Gene Information

Name : Marky_1279 (Marky_1279)
Accession : YP_004368129.1
Strain : Marinithermus hydrothermalis DSM 14884
Genome accession: NC_015387
Putative virulence/resistance : Virulence
Product : betaine-aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.8
Position : 1274429 - 1275877 bp
Length : 1449 bp
Strand : +
Note : COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: bcl:ABC0047 aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase domain; PRIAM: betaine-aldehyde dehydrogenase; SPTR: Aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase

DNA sequence :
ATGCTAAACGAGACGAAAGCCTTCTTGGACCGGCCTAAGAAGCTCTACATTGGCGGCGAGTGGGTGGACGGCGAGGGCAC
CTTCCCCACCCATAACCCCGCGACCGGGGAGGTGCTGGCCGAGGTCCCGTACGGCGGTCAGGCCGCAGTGCACCAGGCGG
TCGAGGCCGCGCGCGCGGCCTTCCCGGGCTGGAGCCAGCTCCCACCCCTCGAGCGCAGCCGGTGGCTGAACCGGATCGCC
GACGCGATCGAGGCGCACGCGGACGAGCTCGCGGAGATCGAAACCCTGGATAACGGCAAGCCCATCCGCGAGTCCCGGCG
GGGGGATATTCCCCTCGCGGCGATGCATTTCAGGTACTACGCGGGCCTCGCCCCCACCGTAGGCGGACGGACCGTGCCGG
TGAGCGCGCCCGGCGTGTTCAACTACACGCTGCGCGAACCGGTGGGCGTGGTGGGCGCGATCGTCCCCTGGAACTTCCCC
CTGCTCATCGCGACCTGGAAGCTCGCCCCCGCCCTCGCCGCGGGGTGCACGGTGGTCCTCAAGCCCGCCGAGGAGACGCC
CCTCACCGCGCTGCGCCTCGCGGAGATCCTCGAGGAAATCGGGTTCCCCAAGGGCGTGGTCAACGTCGTGACCGGGGACG
GCCAGACCGGCGCGAAGCTCGTCCAGCACCCCGGGGTGGACAAGATCACCTTCACCGGCAGCACCGAGGTCGGCAAGATC
ATCATGCGCGAGGCCGCGGACCGCATCGCGCGGGTCTCCCTCGAGCTCGGCGGCAAGTCCGCGAACATCGTGTTCGAGGA
CGCGGACCTCGACGCGGCCGTGAAAGGCGCGGGGATCGGGATCTTCTACAATCAAGGCCAGCTCTGCACCGCGGGGAGCC
GCATCCTGGTGCAAAAAAGCGTCCTCGAGCCGTTCCTCGAACGATTCAAGGCACGCGCCGCGAAGGTCAAGCTCGGGCCC
GGCCTTGAAAAAGACACCACGATGGGCCCCCTGGTGAGCGCCGAGCACCGCCAACGCGTCCTCTCGTACGTGGAGGCCGG
CAAGGCCGAGGGCGGCGAGCTCCTCTTGGGCGGCACCCCCCGCGACCCCGGGTACTTCCTCGAGCCCACCCTCTTCCTCG
CAACCCGCACGGACCACAAGATCGTGCAGGAGGAGATCTTCGGTCCGGTCGCGGCGATCATCCCGTTTGAGGACGAGGAG
GAGGCCGTCCGGATCGCGAACGATACCCGTTACGGCCTCGCCGGGGGGGTCTGGACACGCGACGTGGCCCGCGCGCACCG
GGTCGCGAAACAGATCCGCACCGGCACAATCTGGGTCAACAGCTACAACCTGTTCGACCCGGCCTCGCCGTTCGGGGGGT
ACAAGGAGTCCGGGTTCGGCCGCGAGATGGGTGAGGAAGCCCTCGAGCTCTACACCGAAGTTAAGTCGGTGTGGGTGAAC
CTGCGCTAG

Protein sequence :
MLNETKAFLDRPKKLYIGGEWVDGEGTFPTHNPATGEVLAEVPYGGQAAVHQAVEAARAAFPGWSQLPPLERSRWLNRIA
DAIEAHADELAEIETLDNGKPIRESRRGDIPLAAMHFRYYAGLAPTVGGRTVPVSAPGVFNYTLREPVGVVGAIVPWNFP
LLIATWKLAPALAAGCTVVLKPAEETPLTALRLAEILEEIGFPKGVVNVVTGDGQTGAKLVQHPGVDKITFTGSTEVGKI
IMREAADRIARVSLELGGKSANIVFEDADLDAAVKGAGIGIFYNQGQLCTAGSRILVQKSVLEPFLERFKARAAKVKLGP
GLEKDTTMGPLVSAEHRQRVLSYVEAGKAEGGELLLGGTPRDPGYFLEPTLFLATRTDHKIVQEEIFGPVAAIIPFEDEE
EAVRIANDTRYGLAGGVWTRDVARAHRVAKQIRTGTIWVNSYNLFDPASPFGGYKESGFGREMGEEALELYTEVKSVWVN
LR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 8e-89 47
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 2e-91 47
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 2e-91 47
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 2e-91 47
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-91 47
hpaE AAO17179.1 HpaE Not tested tcd island Protein 2e-79 44
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 7e-73 44
orf17 AAO17183.1 Orf17 Not tested tcd island Protein 1e-68 43
unnamed AAK01506.1 putative aldehyde dehydrogenase Not tested PAGI-1 Protein 1e-78 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Marky_1279 YP_004368129.1 betaine-aldehyde dehydrogenase VFG0082 Protein 4e-89 47