Gene Information

Name : Dester_1148 (Dester_1148)
Accession : YP_004281844.1
Strain : Desulfurobacterium thermolithotrophum DSM 11699
Genome accession: NC_015185
Putative virulence/resistance : Virulence
Product : two component transcriptional regulator, winged helix family
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 1142767 - 1143438 bp
Length : 672 bp
Strand : +
Note : COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789: IPR001867; KEGG: tye:THEYE_A0752 DNA-binding response regulator; PFAM: Signal transduction response regulator, receiver

DNA sequence :

ATGAAAATACTTTTAGTGGAAGATGAGAAACTATTGGCAAATACTTTAAAGAAAGGTTTAGAAGAAGAAGGATATATTGT
GGATGTAGCATACGATGGAGAAGAAGGTTTTTTCTTAGGTAGATGTTATGGTTACGATGTTATTATCTTAGATGTGATGC
TTCCTAAGTTAGATGGAATGGAGCTCTTGTTAAAATTGAGAGAAGAGGGAGTTAAAACTCCCATTTTAATGCTAACAGCA
AAAGATTCTGTAGAAGATAAAGTAAAAGGTTTAGATAGTGGAGCTGACGATTATCTAACAAAACCTTTTTCTTATGATGA
ACTTCTTGCACGGATAAGAGCTCTACTTCGGAGAAAATCTGAATCCAAAACTTCATTCATCAAAATAAAAGACTTAGAAA
TCGATTTAAACAAAAAGATTGTAAAAAGAGCTGGAAATGAAATAAAACTTACAAAGAAAGAATTTAAAGCTTTAACATTA
CTTGCTTTAAATAAAAACAGAGTAATTAGTAAAGAATTTCTTATAGATAGTCTCTACTCTACAGATAGATTTGTAAGTAT
TAATGCTATAGAAGTTTTAATCAATAGATTAAGAAAGAAAATAGATAAAGACTATCCTCTAAAGCTAATACATACTATTA
AAGGATTTGGATATATGATAAAAGATGATTAA

Protein sequence :

MKILLVEDEKLLANTLKKGLEEEGYIVDVAYDGEEGFFLGRCYGYDVIILDVMLPKLDGMELLLKLREEGVKTPILMLTA
KDSVEDKVKGLDSGADDYLTKPFSYDELLARIRALLRRKSESKTSFIKIKDLEIDLNKKIVKRAGNEIKLTKKEFKALTL
LALNKNRVISKEFLIDSLYSTDRFVSINAIEVLINRLRKKIDKDYPLKLIHTIKGFGYMIKDD

• Homologs from PAI DB

Gene	GenBank Accn	Product	Virulance or Resistance	PAI or REI	Alignment Type	E-val	Identity
copR	NP_460069.2	transcriptional regulatory protein YedW	Not tested	SPI-5	Protein	5e-35	43
copR	AAC33719.1	regulatory protein CopR	Not tested	SPI-5	Protein	3e-34	43

• Homologs from CARD and BacMet (resistance genes)

Gene	GenBank Accn	Product	ID of source DB	Alignment Type	E-val	Identity
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0308	Protein	6e-34	48
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0083	Protein	9e-33	46
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_007622.3794948.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_003923.1003417.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_013450.8614146.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_002951.3238224.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_007793.3914065.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_002758.1121390.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_010079.5776364.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_002952.2859858.p0	Protein	2e-26	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0111	Protein	5e-35	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0197	Protein	7e-34	44
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0487	Protein	6e-27	43
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0125	Protein	1e-34	43
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0638	Protein	2e-32	43
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	BAC0347	Protein	9e-35	42
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	NC_002516.2.879194.p	Protein	8e-30	41

• Homologs from VFDB (virulence genes)

Gene	GenBank Accn	Product	ID of source DB	Alignment Type	E-val	Identity
Dester_1148	YP_004281844.1	two component transcriptional regulator, winged helix family	VFG0596	Protein	2e-35	43