Gene Information

Name : pyk (HMPREF9243_1372)
Accession : YP_004321549.1
Strain : Aerococcus urinae ACS-120-V-Col10a
Genome accession: NC_015278
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1373585 - 1375372 bp
Length : 1788 bp
Strand : -
Note : identified by match to protein family HMM PF00224; match to protein family HMM PF00391; match to protein family HMM PF02887; match to protein family HMM TIGR01064

DNA sequence :
ATGCCATTTGATATGAAATTATTAAAGAAAACCAAAGTTGTATGTACGATTGGACCTGCTTCAGAAGATCCAGAAACCCT
AGTCGAACTGGCTAAAGCAGGTATGGACGTTGCCCGGATGAACTTTTCTCACGGTGACCACGATGAACACTTAGCCCGCA
TCAAAGCAATTCGCCAAGTGGAACGTGAAGCTGGAAAACGGATTGCGGTTATGCTAGATACCAAGGGTCCTGAAATTCGT
ACCCATAACATGAAGGACCATGCTCCGGTTTTCTTAGAAAAGGGTAAAACCGTTAAAATTTCTATGACTGAAGTTGAAGG
AACCCAAGACATGATTTCAGTCACTTATCCTCAATTAATTAATGATGTTCATGTTGATTCTCATATTCTCATTGATGATG
GTTTAGTTGATTTACGTGTTACTGACATTGACTTTGATAAGGGAATTGTTACCACTGTTGTGGAAAATAGTGGTTTAATC
AAAGACAAGAAGGGGGTTAATATTCCTGGCGTTTCCGTATCCCTACCTGGTATCACTGAAAAAGATGAAGCCGACATTCG
TTTTGGCCTAGAAAATGGAATTGACATTATCGCTGCTTCCTTTGTTCGTAAGCCAGAAGATGTTTTAGAGATTCGCGAAA
TTTTAGAAGAAACCGGGAACGAAACAGTTCAAATTATCCCTAAAATTGAAACCCAAGAAGGGGTAGATAATATTGACGGG
ATTTTGCAAGTTTCTGATGGTTTAATGGTTGCCCGTGGTGACCTAGGGGTAGAAATACCAACTGAGATGGTGCCAGTTGT
TCAAAAAGAATTAATCCGTAAGTGTAATGCGGCTGGTAAACCAGTTATTACTGCTACCCAAATGTTAGATTCTATGCAAC
GTAACCCACGTCCAACCCGGGCTGAAGCTTCTGACGTTGCTAATGCCATTCTAGACGGTACCGATGCGATTATGTTATCC
GGTGAAACAGCTGCTGGTGACTACCCACTTGAAGCCGTTAAGACCATGACCCGTATCGCTATGACTACTGAACGTGAAAG
CGAATTACGTGGTCAAGCCCAACAAGCCCTTAAAGAATATCAAAACAGTGATGTTTCTGAAGCCATTGCCCAATCTGTTG
CCCATACAGCTCGCAATTTGAATATTCAAACCATCGTTGCTGCAACAAATTCAGGTCATACTGCTCGTTTAATTTCTAAG
TACCGTCCTAATGCCATGATCTTAGCGCTTACCTTCTCTGAAAGTCGTGCGCATAAGTTATTACTTAGCCGTGGTGTGGT
TCCAATGGTCATTGAAAAACCGGCATCTACCGATGAAATGACCTTACTTGCCACCCAAATTGCTAAAGAAGAAGACTACG
CTAAAGATGGCGACCTTATCCTTATTACAGCTGGTGTACCGGTTGGGGAAACAGGGACCACCAACTTGATGAAGATTCAA
ATGATTGGTGAACGTTTGATTGAAGCTCAAGGGCTAGGAAATCAATCAGTCATTGGACACGTGGTTAAAGCTCAAAGCCC
AGAAGAAGCCATTGAAAAAGCTAACCATGATAACATCTTAGTGGTTTCTACAACTGATGAACGCTATAATGAAGCCATTA
AGAAGGCAGGGGCTGTTATTGTAGAAAACGCCACACTAACTAGCCATGCTGCTGTAATGAGTGTCAATACCGGGACTCCG
GTTATCGTTAATGCTAAAGATGCGACGAACATTCTTGAAGAAGGCCAATTGATTACCTTGGATGCACGTCGCGGTATGGT
TTATGATGGTGCCACGACGACTATCTAA

Protein sequence :
MPFDMKLLKKTKVVCTIGPASEDPETLVELAKAGMDVARMNFSHGDHDEHLARIKAIRQVEREAGKRIAVMLDTKGPEIR
THNMKDHAPVFLEKGKTVKISMTEVEGTQDMISVTYPQLINDVHVDSHILIDDGLVDLRVTDIDFDKGIVTTVVENSGLI
KDKKGVNIPGVSVSLPGITEKDEADIRFGLENGIDIIAASFVRKPEDVLEIREILEETGNETVQIIPKIETQEGVDNIDG
ILQVSDGLMVARGDLGVEIPTEMVPVVQKELIRKCNAAGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAIMLS
GETAAGDYPLEAVKTMTRIAMTTERESELRGQAQQALKEYQNSDVSEAIAQSVAHTARNLNIQTIVAATNSGHTARLISK
YRPNAMILALTFSESRAHKLLLSRGVVPMVIEKPASTDEMTLLATQIAKEEDYAKDGDLILITAGVPVGETGTTNLMKIQ
MIGERLIEAQGLGNQSVIGHVVKAQSPEEAIEKANHDNILVVSTTDERYNEAIKKAGAVIVENATLTSHAAVMSVNTGTP
VIVNAKDATNILEEGQLITLDARRGMVYDGATTTI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 4e-100 49
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 4e-100 49
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 4e-100 49
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 7e-100 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_004321549.1 pyruvate kinase VFG0479 Protein 2e-100 49