Gene Information

Name : Desku_2769 (Desku_2769)
Accession : YP_004518083.1
Strain : Desulfotomaculum kuznetsovii DSM 6115
Genome accession: NC_015573
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 2748208 - 2750133 bp
Length : 1926 bp
Strand : -
Note : TIGRFAM: ATPase, P-type, heavy metal translocating; ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating; ATPase, P type, cation/copper-transporter; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: mpd:MCP_1057 heavy metal translocating P

DNA sequence :
ATGTTCAGCTTCCCGTCACAAAGAGAAAGTGCCGTTCCCGTTGCCCCGGTTGGTGGCTTGTTCCGCCTGGAACGCTTGAG
GGAGCTGTGGGTGGCTTATGACAAGCTTATGATCACCCTGGGTTCTGGACTGCTCATCCTGCTGGGTTACCTGGCCGGCC
GCCTGGGCTGGCCGGCGGCGGCCAACGGGTTGATGGTGCTGGCCACTCTCCTGGCCGGCTACCGGGTTGCTGCGTCAGCC
TGGCAGGCTTTGCGCTTCCGGGTGGTGGGCATCAATGCCCTGGTTACCCTGGCTGCCCTGGGCGCCACCATTATCGGCGA
ATACTGGGAGGCGGCCGTGGTCACTTTTCTGTTTTCCCTGGGAAATTATCTGGAAGCCCGGACCATGGACAAAACCCGTG
CCGCTTTGAGGAAACTGATGGAGCTGGCGCCCCGGGTGGCCCGGGTGCGCCGGGAGGGAACCGAAGTGGAGGTGCCGGCG
GAAGAGGTGGAACCAGGCGAACTGGTCCTCATCCGTGCCGGGGATAAAATTCCGGTGGATGGCAGGGTGGTCAGGGGACG
GGCGACGGTCAATCAGGCGGCCATCACCGGGGAGTCCCTCCCGGTGCAGAAGGAGCCGGGGGATTATGTATTCAGCGGCA
CCATGAATGAAAGCGGCTACCTGGAGGTGGAAGCGGAACGAACCGGTGAGGAAACCACCTTTGCCCGGATCATGCAACTG
GTGGAAGAGGCCCAGGAGGAAAAGGCCAGGATCCAGCGCTGGCTGGAAAACTTCGCCCGTTACTATACTCCCGGGATTAT
GGCGGTTTCCGTCCTGACCTATCTGGTAACCCGGGATGCCCTGCTGGCCCTGACTCTGCTGGTGATTGCCTGTCCCGGGG
CGCTGGTGATTGCCACCCCCGTTTCCATTGTGGCCGCTACGGGAAATGCCGCCCGCCACGGGGTTCTGATCAAGGGCGGG
GAGCACCTGGAAAAGGCCGGACGGATCCGGGCGGTTGTTTTGGATAAAACCGGCACCCTCACCCGGGGCCAGCCGCTGGT
AAGAAAAGTGCGGGTGTGGCGCGGGTCGGAAAAGGAAATGTTGCTAAAAGCTGCTGCCGTGGAAAAACTGTCCGGACATC
CCCTGGCCAAACCCCTGGTGGAAAGGGCGGAGTCCCTGGGTGAAATCCCCCCGGCGGAAAATTTTCAGGTTCACCCCGGT
TACGGGGTAACCGGTACGGTGGACGGGGAGATTATCCGGGTGGGTAACCGCCGGTTGATGCAGGAAGCCAGCATCCCCGT
TCCGGTGGATGTGGAAAATTACCTGGCAGGCGAAGAGTCTGCCGGACGGACAGCCGTCCTGGTGGCCATAGGGGAGGAAA
TATGGGGAGCAGTGAGCATTGCCGACGGGATCCGGGACGAAGCGAAAAATCTGGTTTCCCGGTTGAAAGCCGCCGGAATA
CGCAGGGTGGTCATGCTCACCGGTGACAACCGGCGGGTGGCGCGGGCCGTGGCCCGGGAACTGGGAATGGACGAATACCA
GGCGGAGGTTTTGCCGGAAGGGAAAGTGGAGGCCATCCGTCGTTTGAAGCAAGAAGGCCTGGTGGTGGCCATGGTGGGGG
ACGGGATCAATGATGCCCCGGCCCTGGCGGCTGCCGATGTGGGTATTGCCATGGGGGTTGCAGGGGCCGACGTGGCTATG
GAAACGGCGGACATCGTTCTCATGTCCGACCGCCTGGATAAGCTCCCCTACGCCATCGGCCTCAGCCGGGAGACCTTGAA
AAATATCCGGCAAAATGTTACCTTTGCCATTCTGGTGGTGGCGGCTTTGCTGCTGGGTGTCATGGGCCAAAAGGTGGTGC
TGGCTTCCGGCATGCTTATCCATGAAGCCAGCGTACTCCTGGTCATCCTGAACGCCATGCGACTTATGCGTTACCGGAAT
GGATGA

Protein sequence :
MFSFPSQRESAVPVAPVGGLFRLERLRELWVAYDKLMITLGSGLLILLGYLAGRLGWPAAANGLMVLATLLAGYRVAASA
WQALRFRVVGINALVTLAALGATIIGEYWEAAVVTFLFSLGNYLEARTMDKTRAALRKLMELAPRVARVRREGTEVEVPA
EEVEPGELVLIRAGDKIPVDGRVVRGRATVNQAAITGESLPVQKEPGDYVFSGTMNESGYLEVEAERTGEETTFARIMQL
VEEAQEEKARIQRWLENFARYYTPGIMAVSVLTYLVTRDALLALTLLVIACPGALVIATPVSIVAATGNAARHGVLIKGG
EHLEKAGRIRAVVLDKTGTLTRGQPLVRKVRVWRGSEKEMLLKAAAVEKLSGHPLAKPLVERAESLGEIPPAENFQVHPG
YGVTGTVDGEIIRVGNRRLMQEASIPVPVDVENYLAGEESAGRTAVLVAIGEEIWGAVSIADGIRDEAKNLVSRLKAAGI
RRVVMLTGDNRRVARAVARELGMDEYQAEVLPEGKVEAIRRLKQEGLVVAMVGDGINDAPALAAADVGIAMGVAGADVAM
ETADIVLMSDRLDKLPYAIGLSRETLKNIRQNVTFAILVVAALLLGVMGQKVVLASGMLIHEASVLLVILNAMRLMRYRN
G

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 3e-98 44
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-98 42
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-98 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Desku_2769 YP_004518083.1 heavy metal translocating P-type ATPase BAC0183 Protein 8e-74 42
Desku_2769 YP_004518083.1 heavy metal translocating P-type ATPase BAC0098 Protein 4e-74 41
Desku_2769 YP_004518083.1 heavy metal translocating P-type ATPase BAC0461 Protein 2e-65 41
Desku_2769 YP_004518083.1 heavy metal translocating P-type ATPase BAC0101 Protein 1e-78 41
Desku_2769 YP_004518083.1 heavy metal translocating P-type ATPase BAC0298 Protein 9e-81 41
Desku_2769 YP_004518083.1 heavy metal translocating P-type ATPase BAC0124 Protein 2e-71 41