Gene Information

Name : clpC_1 (HMPREF9243_0430)
Accession : YP_004320779.1
Strain : Aerococcus urinae ACS-120-V-Col10a
Genome accession: NC_015278
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 427826 - 430345 bp
Length : 2520 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGAAAGACATCTATACTGAAAAAGCCAAGACCGCGATTGGATTTGCCAAAGAAGAAGCTGAATACTTCCGTCATCCAGC
CATTGGTAGCGAGCATATGCTTTTGGGCTTATACCGCGAAAGTGAAGGTGTTGCTCATGCCGTTTTAAGCGATTACTTGC
CAAGTTATGAGAGTCTTCGTGAAGAGATTGAATTTGTGACCGGCTACGGGACCAGCGATTCAGCCAAGAGCCAGGAAGAC
TATGTGCAGTTTTCCCCACGCATGCAAGACGTCTTGAACCAAGCCAAAGACTTGGCCAAGTCTATGCAGGCTTCCTTAAT
TGGTACCGAGCACTTATTACTCGCCCTCATCAATGAGGAAACCCTGGCCAACCGCCTGCTGAAAAATCTCGATATAGATG
TTAATCGTTTGCGTAGTGATGTCTATCAGATGCTGGGACAAAAAGAACCAGTTAGGAACCGGACCAAAAAGCCGCTGGGT
AAGCAAAGCAAAAGCAAGACCCCAACCTTGGACAGTATTGCTAAGGACCTGACCCAAGCCGCTAAGGACGGCAAGCTGGA
CCCTGTGATCGGTCGCCAGCAAGAAATGCGTCGGCTCATGCAGGTCTTAAGCCGTCGGACCAAGAATAACCCGGTCCTGG
TTGGTGAACCTGGGGTCGGTAAGACCGCTATTGTCGAAGCCTTAGCCATCCAAATGAGCCAACAGCAAGTCCCAGAAAAC
ATGCTGGATAAACGACTCATGGTCTTAGATATCGGCTCTTTAGTTGCTGGGACTAAGTACCGCGGTGAATTTGAAGACCG
CATGAAGCATTTAATTGAAGAAATTGAAGACCAAGGTAATATTATTCTCTTTATCGATGAAATTCATACCATTATAGGGG
CTGGGGGAGCTGAAGGAGCCATTGATGCCTCAAACCTCCTAAAACCTGCCCTCAGCCGGGGACAAGTTCAACTGATCGGG
GCTACAACCCTCAACGAATATCAAAAATACATCGAAAAAGATGCTGCCTTGGAAAGACGTTTTGCTAAGATTTTAGTTGA
AGAACCCACATTAGAGGAGACTGAAGAAATCCTTAAAGGGATCCGGCCTGCCTATGAAAAACATCACCAAGTCGCTATTC
CTGATGAGAGCATTACCACCTGTGTGCGTTTAAGCTCCCGTTACTTATCGGACCGCTTCTTACCAGATAAGGCCATTGAT
GTTATGGACGAAGCGGCGGCTACTAAGCGGCTGGACAATCCAGTAGCCAATAGTGGTCGCCGGAAAAAATTCCAAATCGA
ACAGGAATTGAAGCGCCTCAACCAAGAAAAAGAATACCATGTCCGTAACCAGGCCTTTCAAAAGGCGGCCGCGGTCCATG
CCCAACAAGCGAACCTAGTCAGAGAACTTAGTCGCTTGGAAACAGACGAAGGCGACCAGGACAATCAAGACAGCTACGAC
TTAAGTTTGACCAGTCAAGACGTGCAAAACTTGATTCATTCTTGGACCGGTATTCCAGTTCAAGAATTGAGTCAAAGTGA
TAATGAACGCTTGATCCACTTAGAAGACCGCCTCCATGACCGGGTCAAGGGACAAGATGAAGCGGTCAATGCGGTAGCCC
GGGCCATTAAACGGTCGCGCAGTGGTTTGGGACAAAGAAACCGGCCCATCGGTTCCTTTATGTTCCTAGGGCCAACGGGA
GTTGGGAAAACCGAATTGGCCAAGACCTTTGCCGAAACCCTTTTTGGTTCGGAAGAGGCTCTGATTCGTTTAGATATGTC
TGAATACATGGAGAAATATTCTTCCAGCCGGATGATAGGGTCTGCACCCGGTTATGTTGGCTATGAAGAAGGGGGTCAAC
TGACCGAGAAAATTCGTCAACACCCCTATTCCATTGTCCTCTTCGATGAAATTGAAAAGGCCCATCCTGATGTCTTTGAC
CTCTTACTTCAAGTCCTTGATGACGGTTATATCACCGATAGTAAGGGTCGGATGGTGGACTTTAGAAATACGGTAGTCAT
CATGACCTCTAATATTGGGGCCACTGAATTACGGGATGAAAAACTGGTCGGCTTTGGCCAAGATAACCAACAAAAAGACT
ATCAAAGCATGAAGAAACGGATAATGGAAGCCTTGAAGAAGACCTTTAGACCGGAGTTTCTTAACCGGGTGGATGAAGTG
ATTGTCTTCCACGCCCTAAGTCAAGACAACTTGAAGGATATTGTCCGCAAATTTACCGACCAAATTAGCCAACAAGTGGA
AGAACAAGGCTTGACCTTGCGCTTTACCAATGGGGCCATTAAGCAATTGGCTAAGGACGGTTATGACCCAGAAATGGGTG
CCCGGCCCGTTCGCCGCCTCATCCAACGGCAAATTGAAGATGCTCTGAGTGACCTCTTGATTGAAGGAAAGGTCCAAGCT
GGGGACAGCCTTCAAGTAGGCAGCCGCCAAGGCACTTTCTACATCCGTACTAAACATGGCGACGGCAGTGAAAGCCAGGC
TGATCTGGAAAAAGTGGAGGAAAGCCTGTCCCTAGGATAG

Protein sequence :
MKDIYTEKAKTAIGFAKEEAEYFRHPAIGSEHMLLGLYRESEGVAHAVLSDYLPSYESLREEIEFVTGYGTSDSAKSQED
YVQFSPRMQDVLNQAKDLAKSMQASLIGTEHLLLALINEETLANRLLKNLDIDVNRLRSDVYQMLGQKEPVRNRTKKPLG
KQSKSKTPTLDSIAKDLTQAAKDGKLDPVIGRQQEMRRLMQVLSRRTKNNPVLVGEPGVGKTAIVEALAIQMSQQQVPEN
MLDKRLMVLDIGSLVAGTKYRGEFEDRMKHLIEEIEDQGNIILFIDEIHTIIGAGGAEGAIDASNLLKPALSRGQVQLIG
ATTLNEYQKYIEKDAALERRFAKILVEEPTLEETEEILKGIRPAYEKHHQVAIPDESITTCVRLSSRYLSDRFLPDKAID
VMDEAAATKRLDNPVANSGRRKKFQIEQELKRLNQEKEYHVRNQAFQKAAAVHAQQANLVRELSRLETDEGDQDNQDSYD
LSLTSQDVQNLIHSWTGIPVQELSQSDNERLIHLEDRLHDRVKGQDEAVNAVARAIKRSRSGLGQRNRPIGSFMFLGPTG
VGKTELAKTFAETLFGSEEALIRLDMSEYMEKYSSSRMIGSAPGYVGYEEGGQLTEKIRQHPYSIVLFDEIEKAHPDVFD
LLLQVLDDGYITDSKGRMVDFRNTVVIMTSNIGATELRDEKLVGFGQDNQQKDYQSMKKRIMEALKKTFRPEFLNRVDEV
IVFHALSQDNLKDIVRKFTDQISQQVEEQGLTLRFTNGAIKQLAKDGYDPEMGARPVRRLIQRQIEDALSDLLIEGKVQA
GDSLQVGSRQGTFYIRTKHGDGSESQADLEKVEESLSLG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 2e-170 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC_1 YP_004320779.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 0.0 52
clpC_1 YP_004320779.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 8e-133 50