Gene Information

Name : ermC' (HMPREF9243_0168)
Accession : YP_004320562.1
Strain : Aerococcus urinae ACS-120-V-Col10a
Genome accession: NC_015278
Putative virulence/resistance : Resistance
Product : rRNA adenine N-6-methyltransferase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0030
EC number : 2.1.1.-
Position : 171645 - 172376 bp
Length : 732 bp
Strand : +
Note : identified by match to protein family HMM PF00398; match to protein family HMM PF02390

DNA sequence : 
ATGAAACAGAAAAACCCGAAAAATACGCAAAATTTCATTACATCTAAAAAGCATGTAAAGGAAATATTAAAATATACGAA
TATCAATAAACAAGATAAAATAATAGAAATTGGGTCAGGAAAAGGACATTTTACCAAGGAACTTGTGGAAATGAGTCAAC
GGGTGAATGCTATAGAGATTGATGAAGGTTTATGTCATGCCACGAAAAAAGCAGTTGAACCTTTTCAGAATATAAAAGTT
ATTCATGAGGATATTTTGAAGTTTAGCTTTCCTAAAAATACAGACTATAAAATATTTGGTAATATTCCCTACAATATTAG
TACTGATATTGTAAAAAAGATTGCTTTTGATAGTCAAGCGAAATATAGCTACCTTATTGTAGAGAGGGGATTTGCTAAAA
GGTTGCAAAATACCCAACGAGCTTTAGGTTTGCTGTTAATGGTGGAAATGGATATAAAAATTCTTAAAAAAGTGCCACGA
GCATATTTTCACCCTAAGCCTAATGTAGATTCTGTATTGATTGTACTTGAAAGGCATAAACCATTTATTTTAAAGAAGGA
CTACAAAAAGTATAGATTTTTCGTTTATAAATGGGTAAACAGGGAATATCATGTTCTTTTTACTAAAAATCAATTAAGAC
AGGTGCTGAAGCATGCGAATGTTACTGATCTTGATAAATTATCCAATGAACAATTTTTGTCTGTTTTCAATAGTTACAAA
TTATTTCAATAA

Protein sequence : 
MKQKNPKNTQNFITSKKHVKEILKYTNINKQDKIIEIGSGKGHFTKELVEMSQRVNAIEIDEGLCHATKKAVEPFQNIKV
IHEDILKFSFPKNTDYKIFGNIPYNISTDIVKKIAFDSQAKYSYLIVERGFAKRLQNTQRALGLLLMVEMDIKILKKVPR
AYFHPKPNVDSVLIVLERHKPFILKKDYKKYRFFVYKWVNREYHVLFTKNQLRQVLKHANVTDLDKLSNEQFLSVFNSYK
LFQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ermA-3 YP_190052.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 2e-95 82
unnamed BAB47663.1 rRNA adenine N-6-methyltransferase Not tested Type-III SCCmec Protein 3e-95 82
unnamed BAC53825.1 rRNA adenine N-6-methyltransferase Not tested SRImec-III and SCCmec-III region Protein 3e-95 82
ermA BAC57474.1 rRNA methylase Not tested Type-IIIinv SCCmec Protein 1e-95 82
ermA BAA82205.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 1e-95 82
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 Not tested Type-II SCCmec Protein 2e-95 82
ermA NP_370576.1 rRNA methylase Not tested Type-II SCCmec Protein 2e-95 82
ermA NP_373288.1 rRNA methylase Not tested Type-II SCCmec Protein 2e-95 82
ermC NP_273130.1 rRNA adenine N-6-methyltransferase Not tested IHT-A Protein 2e-63 60

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002745.1122822.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002745.1124324.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002745.1125313.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_009782.5559087.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002758.1121630.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002952.2859615.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002745.1123579.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002745.1124852.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_009782.5559229.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002758.1120012.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_002952.2859614.p0 Protein 7e-96 82
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase AJ313523.1.orf0.gene Protein 4e-82 71
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase M64090.gene.p01 Protein 3e-65 62
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_010686.6295746.p0 Protein 8e-64 60
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase V01278.gene.p01 Protein 9e-64 60
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_010685.6295744.p0 Protein 8e-64 60
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_007209.3523503.p0 Protein 9e-64 59
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase NC_007792.3912746.p0 Protein 3e-63 59
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase M15332.gene.p01 Protein 4e-63 56
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase AM180355.1.gene2254. Protein 3e-50 49
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase AM410044.gene14.p01 Protein 5e-51 49
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase AM180355.1.gene2259. Protein 3e-50 49
ermC' YP_004320562.1 rRNA adenine N-6-methyltransferase AM903082.gene3.p01 Protein 5e-51 49