Gene Information

Name : Sgly_2221 (Sgly_2221)
Accession : YP_004266511.1
Strain : Syntrophobotulus glycolicus DSM 8271
Genome accession: NC_015172
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 2256564 - 2258282 bp
Length : 1719 bp
Strand : -
Note : COGs: COG0804 Urea amidohydrolase (urease) alpha subunit; HAMAP: Urease, subunit alpha; InterPro IPR011612: IPR006680: IPR005848; KEGG: cth:Cthe_1816 urease subunit alpha; PFAM: Amidohydrolase 1; Urease alpha-subunit, N-terminal; PRIAM: Urease; SPTR: Urea

DNA sequence :
ATGGGATTATTGATGGCGAGAAAAGACTATGTGAGCATGTTTGGTCCCACCGTCGGTGACCGGATAAGGCTTGCTGATAC
CGGCCTTATCATTGAGATTGAGCGGGATGATACGGTATACGGTGACGAATGCAAATTCGGCGGCGGCAAGTCGATTCGTG
ACGGAATGGCTCAAGCCTGTGCGGCAACGAGTGCTGAAGGGGCTTTGGATTTATTGATTACGAATGTTGTTATACTTGAC
TACTGGGGTATTGTGAAGGCGGATATTGGGATTAAAGACGGAAAAATTGCCGGCATCGGCAAGGCCGGCAATCCTGCCAT
AATGTCCGGTGTTACAGAGCGGATGATCATCGGCGCGGCGACCGAGGTGATCGCCGGCGAGGGGTTGATTGCGACTGCCG
GCGGAGTGGATACGCACGTTCATTATATTAGTCCCCAACAAGTTGAAGCTGCGCTTTATAGTGGAATAACGACAATGATC
GGTGGGGGAACCGGACCGGCAGACGGTTCAAATGCGACGACCTGTACACCGGGCCCGTGGAATATTAAGAGAATGCTGGA
GGCGGTTGAAGAATTTCCGATGAACTTCGGTTTTCTGGGAAAAGGAAACGCTTCGGATAAAAAACCGTTAATCGAACAAG
TGAAGGCGGGTATTATCGGATTCAAACTCCATGAAGACTGGGGAAGCACTCCGAAAGCCATTGATAACTGCCTTAATGTT
GCTGATTGGTATGACCTCCAGGTTGCCATTCACACCGATACCATTAATGAAGCCGGATATGTCGAAGATACCATCAAGGC
GATAAATGGCCGGACTATTCATACTTATCATACAGAAGGAGCGGGCGGAGGACATGCGCCTGATACCGTTAAACTGGCTG
AGTTTACAAACATTCTTCCTTCGTCTACCACGCCAACATTACCCTATACGGTGAATACTTTCGTTGAACACCTGGATATG
CTGATGGTTTGTCACCACATGGATAAAAATGTGCCGGAAGATGTTGATTTTGCCAATTCTCGGATACGGATCAATACGAT
AGCCGCCGAAGATGTGTTGCATGACAGAGGGGTAATCAGCATGATTAATTCGGACTCTCAGGCCATGGGCAGGGTCGGCG
AAGTGATTATCAGGACATGGCAGACTGCGGACAAAATGAAAAAACAGTTCGGCGCACTGCCGGGTGATGGTCTGAATAAT
GACAACCAAAGAGTCAAACGTTATGTGGCAAAGTATACGATTAATCCGGCAATTACCCATGGTGTGTCAAATCATGTGGG
TTCTTTGGAAACAAAAAAACTGGCGGATATTGTGCTTTGGAAGCCGGCCCTGTTTGGGGTTAAACCGGAAATCATCATCA
AAGGCGGTTGTATCGCGGCAAGCAGAATGGGAGATGCCAACGCGTCCATCCCAACTCCGCAGCCTGTGATCTACCGTAAT
ATGTTTGGGGCGTTCGGCAGGGCCAAATATAAAAATTCAGTTACGTTTGTTTCGGGTGAGTCAATTAATAACGGCATAGC
AGAAGAGTTGAGTTTGCACAAGATAATATATCCTGTTGCCGGCTGCAGGAACATCACGAAGAAGAATATGATGTTCAACG
ATGCCACACCACATATTGAAGTGAACCCAAATACCTTTGAGGTAAAGCTGGACGGCCAGGTTATAACGTGTGAACCGGCG
CAAAGCCTTCCGTTAACGCAGCGTTATTTTATGTTTTAA

Protein sequence :
MGLLMARKDYVSMFGPTVGDRIRLADTGLIIEIERDDTVYGDECKFGGGKSIRDGMAQACAATSAEGALDLLITNVVILD
YWGIVKADIGIKDGKIAGIGKAGNPAIMSGVTERMIIGAATEVIAGEGLIATAGGVDTHVHYISPQQVEAALYSGITTMI
GGGTGPADGSNATTCTPGPWNIKRMLEAVEEFPMNFGFLGKGNASDKKPLIEQVKAGIIGFKLHEDWGSTPKAIDNCLNV
ADWYDLQVAIHTDTINEAGYVEDTIKAINGRTIHTYHTEGAGGGHAPDTVKLAEFTNILPSSTTPTLPYTVNTFVEHLDM
LMVCHHMDKNVPEDVDFANSRIRINTIAAEDVLHDRGVISMINSDSQAMGRVGEVIIRTWQTADKMKKQFGALPGDGLNN
DNQRVKRYVAKYTINPAITHGVSNHVGSLETKKLADIVLWKPALFGVKPEIIIKGGCIAASRMGDANASIPTPQPVIYRN
MFGAFGRAKYKNSVTFVSGESINNGIAEELSLHKIIYPVAGCRNITKKNMMFNDATPHIEVNPNTFEVKLDGQVITCEPA
QSLPLTQRYFMF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 3e-147 63
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 3e-147 63
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 8e-143 59
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-143 59
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 4e-143 59
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-143 59

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Sgly_2221 YP_004266511.1 urease subunit alpha VFG0270 Protein 2e-158 65