Gene Information

Name : Marky_0292 (Marky_0292)
Accession : YP_004367159.1
Strain : Marinithermus hydrothermalis DSM 14884
Genome accession: NC_015387
Putative virulence/resistance : Resistance
Product : dihydropteroate synthase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0294
EC number : 2.5.1.15
Position : 283777 - 284604 bp
Length : 828 bp
Strand : -
Note : COGs: COG0294 dihydropteroate synthase; InterPro IPR006390:IPR000489; KEGG: msv:Mesil_0310 dihydropteroate synthase; PFAM: Pterin-binding; PRIAM: dihydropteroate synthase; SPTR: dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin bin

DNA sequence :
GTGGTTCTCGAGCTTCGCGAGCACGCCCTCGACCTCACGCGCGTTCGCCTCATGGGAGTGCTGAACGTCACCCCGGACTC
CTTCTCCGACGGCGGGCGGTACCTCACGGTGGAGGCCGCCCTCCTCCAGGCCCGCCGGATGATCGCGGAAGGCGCGGACC
TGATCGACCTGGGCGGCGAGTCCACCCGCCCCGGCGCCCAACCGGTGCCGGTCGAGGAGGAGAAGCGCCGGGTGCTCCCG
CTCCTAGAAGCCCTCCTCGAGCTCGGGGTCCCCATCAGCGTCGACACCCGCAAGCCCGAGGTGGCTCAGGCAGCGCTCGA
GCTGGGCGCGCACCTCCTCAACGACGTGACCGGCCTGCGCGACGCGCGCATGCTCGAGCTCGCCGCGCGGTACCGGGTGC
CCGTGGTGATCATGCACATGCCCGTACCGGACCCCCAAACGATGATGCAGCACGCCCACTACGACGACGTGGTCGCCGAG
GTCAAGGCCTTCCTCGCTCGCCAAGCCGCGCGGGCCATCGAGGCGGGCGTCCCTCAGGTGGTGCTCGACCCGGGGATCGG
GTTCGGCAAGCGCCTCGAGCACAACCTCGAGCTGATCCGCCGCTTGGACGAGCTCGCGGCCCTGGGGCACCCGGTCCTGC
TCGGCGCGAGCCGGAAACGCATGATCGGGGAGCTCACGGGCGTCGAAGCCCCAGCCGAGCGCGTCCTGGGCACGGTCGCG
GCGCACCTTTACGGCGCGGCGCGCGGGGCGCATATCCTCCGGGTGCACGACGTGCGGGCGCACCGCGAGGCCCTCGCGGT
CTGGGAAGCGCTCGAGGGGGGGCGGTGA

Protein sequence :
MVLELREHALDLTRVRLMGVLNVTPDSFSDGGRYLTVEAALLQARRMIAEGADLIDLGGESTRPGAQPVPVEEEKRRVLP
LLEALLELGVPISVDTRKPEVAQAALELGAHLLNDVTGLRDARMLELAARYRVPVVIMHMPVPDPQTMMQHAHYDDVVAE
VKAFLARQAARAIEAGVPQVVLDPGIGFGKRLEHNLELIRRLDELAALGHPVLLGASRKRMIGELTGVEAPAERVLGTVA
AHLYGAARGAHILRVHDVRAHREALAVWEALEGGR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
sul2 AEA34678.1 dihydropteroate synthase Not tested Not named Protein 1e-28 42
sulI2 AFV47959.1 sulphonamide-insensitive dihydropteroate synthase SulI2 Not tested AbaR25 Protein 1e-28 42
sul2 AEZ06044.1 Sul2, sulphonamide-insensitive dihydropteroate synthase Not tested Tn6167 Protein 1e-28 42
BJAB07104_00246 YP_008207711.1 Dihydropteroate synthase-related enzyme Not tested AbaR25 Protein 1e-28 42
BJAB0868_00253 YP_008211579.1 Dihydropteroate synthase-related enzyme Not tested AbaR26 Protein 2e-28 42
ABK1_0255 YP_005512827.1 Dihydropteroate synthase type-2 Not tested AbaR4d Protein 1e-28 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_008702.1.4608834. Protein 5e-46 50
Marky_0292 YP_004367159.1 dihydropteroate synthase CP002695.1.gene1085. Protein 1e-49 49
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_002516.2.881715.p Protein 6e-44 49
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_002695.1.916103.p Protein 5e-46 49
Marky_0292 YP_004367159.1 dihydropteroate synthase CP000034.1.gene3358. Protein 6e-45 49
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_011595.7059722.p0 Protein 3e-41 48
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_011586.7045137.p0 Protein 3e-41 48
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_010410.6003232.p0 Protein 3e-41 48
Marky_0292 YP_004367159.1 dihydropteroate synthase CP001138.1.gene3456. Protein 8e-44 48
Marky_0292 YP_004367159.1 dihydropteroate synthase CP004022.1.gene3451. Protein 3e-49 47
Marky_0292 YP_004367159.1 dihydropteroate synthase CP000647.1.gene3624. Protein 2e-44 47
Marky_0292 YP_004367159.1 dihydropteroate synthase AM180355.1.gene1650. Protein 3e-43 47
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_010400.5986775.p0 Protein 8e-42 47
Marky_0292 YP_004367159.1 dihydropteroate synthase AE000516.2.gene3902. Protein 2e-33 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_002745.1123263.p0 Protein 3e-39 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_013450.8613224.p0 Protein 3e-39 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_003923.1002573.p0 Protein 7e-40 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_007622.3794340.p0 Protein 1e-38 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_002758.1120474.p0 Protein 3e-39 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_009782.5559617.p0 Protein 3e-39 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_002952.2860679.p0 Protein 3e-39 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_007793.3915320.p0 Protein 7e-40 46
Marky_0292 YP_004367159.1 dihydropteroate synthase CP000675.2.gene3019. Protein 2e-47 46
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_009641.5330254.p0 Protein 3e-38 45
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_002951.3237126.p0 Protein 7e-39 45
Marky_0292 YP_004367159.1 dihydropteroate synthase DQ464881.1.gene2.p01 Protein 5e-28 42
Marky_0292 YP_004367159.1 dihydropteroate synthase NC_012469.1.7686560. Protein 3e-28 42
Marky_0292 YP_004367159.1 dihydropteroate synthase AE016830.1.gene3181. Protein 2e-40 41