Gene Information

Name : Marky_2015 (Marky_2015)
Accession : YP_004368853.1
Strain : Marinithermus hydrothermalis DSM 14884
Genome accession: NC_015387
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 2026670 - 2028040 bp
Length : 1371 bp
Strand : +
Note : COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR021179:IPR013027:IPR004099; KEGG: msv:Mesil_1148 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine n

DNA sequence : 
ATGGCGTACGACCTGATCGTGATCGGCAGCGGCTCGGCGGGCATGGGCGCGGCCCTGGAGGCCAAGGAACGCGGCGCGCG
CGTGCTGGTCGTCGAGGCCGGCACGATCGGCGGTACCTGCGTCAACGTGGGGTGCGTCCCCTCCAAAACCCTCCTGCGCG
CCGCCGAGGCCTACCACAAGGCCACCCACTCCCCCTTCGCCGGGGTGCGCCCCAAAGGCGCCGCGCTCGACTTCGCCGAG
GTCCTCCGCCAAAAAGACGCCCTGATCCAAACCCTCCGCCAGGAGAAGTACGCCGACGTCCTCGAGGCCGCCGGCGTCCC
CCTCCTCCAGGGCACGGCCCGCTTCCTGGACGCCGAACGGCTCTCGGTGGGCGACCAGGTCCTCACGGCCGGCGCCTACG
TCCTCGCCACCGGCGCCACCCCCACCCTCCCCCCCATCCCCGGCCTCGCGGAGGCCCGGCCCTGGACGTACATCGAAGCC
CTCTCCCCCGAGGCCCTGCCCGAAAGCCTCGTCGTGATCGGCGGGGGACCCATCGGCCTCGAGCTCGCCCAGGCCTACGC
CCGCTTCGGCACCCGCGTCACGGTCCTCGAGGCCCTGCCGTACCTGCTGCCCGCCGAGGACCCCGAGCTCACCACCGCCC
TCCGCGGGTACCTGACGGCTGAAGGCCTCGAGATCCACACGAACGCCCAGGTGACCCGCGTCGAACGCGACGGAGCCTAC
CGCGTGCACACCCCAAACGGCGTGTACACCGCCGAGCGCCTCCTCGTCGCCACCGGCCGCCGCGCGCGCACCCAAGGCCT
CGGCCTCGAGGCCGCCGGCGTGGAGGTGGGCCGGGCCGGTGAGGTGCGGGTGGACGCGCACCTCCGCTCCACCAACCCAC
GCATCTTCGCCGCGGGGGACGTGGCGGGCCTGCCGCAGTTCGTTTACGTGGGGGCCCAGTCCGGGCGCGTCGCCGCCCGG
AACGCGCTGGGGGAGGAAACCCCCCTGGACCTCACCGCCGTACCCCGCGTCACCTTTACCGACCCCGCCCTGGCCGCGGT
CGGCCTCACGGAGGAGGCCGCGCGGCAGGCCCACGGGGAGGTGCGGGCCGCCCGGCTGCCGCTCGAGGCCGTCCCCAAGG
CCCTCGCCGCGGCGGACACTCGGGGCCTGATCAAACTCGTGGTGGACGCACAAGGCACCGTGCTCGGCGTGCACGTCCTC
GCGCCCGAGGCCGGGGAGGTGCTGCAGGAAGGCATCCTCGCGGTGAAGCACGCCCTGCATTACCGCGACCTGATCGACAC
CTTCCACCCCTACCTCACCCTCGCGGAAGGGCTCCGGCTGGTCGCGCAAGCGCTGGACACCGACGTGCACAAGCTCTCCT
GCTGCGCATGA

Protein sequence : 
MAYDLIVIGSGSAGMGAALEAKERGARVLVVEAGTIGGTCVNVGCVPSKTLLRAAEAYHKATHSPFAGVRPKGAALDFAE
VLRQKDALIQTLRQEKYADVLEAAGVPLLQGTARFLDAERLSVGDQVLTAGAYVLATGATPTLPPIPGLAEARPWTYIEA
LSPEALPESLVVIGGGPIGLELAQAYARFGTRVTVLEALPYLLPAEDPELTTALRGYLTAEGLEIHTNAQVTRVERDGAY
RVHTPNGVYTAERLLVATGRRARTQGLGLEAAGVEVGRAGEVRVDAHLRSTNPRIFAAGDVAGLPQFVYVGAQSGRVAAR
NALGEETPLDLTAVPRVTFTDPALAAVGLTEEAARQAHGEVRAARLPLEAVPKALAAADTRGLIKLVVDAQGTVLGVHVL
APEAGEVLQEGILAVKHALHYRDLIDTFHPYLTLAEGLRLVAQALDTDVHKLSCCA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 2e-81 47
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 1e-86 46
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 7e-87 46
merA ABQ57371.1 MerA Not tested SGI1 Protein 5e-84 46
merA AGK07021.1 MerA Not tested SGI1 Protein 5e-84 46
merA AGK07079.1 MerA Not tested SGI1 Protein 5e-84 46
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 2e-83 46
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 1e-83 46
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 6e-81 45
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 2e-81 44
merA AFG30120.1 MerA Not tested PAGI-2 Protein 2e-81 44
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 3e-81 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Marky_2015 YP_004368853.1 mercuric reductase BAC0651 Protein 4e-87 46
Marky_2015 YP_004368853.1 mercuric reductase BAC0224 Protein 3e-85 46
Marky_2015 YP_004368853.1 mercuric reductase BAC0652 Protein 3e-84 45
Marky_2015 YP_004368853.1 mercuric reductase BAC0653 Protein 7e-81 45
Marky_2015 YP_004368853.1 mercuric reductase BAC0650 Protein 6e-74 42