Gene Information

Name : clpA (TREAZ_0240)
Accession : YP_004527586.1
Strain : Treponema azotonutricium ZAS-9
Genome accession: NC_015577
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease ATP-binding subunit ClpA
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2237694 - 2240084 bp
Length : 2391 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR02639

DNA sequence :
ATGAAAATTTCGGATCATGTGCAGGCCATTATCAATGCGGCCTATAACGAAGCCAAGGCGAGGAACCACGAGTACCTTAC
CCCGGAGCATATACTTTACGCGGCCCTGAATTTCGACGAAGTCCAGGGCATATTGACTGCCTGCGGCGCAGACTTGATGA
TGCTCCGAAACGGCATGGAGAGCTTTTTTGAACAGAAAATTCCTGTTGTGGGAGGCGGAGACCCCATCCAGACCGCCAAT
TTTCAGAGTGTCATCGAGAGGGCGGTACTTTCCTATCAATCTGCCCAAAAGGATATGCTTGAGGTATCCGACATACTCGT
ATCCCTCTACGACGAGGACAGAAACTATTGCGCCTATTATCTCCGCCAGGCGGGGGTGGATCGTTTCGACCTGCTTAACA
TCCTCTCCCATGGCTTCGAATCCGGGGAGCGGGGGCCGGGACTTCGGGGCTTTACCAAGTCCGGGGCTTCTCCCAGGAAC
GAGGAAGATCCCAACAGGGACAACCTCCTGGACGACGAAATACCGGAAGCGGGCCCCAAATCCAAGGCTGCCAAGAAAAG
CGCCCTTGAGAGATTCGCCACAGAGCTTACTGCCCTGGCCAGGGAAAACCGGCTTGAACCGGTCATTGGCAGGGAATTGG
AACTGGACCGCACGGTGCAGGTGCTTTGCAGGCGGCTCAAGAACAATCCTGTCCATGTAGGCGATTCGGGTGTGGGCAAA
ACCGCCATCACCGAGGGGCTGGCCCAGCGCATAGTGGCGGGCAAAGTCCCCCCTACCCTGAAGGATTTTACCATCTATTC
CCTGGACATGGGCGCACTTGTGGCAGGCACTAAGTACCGGGGCGACTTTGAAGAGCGGATCAAGAGGGTTGTGGAAGAAA
TACTCAAAAAAGAAAAAGCCATACTTTTCATAGACGAGATCCATACCCTGGTGGGGGCGGGATCGGTTTCGGGCAGTGCG
CTGGACGCTTCCAACCTGCTTAAGCCTGCCCTAAGCTCCGGGAAGATACGCTGCATAGGTTCCACCACTCACGAGGAATA
CAGCAAATTCTTCGACAAGGACAGGGCGCTTTCGCGGCGTTTCCAGAAAATCGACATCAATGAACCAAGCGAAGTTGACG
CCATCAAGATCCTGCAGGGGCTTAAATCAAAATACGAGGATTACCACAAGGTCCACTATACCGATGAAGCCGTGGAAGGG
GCGGTGCGCCTCTCTGCCCAATACATCACCGAACGCCGCCTGCCGGACAAGGCTATAGATGTCATCGACGAGGCCGGCGC
CTTTGCCCGTATCGAGGCGTATAAAAAGGAATCCGCCGGCCAGAATGCCGAAGAGCCTGCGGTAACGGAACATTCCATTC
AGGAAGCTTCCACATCAGTAGGCACTATAGACATAGGGCTCCCCCTTATCGAGACAGTGATTTCCAAAATCGCCCGCATC
CCGGAACGCTCGGTTGGGGGCAGGGAGAAGGATAAACTCAGGGAGCTGGAAGAAAAGCTCCGCACCAGGATCTTTGGGCA
GGACGAGGCTGTTACCGCGGTGGTCAAGGCTGTAAAGCGGTCGAGGGCCGGCTTTAGGGATGCCAATAAACCGGTGGCCA
ACTTCCTCTTTGTGGGGCCTACGGGGGTCGGCAAAACAGAGCTTGCCCGGAGCCTTGCGGATATCATGGGCGTATCCATG
CATCGCTTCGATATGAGCGAGTACCAGGAGAAGCACACGGTTTCCCGCCTCATAGGATCGCCCCCCGGTTATGTGGGTTA
TGAAGAAGGCGGCCTCCTTACCGATGCCATACGCAAGCAGCCCCACAGTGTGGTGCTCCTGGACGAGATTGAAAAAGCCC
ACCCGGATATTTACAACATACTCCTCCAGATCATGGATTATGCTACCCTCACGGACAACAACGGCAGGAAGGCCGACTTC
CGCAATGTGGTGCTTATCATGACCAGCAATGCAGGCGCCAGGGACATCGGCAAAAACCTCATCGGCTTTGGCGAGCGCGT
CATGGACGAGAGCGCCGTGGACGGAGCTGTGGAAAAAATATTCACCCCGGAATTCCGCAACCGCCTTGACGCCGTGGTGC
GCTTCGGGCATCTCTCAAAAGAAATCATGGCGTCCATTGTGACCAAGGAGCTTGAAAACTTTAAGGGACAGCTGGCCGAA
AAGAAAGTGCATCTTCACGTGAGCGAAGCCTGCATTGCCCAGCTGGCTGAAGAAGGCTATTCCCGGGAATTCGGCGCCCG
CAATGTGGGCAGGGTGGTGGAAGAAAAGATCAAAGCCTTTTTTGTGGACGAGGTCCTCTTTGGCCGCTTGAGCGAGGGCG
GCGCAGCGCGAGCCGATTATGCCGACGGTGAATTCAAGATCGAAATACTGGAAAACGAGCCAGTCGCCTAA

Protein sequence :
MKISDHVQAIINAAYNEAKARNHEYLTPEHILYAALNFDEVQGILTACGADLMMLRNGMESFFEQKIPVVGGGDPIQTAN
FQSVIERAVLSYQSAQKDMLEVSDILVSLYDEDRNYCAYYLRQAGVDRFDLLNILSHGFESGERGPGLRGFTKSGASPRN
EEDPNRDNLLDDEIPEAGPKSKAAKKSALERFATELTALARENRLEPVIGRELELDRTVQVLCRRLKNNPVHVGDSGVGK
TAITEGLAQRIVAGKVPPTLKDFTIYSLDMGALVAGTKYRGDFEERIKRVVEEILKKEKAILFIDEIHTLVGAGSVSGSA
LDASNLLKPALSSGKIRCIGSTTHEEYSKFFDKDRALSRRFQKIDINEPSEVDAIKILQGLKSKYEDYHKVHYTDEAVEG
AVRLSAQYITERRLPDKAIDVIDEAGAFARIEAYKKESAGQNAEEPAVTEHSIQEASTSVGTIDIGLPLIETVISKIARI
PERSVGGREKDKLRELEEKLRTRIFGQDEAVTAVVKAVKRSRAGFRDANKPVANFLFVGPTGVGKTELARSLADIMGVSM
HRFDMSEYQEKHTVSRLIGSPPGYVGYEEGGLLTDAIRKQPHSVVLLDEIEKAHPDIYNILLQIMDYATLTDNNGRKADF
RNVVLIMTSNAGARDIGKNLIGFGERVMDESAVDGAVEKIFTPEFRNRLDAVVRFGHLSKEIMASIVTKELENFKGQLAE
KKVHLHVSEACIAQLAEEGYSREFGARNVGRVVEEKIKAFFVDEVLFGRLSEGGAARADYADGEFKIEILENEPVA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 5e-119 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpA YP_004527586.1 ATP-dependent Clp protease ATP-binding subunit ClpA VFG0080 Protein 5e-116 44
clpA YP_004527586.1 ATP-dependent Clp protease ATP-binding subunit ClpA VFG0079 Protein 9e-130 44