Gene Information

Name : Marky_0398 (Marky_0398)
Accession : YP_004367261.1
Strain : Marinithermus hydrothermalis DSM 14884
Genome accession: NC_015387
Putative virulence/resistance : Resistance
Product : D-alanine--D-alanine ligase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : 6.3.2.4
Position : 381187 - 382161 bp
Length : 975 bp
Strand : +
Note : COGs: COG1181 D-alanine-D-alanine ligase and related ATP-grasp protein; HAMAP: D-alanine--D-alanine ligase; InterPro IPR005905:IPR011127:IPR011095; KEGG: msv:Mesil_0661 D-alanine/D-alanine ligase; PFAM: D-alanine--D-alanine ligase, C-terminal; D-alanine--

DNA sequence : 
ATGAGTAAATTACGTATATTACTCATCGCCGGGGGGCGTTCGGGGGAGCACGAGGTCTCCCTCGCCTCGGCGCGGGGGGT
GTTGGAGGCCATGCCCCACCCCACCGACCTCGCGGTGATCGCGAAGGACGGGCGGTGGCTTACGGGAACTGCCGCCCGGG
CGGCGCTCGAGGCGGGCCGGGCGCAGCGCGGCGAGCACCCCTTCCCGCCGCCCCTTTCCTGGCATCGTTACGACGTGGCC
TTCCCCTTGCTGCACGGCCGTTGGGGGGAGGACGGCACGATCCAGGGGTTTTTGGAGATGCTGGGGCTGCCCTACGTAGG
AGCCGGGGTGGGGGCCGCCGCGCTATGCATGGACAAGGAGCTTACGAAACGCACCCTGGCGCACGCGGGCATCCCCGTGG
TGCCTTGGGTGAGCCTGTGGCGAGGCGAGGGCCTGCCCGAGCTGCCCTTTTCCCCGCCGTACTTCGTCAAGCCCGCGAAC
ACTGGCTCGTCCGTAGGGATCTCCAAGGTGCGCACCCGCGAGGCGCTCGGACCGGCCCTCGAGGAGGCCTTCCGCTGGGA
CGACCGGGTCCTGGTGGAGCAGGGGCTGGAGGGGGTGCGCGAGCTCGAGGTGGCCCTTTTGGGCAACGTGACGGCCGAGG
CGAGCGTGGTGGGGGAGGTCCGTTACCAGAGCGAGTTCTACGATTACGCGACCAAGTACACCCCGGGACGGGCCGAGCTC
CTGATTCCCGCGCCTGTAGACGCGGACGTGGCGCGCCGCCTTCAGGAGGTCGCCCGGACGGCCTACCGCCTTCTCGGGGT
GCGCGGCCTGGCGCGCGTGGACTTCTTCCTCGCCCCGGATGGGGCGCTCTACCTCAACGAGCTCAACACCATGCCCGGGT
TCACCCCGACGAGCATGTACCCCAAGCTCTGGCAGGCCTCGGGGCTGGAGTACGAAGCGTTGCTCGAGCGGCTCGTACGC
CTCGCGCTTGAGTGA

Protein sequence : 
MSKLRILLIAGGRSGEHEVSLASARGVLEAMPHPTDLAVIAKDGRWLTGTAARAALEAGRAQRGEHPFPPPLSWHRYDVA
FPLLHGRWGEDGTIQGFLEMLGLPYVGAGVGAAALCMDKELTKRTLAHAGIPVVPWVSLWRGEGLPELPFSPPYFVKPAN
TGSSVGISKVRTREALGPALEEAFRWDDRVLVEQGLEGVRELEVALLGNVTAEASVVGEVRYQSEFYDYATKYTPGRAEL
LIPAPVDADVARRLQEVARTAYRLLGVRGLARVDFFLAPDGALYLNELNTMPGFTPTSMYPKLWQASGLEYEALLERLVR
LALE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 6e-39 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Marky_0398 YP_004367261.1 D-alanine--D-alanine ligase U00456.gene.p01 Protein 3e-39 42
Marky_0398 YP_004367261.1 D-alanine--D-alanine ligase U35369.1.gene6.p01 Protein 3e-39 42
Marky_0398 YP_004367261.1 D-alanine--D-alanine ligase AE016830.1.gene2250. Protein 3e-39 42