Gene Information

Name : NAL212_0101 (NAL212_0101)
Accession : YP_004293226.1
Strain :
Genome accession: NC_015221
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 3500 - 5185 bp
Length : 1686 bp
Strand : +
Note : TIGRFAM: Mercury reductase, MerA; KEGG: see:SNSL254_p_0165 putative mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; Heavy metal transport/detoxification pr

DNA sequence :
ATGACTAATCTAAGAATCACCGGCATGACCTGCGACTCGTGCGCGGCGCACGTCAAGGAAGCGCTGGAAAAGGTCCCCGG
CGTGCAGTCGGCGCTGGTGTCCTATCCGAAGGGCACAGCGCAACTCACCACCCTGCCGGGCACGTTACCGGATGCGCTGA
CTGCCGCCGTGGCCGGACTGGGCTACAAAGCAACGCTCGCCGATGTTCCACCGACGGACAACCGCAGCGGACTGCTCGAC
AATGTGCGCGGCTGGATGGGGGGCGCTGATAAACGTAGCGACGGCGAACACCCGTTGCAAGTAGCCGTCATTGGCAGCGG
TGGAGCCGCGATGGCGGCAGCACTGAAAGCCGTCGAGCAAGGCGCGCACGTCACGCTGATCGAGCGCGGCACCATCGGCG
GCACCTGCGTCAATATCGGCTGCGTGCCGTCCAAGATCATGATTCGCGCCGCCCACATCGCCCATCTGCGTCGGGAAAGC
CCGTTCGATGGCGGCATGCCACCCACACCGCCGACGATCCTGCGCGAGCGGCTGCTGGCCCAGCAGCAGGCCCGTGTCGA
TGAGCTGCGTCATGCCAAGTACGAAGGCATCCTGGACGGCAATTCAGCCATCACCGTTCTGCACGGTGAAGCGCGTTTCA
AGGACAACCAGAGTCTTGCCGTCCATTTGAACGATGGCGGCGAGCGCGTGGTGGCTTTCGACCGCTGCCTGGTCGCCACG
GGTGCCAGTCCGGCCGTGCCGCCGATTCCGGGCCTGAAAGAGTCACCCTACTGGACTTCGACCGAGGCCCTGGTCAGCGA
CACCATTCCCGAACGCCTGGCCGTGATCGGCTCGTCGGTGGTGGCGCTGGAACTGGCGCAAGCCTTCGCCCGGCTGGGTA
GCCAGGTCACGATCCTGGCGCGCAGCACCTTGTTCTTTCGGGAAGACCCGGCCATCGGCGAGGCCGTCACAGCCGCTTTC
CGTGCCGAGGGCATCGAGGTGCTGGAACATACACAAGCGAGCCACGTCGCCTATGTGGAAGGGAATTTCGTGCTGACCAC
CGGGCACGGCGAAGTGCGTGCCGACAAGTTGCTGGTCGCCACCGGCCGGACACCGAACACGCGCAGCCTTCTACTCCCAG
CAGCGGGTGTTGGAGTCAATGCGCAGGGTGCCATCGTCATCGACAAGGGAATGCGCACGAGTAACCCGGACATCTACGCG
GCCGGCGACTGCACCGACCAGCCTCAGTTCGTCTATGTCGCGGCAGCGGCCGGCACCCGTGCAGCGATCAACATGACTGG
CGGAGACGCGGCCCTGGACCTGACCGCGATGCCGGCCGTGGTGTTCACCGATCCGCAAGTGGCGACCGTGGGCTACAGCG
AAGCGGAAGCGCACCATGACGGCATCGAGACCGATAGCCGGCTGCTGACGCTGGACAACGTGCCGCGTGCGCTCGCCAAT
TTCGACACACGCGGCTTCATCAAGCTGGTGGCCGATGCCGGCAGCGGGCGCTTGATCGGTGTGCAGGCGGTGGCTCCGGA
AGCGGGCGAGCTGATCCAGACGGCGGTCCTGGCTATTCGCAACCGCATGACAGTGCAGGAACTGGCCGACCAATTGTTCC
CCTACCTGACGATGGTCGAAGGGTTGAAGCTCGCGGCGCAGACCTTCAACAAGGACGTGAAGCAGCTTTCCTGCTGCGCC
GGATGA

Protein sequence :
MTNLRITGMTCDSCAAHVKEALEKVPGVQSALVSYPKGTAQLTTLPGTLPDALTAAVAGLGYKATLADVPPTDNRSGLLD
NVRGWMGGADKRSDGEHPLQVAVIGSGGAAMAAALKAVEQGAHVTLIERGTIGGTCVNIGCVPSKIMIRAAHIAHLRRES
PFDGGMPPTPPTILRERLLAQQQARVDELRHAKYEGILDGNSAITVLHGEARFKDNQSLAVHLNDGGERVVAFDRCLVAT
GASPAVPPIPGLKESPYWTSTEALVSDTIPERLAVIGSSVVALELAQAFARLGSQVTILARSTLFFREDPAIGEAVTAAF
RAEGIEVLEHTQASHVAYVEGNFVLTTGHGEVRADKLLVATGRTPNTRSLLLPAAGVGVNAQGAIVIDKGMRTSNPDIYA
AGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRLLTLDNVPRALAN
FDTRGFIKLVADAGSGRLIGVQAVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCA
G

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 0.0 92
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 0.0 92
merA ABQ57371.1 MerA Not tested SGI1 Protein 0.0 87
merA AGK07021.1 MerA Not tested SGI1 Protein 0.0 87
merA AGK07079.1 MerA Not tested SGI1 Protein 0.0 87
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 0.0 84
merA AFG30120.1 MerA Not tested PAGI-2 Protein 0.0 84
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 0.0 84
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 0.0 81
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 0.0 75
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 2e-85 42
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 1e-85 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
NAL212_0101 YP_004293226.1 mercuric reductase BAC0652 Protein 0.0 90
NAL212_0101 YP_004293226.1 mercuric reductase BAC0653 Protein 0.0 81
NAL212_0101 YP_004293226.1 mercuric reductase BAC0650 Protein 3e-177 70
NAL212_0101 YP_004293226.1 mercuric reductase BAC0651 Protein 9e-86 42
NAL212_0101 YP_004293226.1 mercuric reductase BAC0224 Protein 2e-83 41