGGAGGACCCCTTGTCACTATT
GCTGTTGGAAGGGAACTACCCCTTCGGCTCACTGTTTGTAGCGGATGCTCAGGATGGCAAGATAAGCCTCAGGCCCGCAG
CAAAAGCCGGCGGCGGGCAGATGGTAACAGAGGATGTGCTGCCTGTGACCAGGTGA

Protein sequence :
MSKGLTQRAHRILTIDAQEEARHFNSDQLLPEHVVIALLKEGAGIGCKALMFLRIDLQEFRHTLENEITRMSGLLVYGDV
PPSKRTRALLENAAEEARTMGNDYIGTEHILFAAMREQDSPVQLYLNQRAVDTDMLRVVVQTTFSHGSGPEDDFLPPGKM
SGAPEGYQSPFLHSRGSGGFPPKPGEEARRSRPDRVKPVNYPPLSATPTLDEYSRDLTALAKLGKLDPVIGRRKEIDRSV
RILARRTKNNPVLVGEPGVGKTAIVEGLAQLFSGEDIPEALAGKRILSLDLGSVVAGTKYRGEFEERLKKIMKEIAAARN
VILFIDEIHTIIGAGGAEGTIDASNMLKPALSRGDIQCIGATTLGEYRKHFEKDAALERRFQAVQVNEPDTDETLKILKG
IQKKYEDHHRVTYTPESVSAAVRLAQRYIIGRFMPDKAIDIMDEAGAMRKLEAGSHPPEVSEIETEIQQLTNEKSALVSV
QDYERAAGIRDRVRSLRLRLESLRDAWERSSREERMVVDEGDMRRVVAETTGIPLTRMEEQESRRLLRIEEELHKEVVGQ
DEAVKRIASSIRRSRAGISSPKRPMGSFIFLGPTGVGKTLLAKRLSEYLFGNEDSLVRIDMSDYMEKHNASRLVGAPPGY
VGYEEGGALTERIRRNPYRVVLFDEIEKAHHDVFNLLLQVLEEGELKDHLGHTVNFRNTVIIMTSNAGVREISRDSQLGF
ASETGIMSIEEIQSAALAELRRLFNPEFINRVDDVVVFHSLTEEQVAAILDLQVGELSQRLGEQGYGIEVLPEAKKILIE
QGWDPKYGGRPMRRAIQKELEDPLSLLLLEGNYPFGSLFVADAQDGKISLRPAAKAGGGQMVTEDVLPVTR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 9e-145 53

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TREPR_1834 YP_004531175.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 8e-159 56
TREPR_1834 YP_004531175.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 1e-132 46