Gene Information

Name : merA (ACMV_P1_00190)
Accession : YP_004276957.1
Strain :
Genome accession: NC_015178
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 18176 - 19816 bp
Length : 1641 bp
Strand : -
Note : -

DNA sequence : 
ATGACCTCTCTTACTCTGAGCGTGACGGGCATGACCTGCGAGCACTGCGCTCGCATAGCCGAGAAAGCCCTCAACAGCCT
TCCGGACGTCCGGGCGGATGTCAACTACGATCGCCGGACCGCGCGGATCGACGGCGCCGATGGTCTTGACCTCGCGGCGC
TGCGAGCTGCGCTTGCGCCGCATGGCTATGGGATGGAGACGCTGAACGACGACACCACGCGCGGCACGACGGCCCCGCAC
GGCGGTGGGCTGCATATCGCCATCATCGGCAGTGGCGGCGCTGCCTTTGCGGCCGCCATCCGGGCGGTTGATGCCGGCGC
CCGGGTGACCATGATCGAGCGAGGCGAGGTCATCGGCGGCACCTGCGTCAATGCTGGATGCGTGTCCTCAAAAATCACTC
TCCGGGCCGCCGAAATCCGGCATGAGCGTGGGCACCATCCGTTCGACGGTATCGCCCGCAGCGAAGAACCGGTGGACCGG
CGGGTGTTGCTTGCCCAGTTGCGCGGGCGGGTGGACGCGCTGCGTGGTGCGAAATACCAGAAGATCATCGATGACAATCC
GGGGATCACGCTGCTGCGTGGCGAAGCACGCTTCGCGGATGCGCGCACGCTCACGATCACTGAGCACACTGGAAAGGTAA
CGCGGCAGACTCCGGATCGCATCCTCATCGCGACCGGTGCCGCGCCGATGATCCCGCCGGTCCCGGGGCTCGCGGAGACC
CCGTACTGGACCTCGACTGAATCCCTGTTTGCTGACGAGCTTCCCACCAGCATCGCGGTGATCGGATCGTCCTTCGTGGC
TCTCGAACTGGCCCAGGCATATCGCCGTCTCGGCGTCGACGTGACCGTGCTCGCCCGCAGCACCCTGCTCACGCGCGACG
ATCCCGAACTTGGCGCGGCGCTACAGGAGGCGTTTGAAGCCGAGGGCATCCGTGTTCTCAACGAGACCCGGGTTCAGAAC
GTCGCCTATGAGGCTGGTCGTTTCATAGTGGCGTTTGGCACCGGGCGCATCGAAGCCGAGCGGCTACTGGTGGCTACCGG
ACGCTGGCCCACGACTGGAGGACTTGGCCTTGAGCAGGCCGGTGTCACTACCGATCGCAACGGCGCCATCGTGGTCGACG
ACCATCTGCGGACATCAGCCGCGAATATCTACGCGGCAGGCGATTGCAGCACGATGCCGCAGCTCGTCTATGTCGCCGCG
GCGGCCGGAACGCGGGCTGCGATCAACATGACGGGCGGCGACGCCAGCCTCGACCTCTCGGTGGTCCCCGCGGTGATCTT
CACCGACCCTTCGGTCGCGACGGTCGGACTGGACGAGGGGCAGGCGAGAACGGCAGGCATCGAAGCTATCGTGCGGCGCC
TCGATCTGGAAAACGTGCCCAGAGCACTCGCGAATTTCGACACGCGAGGCTTCGTGAAGCTCGTTGCCGAAGCCGGCACC
AACCGGCTGATCGGCGCACAGATCCTCGCTCACAATGCTGGAGAAATGATCCAGACTGCGGCACTCGCCATCCGTCATCG
GATGACGGTGCAGGAGCTGGGCGACACGCTGTTCCCCTATCTGGTGATGAGCGAGGGGATCAAGCTTGCGGCACAGACCT
TTACCAAGGACGTGAAGCAACTCTCCTGCTGCGCCGGGTGA

Protein sequence : 
MTSLTLSVTGMTCEHCARIAEKALNSLPDVRADVNYDRRTARIDGADGLDLAALRAALAPHGYGMETLNDDTTRGTTAPH
GGGLHIAIIGSGGAAFAAAIRAVDAGARVTMIERGEVIGGTCVNAGCVSSKITLRAAEIRHERGHHPFDGIARSEEPVDR
RVLLAQLRGRVDALRGAKYQKIIDDNPGITLLRGEARFADARTLTITEHTGKVTRQTPDRILIATGAAPMIPPVPGLAET
PYWTSTESLFADELPTSIAVIGSSFVALELAQAYRRLGVDVTVLARSTLLTRDDPELGAALQEAFEAEGIRVLNETRVQN
VAYEAGRFIVAFGTGRIEAERLLVATGRWPTTGGLGLEQAGVTTDRNGAIVVDDHLRTSAANIYAAGDCSTMPQLVYVAA
AAGTRAAINMTGGDASLDLSVVPAVIFTDPSVATVGLDEGQARTAGIEAIVRRLDLENVPRALANFDTRGFVKLVAEAGT
NRLIGAQILAHNAGEMIQTAALAIRHRMTVQELGDTLFPYLVMSEGIKLAAQTFTKDVKQLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 4e-118 61
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 1e-127 59
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-125 58
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-125 58
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-125 58
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 4e-123 57
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 3e-123 57
merA AFG30120.1 MerA Not tested PAGI-2 Protein 3e-123 57
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 3e-121 56
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 3e-121 56
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 4e-81 45
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 3e-81 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_004276957.1 mercuric reductase BAC0653 Protein 1e-123 62
merA YP_004276957.1 mercuric reductase BAC0650 Protein 3e-117 60
merA YP_004276957.1 mercuric reductase BAC0652 Protein 1e-122 57
merA YP_004276957.1 mercuric reductase BAC0651 Protein 2e-81 45
merA YP_004276957.1 mercuric reductase BAC0224 Protein 8e-80 45