Gene Information

Name : megL (PGTDC60_1459)
Accession : YP_004510174.1
Strain : Porphyromonas gingivalis TDC60
Genome accession: NC_015571
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 1516129 - 1517328 bp
Length : 1200 bp
Strand : -
Note : similar to RefSeq{20100916}, gi|188995482|ref|YP_001929734.1| methionine gamma-lyase [Porphyromonas gingivalis ATCC 33277]|, percent identity 99.7 in 399 aa, BLASTP E(): 0

DNA sequence :
ATGAAAAAAGAAGACCTTATGCGTAGTGGCTTTGCCACACGTGCCATCCATGGAGGCGCTATCGAGAACGCCTTCGGCTG
CTTAGCCACTCCCATTTACCAAACATCGACTTTCGTTTTTGACACTGCCGAACAGGGAGGCCGCCGCTTTGCCGGAGAGG
AAGACGGATACATCTATACCCGTCTGGGCAACCCCAACTGCACCCAAGTGGAAGAGAAACTGGCCATGCTCGAAGGCGGA
GAAGCCGCCGCATCGGCCTCATCCGGTATCGGAGCCATCAGCTCTGCCATCTGGGTATGCGTGAAGGCCGGCGACCATAT
CGTAGCCGGCAAGACGCTCTACGGCTGCACCTTCGCCTTCCTCACCCACGGACTGAGCCGCTATGGTGTGGAAGTCACCC
TCGTGGATACCCGCCATCCGGAAGAGGTGGAGGCCGCCATTCGCCCGAATACGAAGCTCGTCTATCTGGAGACTCCGGCC
AACCCCAATATGTACCTGACCGACATCAAGGCAGTCTGCGACATCGCTCATAAGCACGAAGGCGTACGCGTCATGGTGGA
CAATACCTACTGCACGCCCTATATCTGCCGTCCGCTGGAGCTGGGTGCCGACATCGTGGTACACAGCGCGACCAAGTACC
TGAACGGACATGGCGACGTCATCGCCGGATTCGTCGTAGGTAAAGAGGACTACATCAAGGAGGTGAAGCTCGTCGGCGTC
AAGGACCTCACGGGGGCCAATATGAGTCCGTTCGATGCTTATCTGATCAGCCGCGGCATGAAGACGCTGCAGATACGTAT
GGAGCAGCACTGCCGCAATGCTCAGACCGTAGCCGAATTCCTCGAAAAGCATCCGGCCGTAGAAGCAGTTTATTTCCCCG
GACTTCCGAGCTTCCCCCAATACGAATTGGCCAAGAAGCAGATGGCACTGCCCGGAGCCATGATCGCCTTCGAAGTGAAG
GGCGGTTGCGAAGCCGGTAAGAAGCTGATGAACAGCCTGCACCTCTGCTCCCTCGCCGTGAGCTTGGGCGATACGGAAAC
CCTCATCCAGCATCCGGCCAGCATGACCCACTCGCCCTACACACCCGAAGAGCGTGCTGCCAGCGACATATCCGAAGGAC
TGGTACGTCTGTCCGTGGGTCTGGAAAACGTGGAGGACATCATCGCCGACCTCAAGCACGGTCTGGACAGCCTGATCTAA

Protein sequence :
MKKEDLMRSGFATRAIHGGAIENAFGCLATPIYQTSTFVFDTAEQGGRRFAGEEDGYIYTRLGNPNCTQVEEKLAMLEGG
EAAASASSGIGAISSAIWVCVKAGDHIVAGKTLYGCTFAFLTHGLSRYGVEVTLVDTRHPEEVEAAIRPNTKLVYLETPA
NPNMYLTDIKAVCDIAHKHEGVRVMVDNTYCTPYICRPLELGADIVVHSATKYLNGHGDVIAGFVVGKEDYIKEVKLVGV
KDLTGANMSPFDAYLISRGMKTLQIRMEQHCRNAQTVAEFLEKHPAVEAVYFPGLPSFPQYELAKKQMALPGAMIAFEVK
GGCEAGKKLMNSLHLCSLAVSLGDTETLIQHPASMTHSPYTPEERAASDISEGLVRLSVGLENVEDIIADLKHGLDSLI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-63 44
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-64 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_004510174.1 methionine gamma-lyase BAC0207 Protein 2e-102 57