Gene Information

Name : Marky_0365 (Marky_0365)
Accession : YP_004367228.1
Strain : Marinithermus hydrothermalis DSM 14884
Genome accession: NC_015387
Putative virulence/resistance : Resistance
Product : beta-lactamase domain-containing protein
Function : -
COG functional category : R : General function prediction only
COG ID : COG0491
EC number : -
Position : 351488 - 352930 bp
Length : 1443 bp
Strand : -
Note : COGs: COG0491 Zn-dependent hydrolase including glyoxylase; InterPro IPR001279:IPR001763; KEGG: ttj:TTHA0837 metallo-beta-lactamase; PFAM: beta-lactamase-like; Rhodanese-like; SMART: beta-lactamase-like; Rhodanese-like; SPTR: Metallo-beta-lactamase; PFAM:

DNA sequence :
ATGCTCTTCAAACCCTTCTACGAGGAAAGCCTGGCCATCGCGTCCTACATGATCGGCTGTCCGGCCACCGGAGAGGCCCT
CGTCGTGGACCCGACCCGCGACATCGAGGCCTACCTCCAGGAAGCCCAAAAGCACAAACTACGGATCGTCGCGGTCACCG
AGACCCACATCCACGCCGACTACCTCTCCGGCGCCCGCGAGCTCGCCAAGGCCACCGGCGCCACCCTCTACCTCTCCGAC
GAAGGCGACGAAAACTGGAAGTACCAGAACCTGGACGGCTTCAAGTACGTCCTCGTCAAGGACGGCGACGAGATCCGCAT
CGGTAACGTCCGTGTCCAGGTGGTCCACACCCCCGGCCACACCCCCGAGCACATCTCCTTCCTCGTCACCGACGGCGCCG
CCGCGGATGAGCCCATGCTCTTCCTCACCGGCGACTTCGTCTTCGTAGGCGACGTGGGCCGCCCCGACCTCCTCGAGGAG
GCCGCCGGCATCCAAGGGACCGCCGAGCCGGGGGCGCGCCGCATGTTCCACAGCCTCAAGACCAAGTTCCTCACCCTCCC
CGACCATGTCCAGGTCTGGCCCGGCCACGGCGCCGGCTCCGCCTGCGGCAAGGCCCTCGGTGCCCTCCCCAGCACCACCG
TCGGGTACGAGCGCCGCTTCGCCTGGTGGGCCACGTACCTCGAGAAAGACGACGAGGAAGGGTTTGTCCGGGCGCTCCTC
CAGGACCAGCCCGAAGCCCCCAGTTACTTCGCCCAGATGAAGCGCCTCAACCGCGACGGTGCCCCGCTACTGGGCGGCAT
CCCGCACCCCGCGCGCCTCACCCCCACCCAGTTCCACAAGGCCCTCGCCGAAGGCGCGGTTCTGGTGGACACCCGCGACA
AGTACGCCTTCGCCGGCGGGCACCTCAAAGGCGCGATCAACATCCCCGCCGGGAGGAACTTCACCACCTGGGCCGGCTGG
CTCCTCCCCTACGACAAGCCCCTCATCCTCCTCGCTGCGCCGGAGCTGCTCGAGACCCTGACCCGTCACCTGATCCGCAT
CGGGTTGGACAACATCGCCGGGTACATCCCCACCCTCGAGGGGTACGTCGAGGGCGAGCTCGAGACCGTACCCCAGGTCA
CCGCAGCCGAGGCCAAGGCCATGTGGGAGCGGGGCGAGGCCCACGTCCTCGATGTGCGCGGCGCCCAGGAGTACCGCGCG
GGCCACATCCCCGGCGCCCTCCACATCCACGCCGGTCGCGTGATGCGGCACCTGGAGCAGCTCCCCACCAATAAACCCCT
CATCGTCTACTGCCAGGGCGGGGACCGCTCGAGCACTGCGATCAGCGCCCTGCTGGCCGCCGGGTTCCGCAACGTCGTGA
ACCTCACCGGCGGCTTCCAGGCCTGGCACACCCAAGGCTTCCCCGTGGATAAAGGCCAAGAGACCGCCGAGGCCGCCATC
TAA

Protein sequence :
MLFKPFYEESLAIASYMIGCPATGEALVVDPTRDIEAYLQEAQKHKLRIVAVTETHIHADYLSGARELAKATGATLYLSD
EGDENWKYQNLDGFKYVLVKDGDEIRIGNVRVQVVHTPGHTPEHISFLVTDGAAADEPMLFLTGDFVFVGDVGRPDLLEE
AAGIQGTAEPGARRMFHSLKTKFLTLPDHVQVWPGHGAGSACGKALGALPSTTVGYERRFAWWATYLEKDDEEGFVRALL
QDQPEAPSYFAQMKRLNRDGAPLLGGIPHPARLTPTQFHKALAEGAVLVDTRDKYAFAGGHLKGAINIPAGRNFTTWAGW
LLPYDKPLILLAAPELLETLTRHLIRIGLDNIAGYIPTLEGYVEGELETVPQVTAAEAKAMWERGEAHVLDVRGAQEYRA
GHIPGALHIHAGRVMRHLEQLPTNKPLIVYCQGGDRSSTAISALLAAGFRNVVNLTGGFQAWHTQGFPVDKGQETAEAAI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed BAB83478.1 - Not tested SCC 12263 Protein 2e-80 43
SACOL0046 YP_184956.1 metallo-beta-lactamase Not tested Type-I SCCmec Protein 1e-80 42
unnamed BAA86645.1 hypothetical protein Not tested Type-I SCCmec Protein 1e-80 42