Gene Information

Name : Marky_1674 (Marky_1674)
Accession : YP_004368519.1
Strain : Marinithermus hydrothermalis DSM 14884
Genome accession: NC_015387
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1693719 - 1694915 bp
Length : 1197 bp
Strand : -
Note : COGs: COG0626 cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: opr:Ocepr_1578 cys/met metabolism pyridoxal-phosphate-dependent protein; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: cystathionine ga

DNA sequence :
ATGAAGACGAAACGCTTTCGGACGCGCGCCGTGCACAGCGGCCAACGCCCCGATCCGCTCACCGGCGCGCACGCGACTCC
CATCTACCAGACCTCGACCTTCGCTTACGGCTCCTTCGATCGCGGCGCTCGGCTATTCGCTGGCGAGGAGACGGGCTTCC
TCTACAGCCGCATCGGGAACCCCACCACGCGCAGCTTCGAGGAGAAACTCGCGGACCTCGAGGGCGCGGAAGACGCGGTG
GCCTTCGCGAGCGGCATGGCCGCGGTGAGCGCCCTAGCCCTCACGCTGCTCCGGCCCGGGGACGAGGTGGTCTTTATCGG
CCCGCTCTATGGCGGCACCGAGGGGTTCTTCCTGGACGTGCTCGCGCGTTTCGGGGTCACCATTACGGACGCCACGGGCT
ACGAGAGCCTGGAAGCGGCCCTCTCCCCGGCCACCCGCATGATCTACGTCGAGACCCCCTCCAACCCCACCCTCCGGATC
ACGGACCTGGCCGAGGTTGCCCGGATCGGCCGGGCGCGCGGGATCCTCACCGTCGCGGACAACACCTTCGCCACCCCCTA
CCTCACCCGCCCCCTCGAGCACGGAATCGACCTCGTCCTGCACTCCGCCACCAAGTACCTGGGCGGGCACGGGGACGCGG
TCGGCGGGATCCTTGCCGGGCCCAAGGAGATCGTGGACCAGGTGCGGGCCGAGGGGCTGCGGCACGTCGGGGGCAGCCTG
GGGCCTTTGGAAAGCTACCTCTTCCTCCGCGGCATGAAAACCCTCCCCTTGCGCATGGAGGCGCACTGCGACGGGGCGGA
GGCCGTCGCCGCCTACCTCAAGGCCCACCCCCTGGTACGGCGGGTCCACTACCCGGGCCTGCCCGAGCACCCGAACCACG
CGGTCGCCGCCCGCCAGATGCGCCGGTTCGGGGGGATGGTCAGCTTCGAGCTCGAGGGTGGGGCGCGCGCGGCTCGTGCT
TTCCTCGATAGCCTCGAGCTCTTCCTCCAGGCGGTTTCCTTGGGGGATGTGGAGTCCCTCGCCACTCACCCCGCCTCCAC
CACGCACCAGCTGCTGCCCCCGGACGTCCTCGAGCGCCAGGGGGTCACGGACGGGCTGGTGCGCCTCTCCATCGGCATCG
AGGACCCCGAGGACCTGATCGCGGACCTCGAGCAGGCCCTCGCGCGGGTCGAACAGGTCCTGGAGCGGGCCGGGTGA

Protein sequence :
MKTKRFRTRAVHSGQRPDPLTGAHATPIYQTSTFAYGSFDRGARLFAGEETGFLYSRIGNPTTRSFEEKLADLEGAEDAV
AFASGMAAVSALALTLLRPGDEVVFIGPLYGGTEGFFLDVLARFGVTITDATGYESLEAALSPATRMIYVETPSNPTLRI
TDLAEVARIGRARGILTVADNTFATPYLTRPLEHGIDLVLHSATKYLGGHGDAVGGILAGPKEIVDQVRAEGLRHVGGSL
GPLESYLFLRGMKTLPLRMEAHCDGAEAVAAYLKAHPLVRRVHYPGLPEHPNHAVAARQMRRFGGMVSFELEGGARAARA
FLDSLELFLQAVSLGDVESLATHPASTTHQLLPPDVLERQGVTDGLVRLSIGIEDPEDLIADLEQALARVEQVLERAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 4e-64 45
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-63 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-64 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Marky_1674 YP_004368519.1 cystathionine gamma-synthase BAC0207 Protein 1e-89 50