Gene Information

Name : clpC_2 (HMPREF9243_1443)
Accession : YP_004321614.1
Strain : Aerococcus urinae ACS-120-V-Col10a
Genome accession: NC_015278
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 1446247 - 1448436 bp
Length : 2190 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
TTGAAATGCCAACGTTGTAACCAACGCGAAGCTGCCATTCACATGTATGCGAATATTAACGGTCAAAGGCAGGCCATTAA
CCTTTGCCAACCTTGTTATGCAGAGATAATTCGCAACCAATCTCAAGCTGGGAAAAGCAATAATGACAATAATTCATGGG
GAAACCTCTATGAGCTTCTTAGACAAATGCAAGATAAAGGGCCCCATAATGCTAACGGCCAAGAGCCTCCCCACCATCCT
AATGATGGCCAGGGAAATAGCTTGTTGGCTAATTATGGAACCAACATGACTGAATTGGCTCGCCAAGGCAAGTACGACCC
GGTAATTGGCCGTGACCAAGAAATAAATCGGGTAATCGAAATTCTCAACCGTCGAACCAAAAATAATCCTGTCCTCATCG
GAGAAGCTGGTGTAGGTAAGACGGCAGTTGTGGAAGGTTTAGCCCAAAAAATAGTGGCTAAAGAAGTTCCTGAAAAGCTA
CAAAATAAGGAAGTTATTAGTTTAGATGTGGCTTCCTTAGTCCAAGGTACTGGGGTTCGGGGCCAATTTGAAGAAAAAAT
GCAAGCCCTGATTAAAGAAGTCTCTTCCAATCAATCAATCATTCTATTTATTGACGAAATCCATGAAATTGTGGGGGCAG
GAACAGCCGATAATTCATCAATGGATGCTGGCAACATCTTAAAACCTGCCTTGGCCCGGGGCGAAATGCAATTAGTTGGG
GCAACAACCCTAAATGAATTCCGTCGTATCGAAAAAGATGGCGCACTGGCTCGCCGCTTACAACCGGTTCAAGTGGATGA
GCCTTCGGTGGAAGAAGCCATCACTATTATCAAGGGTCTAGCCGACCAATACCAAAAATTCCACCATGTTCACTTTACTG
ACCAAGCCTTAGAAGCAACGGTTACCCTGTCTAATCGTTATATCCAAGACCGGCAATTACCTGATAAGGCCATCGACCTA
CTTGATGAAGCGGGCTCTAAGAAAAACTTAACCATTCCCTTCTTGGATAAGGAGGCCTTAGAAGATCAGATTCAAGAATT
AGAAAAATTAAAGGAAATGGCTACCGATGCGGAAGACTATGAGAAGGCGGCCTATTACCGCGACCAATTAAAGAAATATA
AGGATATGGCCGCTAATAATGAAGCTGTTGTTGAACAAGTCCCAACGATCACCGTCGAAGACATCGAAGAATTAGTGGAA
GCTAAAACCGGTATCCCCGTTGGCCAGTTACAAGACCAAGAACAAAGCAATTTATTGCAACTTGAGGATGAACTCAAGGA
GACAATTATCGGCCAAGATCCTGCTGTCGAAAAAGTATCAGCAGCAATCCGGCGTAACCGTGTGGGCTTCCACCCAGGTA
ATAAACCCATTGCTTCCTTCCTATTTGTGGGGCCAACGGGTGTCGGCAAGACAGAATTAGCCCGTCAGCTTGCTAAGCAA
CTCTTTGGTAGTGAAGAAGCAATGATCCGCTTTGACATGTCTGAATACATGGAAAAACACAGTGTCTCTAAGATGATCGG
TTCACCACCCGGCTATGTCGGCTATGACGAAGCTGGCCAATTAACCGAGCAAGTCAGACGGCAACCTTATTCCCTCATTC
TCTTAGATGAAGTGGAAAAAGCCCATCCTGATGTTCTCAACCTCTTCCTACAAATCATGGAAGACGGTCGACTTACTGAT
GCACAAGGTCGGACGGTTTCCTTTAAAGATACCCTTATCATCATGACTTCCAATGCCGGAACGGGTAACGTTGAAGCTAG
CGTCGGTTTTGCCGCTAGTCAACAAGGGAAAAACCAATCTGTCTTGGACCAATTGGATAATTACTTTAAACCTGAATTCA
TGAACCGCTTCGACGGCATCATCGAATTCCAACCGCTGACCAAGGAAGAATTGATTCAAATTGTCGACCACATGCTCACC
AGCATGAACAAATTACTCAAGGGACAAAAAATCTGCATTGCCATTGACGACCAAGTGAAAGAAGCTATTGTTGAACTAGG
CTATGACCCCAAACTGGGTGCCCGCCCATTAAGACGGGTCATCCAAGAACAAATTGAAAACCAAGTCGCGGACCTATACT
TAAAGGATCCAAGCATTAGCTATGTCCACTTTAGCGTGGATGATTCTGGCAACATTGTTGTTAATGAGAGTGAAAATAGT
CAGGCCATTGAAGAAGCAGACGTCGATTGA

Protein sequence :
MKCQRCNQREAAIHMYANINGQRQAINLCQPCYAEIIRNQSQAGKSNNDNNSWGNLYELLRQMQDKGPHNANGQEPPHHP
NDGQGNSLLANYGTNMTELARQGKYDPVIGRDQEINRVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQKIVAKEVPEKL
QNKEVISLDVASLVQGTGVRGQFEEKMQALIKEVSSNQSIILFIDEIHEIVGAGTADNSSMDAGNILKPALARGEMQLVG
ATTLNEFRRIEKDGALARRLQPVQVDEPSVEEAITIIKGLADQYQKFHHVHFTDQALEATVTLSNRYIQDRQLPDKAIDL
LDEAGSKKNLTIPFLDKEALEDQIQELEKLKEMATDAEDYEKAAYYRDQLKKYKDMAANNEAVVEQVPTITVEDIEELVE
AKTGIPVGQLQDQEQSNLLQLEDELKETIIGQDPAVEKVSAAIRRNRVGFHPGNKPIASFLFVGPTGVGKTELARQLAKQ
LFGSEEAMIRFDMSEYMEKHSVSKMIGSPPGYVGYDEAGQLTEQVRRQPYSLILLDEVEKAHPDVLNLFLQIMEDGRLTD
AQGRTVSFKDTLIIMTSNAGTGNVEASVGFAASQQGKNQSVLDQLDNYFKPEFMNRFDGIIEFQPLTKEELIQIVDHMLT
SMNKLLKGQKICIAIDDQVKEAIVELGYDPKLGARPLRRVIQEQIENQVADLYLKDPSISYVHFSVDDSGNIVVNESENS
QAIEEADVD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 1e-149 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC_2 YP_004321614.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 0.0 56
clpC_2 YP_004321614.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 1e-154 49