Gene Information

Name : clpC (HMPREF9137_2409)
Accession : YP_004330050.1
Strain : Prevotella denticola F0289
Genome accession: NC_015311
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2817451 - 2820024 bp
Length : 2574 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGATGAATCAATTTTCCCCAAAGGTTTCGGAAATTCTTTCATTCAGCAGAGAGGAGGCGGAGCGGCTGACAAGCAGGTC
AGTGACTCCCGAGCATATCATGCTTGCCCTCTTGAGAGAGAAAACGGGACCTGTATGGGAACTGTTCAACCAATGGAAAG
TAGATATTGACAGTCTTAAGAAAGAGATAGAAAAGAAAATACGGGAACAGACTACAGACACTGCTGTGCCTGTACCCGAT
ATGCTGTTGAACGAACAGGCCAATAACATCTTGAAATTGGCTGTGCTGGAGGCTCGGCTGCAGCATGCCCAGACGGTAGA
CACCCCCCATCTCCTCCTTGCCATCCTGCACGATTCGTCGGACAATGGAGCGAAAAAGGTACTGGAAGACAGTGGAATCA
ATTACAACAACACTGTTTCCATGTTACAGCAATGCACGAGCCAGACAAAGAACGGCATCGGCATGGCAGACGAAGACGAA
ATGGATGAGGACATGGTTTCTTCATCGCCTTCGTCCGGAAGCGGGAGTACCATGACGACACAGGCTTCCCGTACAAAGTC
CAAGACCCCGGTAATCGACAGTTTCGGCACCGATTTGACCGTGGCTGCTGCTGAAGGCAAACTTGATCCGGTCGTAGGCA
GAGAAAAGGAAATCATGCGTGTCTGCGAAATTCTTGGCCGCAGGAAGAAGAACAACCCTATTCTGATCGGTGAACCAGGG
GTCGGGAAGAGTGCAATTGTGGAGGGGCTGGCTCAGCTTATCGTAAAGCATCTCACCTCTCCTATCCTCTTCGACAAGCG
CGTTATTACACTTGACCTGACGGCAGTTGTCGCCGGAACGAAATACCGCGGACAGTTTGAAGAGCGTATCCGTGCATTGA
TCAAAGAGATAGAGCAGAATCCTGACATTATCATCTTCATCGATGAAATCCATACATTGATCGGTGCCGGGTCCTCTCCG
GGGTCAATGGATGCTGCCAACATCCTCAAACCAGCTTTGGCAAGGGGGACAATACAGTGTATCGGTGCTACGACTCTGGA
CGAATACCGCAATTCCATAGAGAAGGACGGGGCTTTGGAACGCCGGTTCCAAAAGGTGCAGGTCGAACCGACGACAGTTG
ACAAGACCCTCCAGATTCTCGAGAATATAAAGGACCGCTATGAAGCCCACCATCATGTTGTCTACACAGATGATGCGCTG
AAAGCCTGTGTAAAGTATGCTGACAGATACATCACAGACAGGTTCTTTCCCGATAAGGCAATCGATATAATCGACGAAGC
AGGTTCACGTGTACATTTGCAGCATGTGAAGATTCCACAGGCAATTCTGGATATTCAGAAGGAGATTGAGACGACGCAGG
AGAAGAAGCAGGCTGCGGTGAAGAACCAGAACTTTGAACTGGCCGCCAGCTTCCGTGACAGACAGACGGAGCTTGAGCAG
ACCCTGAAGAATGAACAGGAGAAATGGCAGAAAGGAGATGCTGACGAAAAGGTTGAAATCAGTGAGGAGGACATTGCCGG
TGTTGTCTCCATGATGACAGGTGTCCCGGTACAGCGTATGCAGGAAGCAGAGGGAGTCCGCTTGAAGAACATGGATGCCG
AGCTGAAGAGGGTTGTCATTGCCCAGGATGCTGCCATTGACAAGATGGTGAAAGCCATCCAGCGTAACCGTGTGGGATTG
AAAGACCCTAACCACCCGATCGGCGCTTTCATGTTTCTGGGTCCTACTGGTGTCGGAAAGACTTATCTTGCCAAACGACT
GGCTGAAATGATGTTCGGTTCTTCGGATGCCCTGATCCGCATAGATATGAGTGAGTATACCGAGAGTTTCAACACTTCCC
GTCTTGTCGGAGCACCTCCGGGCTATGTCGGCTATGAAGAAGGCGGACAGCTGACGGAGAAAGTACGTCACCATCCCTAC
TCCATTGTTCTGCTGGACGAAATAGAGAAAGCACACGGCAATGTATTCAATATGCTTCTGCAGGTTCTTGATGAAGGCAG
ACTGACAGATGGAAACGGCCGGCTGATAGATTTCCGCAATACGGTCATCATCATGACCTCAAATGCCGGAACACGACAGT
TGAAGGAGTTCGGACAGGGTATCGGCTTCAAGGCAACAGGCCTGAACGGTCTTTCGCAGAGTGAAGGCGACAAGCAGCGT
GCTCGTTCCATCATCCAGAAGAGCCTGAGCAAACAGTTTGCTCCCGAGTTTCTGAATCGTCTGGACGAAATCGTCACTTT
CGATCAATTGGATCTCGACGCGATAAAGAAAATTATCAACATTGAGCTGAAAGGCCTGTTCAGACGTGTGCATGAACTGG
GCTATAAGATGGAGATAACAGATGAGGCCAAAGAGTTTGTAGCGATCAAGGGATACGATGTCCAGTTCGGTGCCCGGCCG
TTGAAGCGAGCCATCCAGAACTATATCGAGGATGGATTATGTGAGCTGATTCTCTCGGGCAACATCAAGACCGCCGACAC
CATCGTCATATCCAAAGAGAAAGACCGTAACAGGCTGACGTTTGACACTGTCTCGCAATCTGAAGAACAAGGCCTTCATC
ATATTGCAGAGTAA

Protein sequence :
MMNQFSPKVSEILSFSREEAERLTSRSVTPEHIMLALLREKTGPVWELFNQWKVDIDSLKKEIEKKIREQTTDTAVPVPD
MLLNEQANNILKLAVLEARLQHAQTVDTPHLLLAILHDSSDNGAKKVLEDSGINYNNTVSMLQQCTSQTKNGIGMADEDE
MDEDMVSSSPSSGSGSTMTTQASRTKSKTPVIDSFGTDLTVAAAEGKLDPVVGREKEIMRVCEILGRRKKNNPILIGEPG
VGKSAIVEGLAQLIVKHLTSPILFDKRVITLDLTAVVAGTKYRGQFEERIRALIKEIEQNPDIIIFIDEIHTLIGAGSSP
GSMDAANILKPALARGTIQCIGATTLDEYRNSIEKDGALERRFQKVQVEPTTVDKTLQILENIKDRYEAHHHVVYTDDAL
KACVKYADRYITDRFFPDKAIDIIDEAGSRVHLQHVKIPQAILDIQKEIETTQEKKQAAVKNQNFELAASFRDRQTELEQ
TLKNEQEKWQKGDADEKVEISEEDIAGVVSMMTGVPVQRMQEAEGVRLKNMDAELKRVVIAQDAAIDKMVKAIQRNRVGL
KDPNHPIGAFMFLGPTGVGKTYLAKRLAEMMFGSSDALIRIDMSEYTESFNTSRLVGAPPGYVGYEEGGQLTEKVRHHPY
SIVLLDEIEKAHGNVFNMLLQVLDEGRLTDGNGRLIDFRNTVIIMTSNAGTRQLKEFGQGIGFKATGLNGLSQSEGDKQR
ARSIIQKSLSKQFAPEFLNRLDEIVTFDQLDLDAIKKIINIELKGLFRRVHELGYKMEITDEAKEFVAIKGYDVQFGARP
LKRAIQNYIEDGLCELILSGNIKTADTIVISKEKDRNRLTFDTVSQSEEQGLHHIAE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 4e-173 45

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_004330050.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 2e-146 49
clpC YP_004330050.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 0.0 48