Gene Information

Name : Thena_0176 (Thena_0176)
Accession : YP_004436956.1
Strain : Thermodesulfobium narugense DSM 14796
Genome accession: NC_015499
Putative virulence/resistance : Virulence
Product : FliI/YscN family ATPase
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.14
Position : 187717 - 189024 bp
Length : 1308 bp
Strand : +
Note : COGs: COG1157 flagellar biosynthesis/type III secretory pathway ATPase; InterPro IPR005714:IPR004100:IPR000194:IPR003593; KEGG: cth:Cthe_0468 flagellar protein export ATPase FliI; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding doma

DNA sequence :
GTGAAAAATCTCAAAGTTTTAAAAGATTTTATAGAAGATTATAATTATTTGCCCTGGAACGGGACAATTGATAAGATAAG
TGGTTATGTAATTGAATCAATTGGTCCAAAGGTTTCAATTGGGGAGATAGTATATATTGATTCAGGCAAGAGTCAAATTC
CATGTCTTGTTATCGGGTTTTCTTCAAATAAGGTTTATCTTACGCCATTTGATGCTATTGAAGGCATAGAGCCGGGCTCA
ATTGTAAAAAAGACCGGTAAGCAACTTGGCCTGTGGGTGGGAAAGCACCTTTTAGGTCAAGTTTTAGACGGTTTGGGAAG
ACCGTTGTCAGATGAATATATACAAAGAGATGACATGTCTCAATACAGATCAATTGAAAATAAGTCTCCACATCCTCTGA
AGAGAGGGAGAATAAGAGAGCCTATATCAACAGGCATTAGAGCTATTGATGGGCTCTTGACTTTGGGAAAGGGGCAAAGA
GTCGGGATCTTTGCAGGATCTGGTATTGGTAAGACTACCCTTCTTGGAATGATATCAAGATTTTGCAACGCACAGGTAAA
CATTATTGCTTTGGTTGGAGAAAGAGGTCGTGAGGTAAGAGAGTTTTTGGAAGAGAGTTTAGGAGAAGATGGACTTGCAA
AGTCTGTAGTGATAGTGTCCACATCAGATAATCCTCCTTCCCAAAGGGTTCTTTCTGCCTTTACTGCTACTGTTATAGCA
GAATATTTTAGGGACCTTGGGATGGACGTTCTTATGGTGATGGATTCTCTCACAAGAGTGTGTATGGCTCAAAGGGAGCT
AGGACTCTCAATAGGAGAGCCACCTACTACCAGAGGATATCCACCATCTGTTTTTACTATGATGGCAAGACTCTTAGAGA
GAGCTGGTACCTCTGATAAGGGTTCTATAACGGGCATCTATACTGTGCTTGTGGAGGGGGATGACCTTGCAGAACCAATA
GCAGATCACGCAAGAAGTATATTGGATGGTCACATAGTCCTGTCAAGAGACCTTGCTGAAAGGGGTTATTATCCTCCAAT
TGATATCTCACAGAGCGTAAGTAGGTTAATGAATTCTATCACGGACAAAGATCATCTAAATCTTAGTTATAGAATAAAAG
AGTTGATAGCCTCATATAAGGAAGCATATGATCTTATTAATATAGGTGCATATCAAAAAGGTTCAAATTCCAAGATTGAT
GAAAGTATAGAAAAAATATCAAAAATAGAAGAATTTTTGAAACAAACTCCTGAAGACATTTCAAGCTTTGATGACACTCG
TAGACTTTTGGAGGAGATATTACTATGA

Protein sequence :
MKNLKVLKDFIEDYNYLPWNGTIDKISGYVIESIGPKVSIGEIVYIDSGKSQIPCLVIGFSSNKVYLTPFDAIEGIEPGS
IVKKTGKQLGLWVGKHLLGQVLDGLGRPLSDEYIQRDDMSQYRSIENKSPHPLKRGRIREPISTGIRAIDGLLTLGKGQR
VGIFAGSGIGKTTLLGMISRFCNAQVNIIALVGERGREVREFLEESLGEDGLAKSVVIVSTSDNPPSQRVLSAFTATVIA
EYFRDLGMDVLMVMDSLTRVCMAQRELGLSIGEPPTTRGYPPSVFTMMARLLERAGTSDKGSITGIYTVLVEGDDLAEPI
ADHARSILDGHIVLSRDLAERGYYPPIDISQSVSRLMNSITDKDHLNLSYRIKELIASYKEAYDLINIGAYQKGSNSKID
ESIEKISKIEEFLKQTPEDISSFDDTRRLLEEILL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lscN AAO18044.1 LscN Virulence TTSS locus Protein 4e-83 49
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 2e-79 49
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-78 49
unnamed AAL06369.1 EscN Virulence LEE Protein 1e-77 47
escN YP_003236088.1 translocator EscN Virulence LEE Protein 8e-77 47
escN NP_290268.1 hypothetical protein Virulence LEE Protein 6e-77 47
escN AAC31513.1 L0034 Virulence LEE Protein 5e-77 47
ECs4568 NP_312595.1 EscN Virulence LEE Protein 6e-77 47
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 5e-77 47
escN YP_003223475.1 translocator EscN Virulence LEE Protein 1e-77 47
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 1e-77 47
escN CAI43874.1 EscN protein Virulence LEE Protein 9e-78 47
escN CAC81862.1 EscN protein Virulence LEE II Protein 8e-78 47
escN AAK26715.1 EscN Virulence LEE Protein 8e-78 47
escN AAL57542.1 EscN Virulence LEE Protein 8e-78 47
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 8e-79 46
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 6e-79 46
escN AAC38383.1 EscN Virulence LEE Protein 2e-77 46
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 3e-75 46
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 6e-79 45
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 4e-79 45
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 4e-79 45
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-74 45
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-74 45
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-77 45
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-77 45
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-72 45
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 3e-72 45
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-72 45
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-72 45
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 2e-72 45
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 6e-71 44
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 2e-66 44
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 6e-72 44
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 2e-73 44
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 8e-69 44
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 3e-69 44
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 1e-69 44
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 1e-67 43
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-59 42
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 3e-59 42
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-59 42
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-59 42
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 2e-68 42
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-68 42
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 5e-62 42
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 5e-62 42
invC AAS66861.1 InvC Not tested SSR-2 Protein 8e-57 41
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 2e-59 41
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 4e-59 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG0192 Protein 7e-85 50
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG0390 Protein 2e-85 49
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG2144 Protein 3e-85 49
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG1254 Protein 7e-82 49
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG0812 Protein 3e-77 47
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG2331 Protein 1e-76 47
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG2499 Protein 3e-78 47
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG0048 Protein 1e-81 46
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG0730 Protein 1e-77 46
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG0515 Protein 2e-72 45
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG0555 Protein 1e-59 42
Thena_0176 YP_004436956.1 FliI/YscN family ATPase VFG1008 Protein 7e-58 41