Gene Information

Name : Mahau_1558 (Mahau_1558)
Accession : YP_004463569.1
Strain : Mahella australiensis 50-1 BON
Genome accession: NC_015520
Putative virulence/resistance : Resistance
Product : D-alanine--D-alanine ligase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : 6.3.2.4
Position : 1646354 - 1647436 bp
Length : 1083 bp
Strand : -
Note : COGs: COG1181 D-alanine-D-alanine ligase and related ATP-grasp protein; InterPro IPR000291: IPR011761: IPR005905: IPR011127: IPR 011095; KEGG: tmt:Tmath_2122 D-alanine/D-alanine ligase; PFAM: D-alanine--D-alanine ligase domain protein; PRIAM: D-alanine--D

DNA sequence :
TTGAATAAGAAGAAGATAGCGGTGTTATTCGGCGGCCGTTCGGGGGAGCATGAGGTGTCGCTTATGTCGGCCGTATCTGT
ACTTCGCAATATGGATAAAGATAAATACGAGCCGATTATGATAGGCATAACGAAAGAAGGGCGCTGGATGTTATATGAAG
GCGCTTTAGAAGATATAGAAGAAAATAGATGGCAAATATCAGCTCGGCCTGTTGTGCTCGCACCGGATCCATCATATAAG
GGATTTATAGATATAAAGCGCGACTGCACTTTTATACCCGTGGATGCTGTATTTCCTGTGTTGCATGGGCCTCATGGAGA
GGATGGTACAGTACAGGGGCTATTGGAATTGGCCGATATTCCATATGTGGGTTGCGGCGTGTTGGCATCGTCGCTGGCCA
TGGACAAGGTACTCTCCAAGGAAGTGTTTTTACGCCATGGATTAAGAGTGGCTGAGTATACCAGCACTATTTATGAACAT
TTTAAGGTCACCCCTAAGGTATTTGTATCAGTAGCTGAGACAAAGTTGGGTTATCCATGTTTCGTTAAACCTGCCAATAT
GGGTTCCAGCGTGGGTATTACCAAAGCTCATAACCGGGATGAACTGATGGAGGCTATAGAATTAGCGGGTAAATACGACC
GTAAGATACTTGTGGAGGAATTTATCGACGGGCATGAAATAGAATGTGCTGTGCTCGGCAACGATTATCCGGAGGCGTCA
ACTGTAGGCCAGATCGTACCGTGCAATGAATTTTATGATTATAATGCCAAATATTTTGATGAAGGCAAGTCCGGATTGGT
TATACCTGCCGATTTACCTATTGATGTCATGGAAGAGGTACGCAGGATGGCCGTCGAGGCTTATAGGGCTTTGGATTGCG
CCGGCATGGCTCGCGTGGATTTCTTGGTTAAAAAAAGCGATAATACAATATACCTTAACGAAGTGAATACCATACCGGGT
TTTACTAAAATAAGCATGTATCCTAAATTATGGGATGCCAGCAGCCTGCCTTACGATAAATTGATAGACCGTCTTATCGA
GCTGGCTTTTGAGCGATATCGACTGCAGCGCTCAGGTTATTAA

Protein sequence :
MNKKKIAVLFGGRSGEHEVSLMSAVSVLRNMDKDKYEPIMIGITKEGRWMLYEGALEDIEENRWQISARPVVLAPDPSYK
GFIDIKRDCTFIPVDAVFPVLHGPHGEDGTVQGLLELADIPYVGCGVLASSLAMDKVLSKEVFLRHGLRVAEYTSTIYEH
FKVTPKVFVSVAETKLGYPCFVKPANMGSSVGITKAHNRDELMEAIELAGKYDRKILVEEFIDGHEIECAVLGNDYPEAS
TVGQIVPCNEFYDYNAKYFDEGKSGLVIPADLPIDVMEEVRRMAVEAYRALDCAGMARVDFLVKKSDNTIYLNEVNTIPG
FTKISMYPKLWDASSLPYDKLIDRLIELAFERYRLQRSGY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 2e-53 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase AY489045.gene.p01 Protein 8e-54 43
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase AF277571.gene.p01 Protein 4e-54 43
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase AF130997.1.orf4.gene Protein 2e-53 43
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase U35369.1.gene6.p01 Protein 1e-53 41
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase AE016830.1.gene2250. Protein 1e-53 41
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase U00456.gene.p01 Protein 1e-53 41
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase NC_014475.1.orf3.gen Protein 6e-48 41
Mahau_1558 YP_004463569.1 D-alanine--D-alanine ligase NC_005054.2598280.p0 Protein 6e-48 41