Gene Information

Name : Metme_2540 (Metme_2540)
Accession : YP_004513430.1
Strain : Methylomonas methanica MC09
Genome accession: NC_015572
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 2798267 - 2799970 bp
Length : 1704 bp
Strand : +
Note : PFAM: Amidohydrolase 1; Urease alpha-subunit, N-terminal; TIGRFAM: Urease, alpha subunit; HAMAP: Urease subunit alpha; KEGG: ttu:TERTU_4206 urease subunit alpha

DNA sequence :
ATGAGCAAAATCAGCCGACAAGCTTACGCCGACATGTTCGGCCCCACCACCGGCGACCGGGTACGCTTGGCCGATACCGA
TTTGATTCTGGAAGTGGAAGCCGATTACACCGTCTACGGCGACGAAGTGAAATTCGGCGGCGGCAAGGTGATCCGCGACG
GCATGGGCCAAAGTCAGCTGGGCTCCGAACACTCGGTGGATTTGGTGATTACCAACGCGCTGATCATCGACTACTGGGGT
ATCGTCAAGGCCGACGTCGGCGTCAAGGACGGCCGCATCTTCAAGATCGGCAAGGCCGGCAATCCGGATATTCAACCCGG
CGTGGACATCGTCGTCGGCCCCGGCACCGAAGTCATCGCCGGCGAGGGCCATATTCTGACCGCCGGCGGTATCGATGCGC
ACATCCATTTTATCTGCCCGCAGCAGATCGAAGAAGCGCTGTGCTCCGGCGTCACCACCATGATAGGCGGCGGCACCGGC
CCGGCCACCGGCACCAACGCCACCACCTGCACACCGGGGCCGTGGCATATTCAACAAATGTTGAAAGCCGTCGACGGTCT
GCCGATGAATATCGGCCTGCTGGGCAAGGGCAACGCCAGTCTACCCAGCGCCTTGGAAGAACAGGTCTTGGCCGGCGCTA
TGGGTCTGAAGCTGCACGAAGACTGGGGCACCACGCCAGCGGCGATCGATTGTTGTTTGAGCGTCGCCGAAGATTACGAC
GTGCAGGTGGCGATTCACACCGATACCCTGAACGAATCCGGTTTTGTCGAAGACACCATCGCCGCCTTCAAAGGCCGCAC
CATCCACACCTACCACACCGAAGGCGCCGGCGGCGGTCACGCCCCGGATATTATCAAGGCCTGCGGTTTGGCGAACGTAC
TGCCCTCCTCGACCAATCCGACCCGCCCCTACACGATCAACACCGTAGACGAGCATCTGGACATGCTGATGGTCTGCCAC
CACCTCGATCCCAGCATCCCGGAAGACGTGGCCTTCGCCGAATCGCGCATCCGCCGCGAAACCATTGCCGCCGAAGACAT
CCTGCACGACCTGGGGGCGTTTTCGATGATTTCTTCCGACTCGCAAGCCATGGGCCGGGTCGGCGAAGTGATTATTCGCA
CTTGGCAGACCGCGCATAAAATGAAGGTTCAGCGTGGCGCATTATCCGGCGACCCGGCGGCCAACGACAATCAACGCATC
AAGCGCTATATCGCCAAATACACCATCAACCCGGCCATCAGCCACGGTATTTCTCACGAGGTGGGTTCCATCGAAGCCGG
CAAGCTGGCCGATCTGGTGCTGTGGCAGCCGGCGTTTTTCGGCGTCAAACCCAGTTTAATATTAAAAGGCGGCTTGATTG
CCAGCGCGCCGATGGGCGACCCGAACGCGTCCATTCCCACCCCGCAACCGGTACACTACCGGCCTATGTTCGGCAGCTTC
GGCCGGGCCGCCGCCAATAACTCGATGATCTTTTTACCGCAGGTCGCTGTGAATTCCGGCGTTGCTGGGCAATTGGCGTT
GCAAAAGCGAGTCGGTACGGTAAGGAATACGCGGAACATTGGTAAGGCGGATATGAAGTTGAATGATTATCAGCCGGTGA
TGGAGGTTTGTTCGCAGACTTATCAGGTCAGGGCGGATGGGGTGTTGCTTACATGCGAACCGGCGGTGGTGTTGCCGATG
GCGCAGCGATATTTTTTGTTTTGA

Protein sequence :
MSKISRQAYADMFGPTTGDRVRLADTDLILEVEADYTVYGDEVKFGGGKVIRDGMGQSQLGSEHSVDLVITNALIIDYWG
IVKADVGVKDGRIFKIGKAGNPDIQPGVDIVVGPGTEVIAGEGHILTAGGIDAHIHFICPQQIEEALCSGVTTMIGGGTG
PATGTNATTCTPGPWHIQQMLKAVDGLPMNIGLLGKGNASLPSALEEQVLAGAMGLKLHEDWGTTPAAIDCCLSVAEDYD
VQVAIHTDTLNESGFVEDTIAAFKGRTIHTYHTEGAGGGHAPDIIKACGLANVLPSSTNPTRPYTINTVDEHLDMLMVCH
HLDPSIPEDVAFAESRIRRETIAAEDILHDLGAFSMISSDSQAMGRVGEVIIRTWQTAHKMKVQRGALSGDPAANDNQRI
KRYIAKYTINPAISHGISHEVGSIEAGKLADLVLWQPAFFGVKPSLILKGGLIASAPMGDPNASIPTPQPVHYRPMFGSF
GRAAANNSMIFLPQVAVNSGVAGQLALQKRVGTVRNTRNIGKADMKLNDYQPVMEVCSQTYQVRADGVLLTCEPAVVLPM
AQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 0.0 73
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 0.0 73
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-168 63
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-168 63
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-168 63
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-168 63

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Metme_2540 YP_004513430.1 urease subunit alpha VFG0270 Protein 1e-156 64