Gene Information

Name : Trebr_0967 (Trebr_0967)
Accession : YP_004439534.1
Strain : Treponema brennaborense DSM 12168
Genome accession: NC_015500
Putative virulence/resistance : Virulence
Product : FliI/YscN family ATPase
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.14
Position : 1165581 - 1166939 bp
Length : 1359 bp
Strand : +
Note : COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterPro IPR005714:IPR003593:IPR004100:IPR000194; KEGG: tde:TDE1218 flagellum-specific ATP synthase FliI; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain

DNA sequence :
ATGAATTCTTTTTTTGATAAATACATTGCCAGCGTCAAAAACACGGAGACCATTTTATACACGGGAAACGTTTCCGCCGT
GCGCGGAATGCTCATTGAAAGTCACGGCCCCCGGTCGGTTATCGGTGAAATGTGTTTTATCAAACTGATGCGCGGCGACA
TGCAGATAGCGGCGGAAGTCGTCGGGCTGAACGGCACGACGGTGCAGCTGATGGCGTACGGTGAAACGAAAGGCATTGAA
ATCGGCTGCGAAGTGGTCGCTACCGGGCACGTCCTGCGGGTCGCCGTCGGAAACGGACTGTTGGGGCGCGTGATCGACGC
GGTCGGAAAACCGTACGACGGCAAGGGCGAATTGGCGTCCGGCCTGTATTATCCGGCGCTCGCGTCTCCGCCGGCTCCGC
TCGAGCGGCGTCCCGTTTCACAGCGCATGGTTACCGGTGTCCGCGCGATCGACGCAATGCTCGCCGTTGCGAAAGGGCAG
CGGCTCGGTATTTTTGCCGGTTCCGGCGTCGGAAAATCCACGCTTTTAAGTATGATCGCCCGAAACACAAAGGCGGACGT
CAACGTTATTGCGCTCGTCGGAGAGCGCGGGCGCGAAGTCGTCGATTTTATCGACCGCGATCTGGGCGAAGAAGGCTTGA
AGCGCTCCGTCGTCGTCGTCGCGACGTCCGACCAGCCGTCGATCGCCCGGTTACGCGCGGCGTATACGGCGACCGCGGTG
GCGGAATATTTCCGCGATCAGGGTAAAGACGTTATGCTCATGTTCGATTCGGTAACCCGGTTCGCTCACGCGCAGCGGGA
AATAGGACTCGCTTCCGGCGAACCGCCGGCGCAGCGCGGATATCCGCCGAGCGTGTTCGATCTGCTTCCGAAATTGCTTG
AACGCAGCGGTACCAATCAAACGGGTTCCATCACCGCGTTTTACACCGTACTGGTCGACGGCGACGATATGGACGAACCT
ATCGCCGACAAAGTGCGCGGTACGCTCGACGGACATATCGTTCTGAATCGGAAACTCGCCCAGGCGGCCCATTTTCCCGC
CATAGATGTGCTCGCGAGCATCAGCCGTCTGTCAAAACGGGTGTCCGGACCGGCAACGCAGCAGGCGGTTACGACGGTTC
GCCGGCTTATGGCGTCGTACGCCGAAAACGAAGACATGATCACCGTGGGAGCCTATCAGAAGGGCTCGAACGCCGCTATA
GACAAAGCGATCGACGTGCATCCCGATATAGAAGCTTTTCTTATGCAGGATGAATACGAGCCCGCGCCGCTGGAATCGAC
GCTCGAAAAGCTCGGTTCCATAGCCGGAACGGATATTCCGCCGGAGGAATGCGGAAGTTCCGCCGCCGCCGTTTCGTAA

Protein sequence :
MNSFFDKYIASVKNTETILYTGNVSAVRGMLIESHGPRSVIGEMCFIKLMRGDMQIAAEVVGLNGTTVQLMAYGETKGIE
IGCEVVATGHVLRVAVGNGLLGRVIDAVGKPYDGKGELASGLYYPALASPPAPLERRPVSQRMVTGVRAIDAMLAVAKGQ
RLGIFAGSGVGKSTLLSMIARNTKADVNVIALVGERGREVVDFIDRDLGEEGLKRSVVVVATSDQPSIARLRAAYTATAV
AEYFRDQGKDVMLMFDSVTRFAHAQREIGLASGEPPAQRGYPPSVFDLLPKLLERSGTNQTGSITAFYTVLVDGDDMDEP
IADKVRGTLDGHIVLNRKLAQAAHFPAIDVLASISRLSKRVSGPATQQAVTTVRRLMASYAENEDMITVGAYQKGSNAAI
DKAIDVHPDIEAFLMQDEYEPAPLESTLEKLGSIAGTDIPPEECGSSAAAVS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lscN AAO18044.1 LscN Virulence TTSS locus Protein 9e-95 51
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 8e-94 51
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-93 51
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 1e-88 50
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 2e-88 50
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-88 50
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-88 50
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-88 50
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-92 50
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 2e-92 50
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-93 50
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 1e-93 50
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 1e-93 50
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-91 49
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-91 49
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 3e-87 48
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 5e-80 48
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 5e-80 48
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 5e-76 46
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 8e-71 46
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 6e-78 46
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 6e-78 46
unnamed AAL06369.1 EscN Virulence LEE Protein 2e-79 46
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 6e-78 45
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 9e-85 45
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 4e-79 44
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 3e-78 44
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 2e-78 44
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-76 44
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-76 44
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 9e-74 44
escN NP_290268.1 hypothetical protein Virulence LEE Protein 6e-80 44
escN AAC31513.1 L0034 Virulence LEE Protein 4e-80 44
ECs4568 NP_312595.1 EscN Virulence LEE Protein 6e-80 44
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 4e-80 44
escN CAC81862.1 EscN protein Virulence LEE II Protein 2e-79 44
escN YP_003236088.1 translocator EscN Virulence LEE Protein 1e-80 44
escN AAK26715.1 EscN Virulence LEE Protein 1e-79 44
escN AAL57542.1 EscN Virulence LEE Protein 1e-79 44
escN AAC38383.1 EscN Virulence LEE Protein 6e-80 44
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 2e-79 44
escN CAI43874.1 EscN protein Virulence LEE Protein 2e-79 43
escN YP_003223475.1 translocator EscN Virulence LEE Protein 3e-79 43
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-71 42
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 2e-71 42
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-71 42
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-71 42
invC AAS66861.1 InvC Not tested SSR-2 Protein 4e-67 42
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 6e-71 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG2144 Protein 1e-96 53
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG0048 Protein 1e-92 50
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG0515 Protein 6e-89 50
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG0390 Protein 1e-94 49
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG0192 Protein 1e-94 48
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG2499 Protein 3e-83 48
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG2331 Protein 2e-77 46
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG1254 Protein 2e-89 46
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG2459 Protein 5e-75 44
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG0730 Protein 4e-80 44
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG0812 Protein 3e-80 44
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG0555 Protein 7e-72 42
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG1008 Protein 3e-65 42
Trebr_0967 YP_004439534.1 FliI/YscN family ATPase VFG1778 Protein 1e-69 42