Gene Information

Name : pyk (HMPREF9137_0096)
Accession : YP_004327844.1
Strain : Prevotella denticola F0289
Genome accession: NC_015311
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 106166 - 107638 bp
Length : 1473 bp
Strand : -
Note : identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064

DNA sequence :
ATGAAACAGACAAAGATAGTATGTTCAATCAGCGACCGGCGTTGCGATGTCGATTTCCTGAAGAAGCTGTTCTTCTCGGG
CATGAACGTCGTACGCATGAACACGGCTCACGCCACGCAGGACGGGATACGTGAAATCATCCGCAACACACGGGCGGTAT
CACCGCATCTGGCACTGCTGATCGATACAAAGGGACCGGAGGTGAGGACGACGGGTGTGGAAAGTCCTGTCCACTACAAG
GCAGGCGACATGGTAAAGATCTTCGGTCGTCCGGAGGTCGATTCGTCCAGGGACATCATCAATGTTTCCTATCCGGACTT
CTCGCGCGACGTGAAGGTGGGCGACCACGTCCTCTTCGATGACGGCGCGTTGGACATGGAAATCGTCGAGAGCGCCGGTC
CTATGCTGGTGGCACAGGTAAAGAATGAGGGCGACCTGGGGGCGCACAAGAGTGTGAATGTGCCGGGAGAGCATATCGAG
TTGCCGGCACTGACCGAGAAGGACAGGTGCAACATCCTGCTGGCGATAGAGGAAGACATTGACTTCATTGCCCACTCTTT
CGTCCGTTCCGCAGCTGATGTGCTGGAGGTACAGAAGATCCTCGATGAGCACAACTCGGACATCAAGATTATCTCCAAGA
TAGAAAACCAGGAGGGTGTCGACAACATCGACGAGATCATCGATGCCTCGTACGGTATCATGATTGCGCGCGGCGACCTG
GGCATTGAAGTGCCGATAGAACTGATTCCCGGCATACAGCGCAGTATTATCAACAAGTGTATTCTGAAGAAGAAACCGGT
CATCGTGGCTACGCAGATGCTCCATACGATGATCTGCAATCCCCGTCCTACCCGTGCCGAGGTGACTGATATCGCCAATG
CCATCTACAGCCACACCGACGCGCTGATGCTGAGTGGCGAGACGGCCAGCGGCAGGTATCCGGTTGAGGCTGTCCAGACG
ATGGCGCGTATCGCCGAGGCGGCAGAGCAGGATGCCCACAAACGCGGACACATTACTGTTCCCATGACGAACCCTAACGA
CCAGCGCGAGTTCCTGTCGCGCAGCGCCATTGAGGCTACGGAACAGCTGGGTGTCAAGGGAATCATCACCGACAGCGAGA
CAGGACAGACGGCCCGCAATCTTGCCGCTTTCCGTGGACCGAACCCTGTTCTGGCCATCTGTTACAAGGAAAAGGTGCAA
CGTTGGCTGAACATGAGTTACGGTGTCATAGCTGTCTACCAGCAGCAGCATAAGTCGAACGAAGAGATGTTTACTGCCGC
CTTGCGTATGCTCCGCCAGAAGGGGTACATCGACCTGGACGACAAGATTGCCTATCTGTCCGGATCGTTCGGCAACGGCG
GCGGTACGACTTTCCTTGAAATCAACAAGGTGAGCGAAGTATTCGACCGCAGTTACCGTTTCCACCTCCCGAAGGAGCAG
GACTGTATGGAAGTGACGGTTGAAGCAAAGTGA

Protein sequence :
MKQTKIVCSISDRRCDVDFLKKLFFSGMNVVRMNTAHATQDGIREIIRNTRAVSPHLALLIDTKGPEVRTTGVESPVHYK
AGDMVKIFGRPEVDSSRDIINVSYPDFSRDVKVGDHVLFDDGALDMEIVESAGPMLVAQVKNEGDLGAHKSVNVPGEHIE
LPALTEKDRCNILLAIEEDIDFIAHSFVRSAADVLEVQKILDEHNSDIKIISKIENQEGVDNIDEIIDASYGIMIARGDL
GIEVPIELIPGIQRSIINKCILKKKPVIVATQMLHTMICNPRPTRAEVTDIANAIYSHTDALMLSGETASGRYPVEAVQT
MARIAEAAEQDAHKRGHITVPMTNPNDQREFLSRSAIEATEQLGVKGIITDSETGQTARNLAAFRGPNPVLAICYKEKVQ
RWLNMSYGVIAVYQQQHKSNEEMFTAALRMLRQKGYIDLDDKIAYLSGSFGNGGGTTFLEINKVSEVFDRSYRFHLPKEQ
DCMEVTVEAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 2e-71 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-70 42
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 3e-71 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 2e-71 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_004327844.1 pyruvate kinase VFG0479 Protein 8e-72 42