Gene Information

Name : Thebr_0702 (Thebr_0702)
Accession : YP_004185679.1
Strain : Thermoanaerobacter brockii Ako-1
Genome accession: NC_014964
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.9.2
Position : 727879 - 729630 bp
Length : 1752 bp
Strand : +
Note : TIGRFAM: pyruvate kinase; KEGG: tpd:Teth39_0684 pyruvate kinase, pyruvate, water dikinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region

DNA sequence :
ATGCGCAGAACAAAAATAGTGTGTACAATAGGACCTGCCAGCGAAGACTATAATATACTGAGAAAATTAATTGAGAAAGG
TATGAACGTTGCTCGATTGAATTTTTCTCATGGGGATTTTGAAGAGCATGGGGCAAGAATTGACAATATTAAAAAGATAA
GAGAAGAATTCGGGCTACCTGTTGCTATTTTGTTGGATACTAAAGGTCCAGAGATAAGGACAGGAAAGTTTAAAAATGGC
GGAGTGGAATTAAAAGAAGGACAAACTTTTGTCATTACGACAAGAGATGTATTAGGAGACGAAACTATATGCAGTGTATC
CTATAAAGGGTTGCCTCAAGATGTGGAAAGAGGTAGCCGCATACTAATTGACGATGGGTTAATTTCTCTAAAGGTTACTG
ATGTTAAAGGAGAAGATATAGTTTGTATTGTAGAAAATTCTGGTCCTGTAAAAGACCATAAAGGAGTAAATGTTCCAGGA
GTAAAACTCAATCTTCCTGCTTTGACTCAAAAAGACGTAGATGATATAGAGTTTGGAATTAAAAAAGGTATTGATATAAT
TGCGGCTTCTTTTGTTAGAAAAGCAGCTGATGTTTTGGCAATAAGAAGACTTTTAGAAGAAAATAAGGCAGAGCATATTT
TAATTATTGCTAAGATAGAAAATCGCGAAGGAGTAGAAAATATAGACGAAATCATTAAGGTTTCAGATGGAATAATGGTA
GCCAGAGGAGATTTAGGTGTTGAGATTCCTCTTGAAGAAATACCAATCGTTCAAAAGATGATTATACAAAAATGCAATAA
AGCAGGGAAACCTGTAATTACTGCAACTCAAATGTTAGACTCTATGATGAGAAATCCAAGGCCTACAAGAGCAGAAGTTA
CAGATGTAGCAAACGCTATTCTAGATGGGACAGATGCTATAATGCTATCAGGGGAGACAGCTCAAGGTAAATACCCCATA
GAGGCCTTTGAGACAATGGCAAAGATTGCAGAAAAGACAGAAGCTTATGTGGGATACAGAGATATCATTGATAGAAATAT
TGATACAAATGTTTCTATTACAAACGCTATAAGCCATGCAACTTGTACTACTGCAAGAGATATAGGTGCAGCTGCTATAA
TAACTTGTACTAAATCTGGCTATACAGCGAGAATGGTATCAAGGTACAGACCTCAAGCTCCGATTATTGCTACTACTCCA
AGCGAAAGTGTTGCAAGGAAGCTCTCTATAGTCTGGGGAGTATATCCTTTAGTTACAGAAGAGGTTTCTACTACAGATGA
AATGATAGATGTTGCAATACAAAGTGCTTTAACTGCTGGACTTATAAGAAATGGCGATATCGTAGTAATTTCTGCAGGAA
TTCCTGTAGCTATGACAGGTACCACCAACATGTTGAAGGTACATATAGTAGGAGATGTTTTGTTGAGAGGAATAGGTATA
GGTTCTAAGGCTACTACAGGTGTTGTATGTGTTATTAATGATATCAGCAAAGACAAAGATAAATTTAGAGAAGGCGATAT
AATAGTAACTGCAAAGACAGAAAGAGATTTTATGCCTCTTATAGAGAAAGCTTCTGCTATAATCACAGAAGAAGGAGGGC
TTACTTCTCACGCAGCTATTGTGGGATTAAACTTAGGAATTCCTGTAGTTGTAGGTTGTGAAGGAGCGACTTCTAAATTA
AAAGATGGCATGACTGTAACGGTTGACACAGTTAGAGGATTTGTGTATAAAGGAATTGTAAATATTAAATAA

Protein sequence :
MRRTKIVCTIGPASEDYNILRKLIEKGMNVARLNFSHGDFEEHGARIDNIKKIREEFGLPVAILLDTKGPEIRTGKFKNG
GVELKEGQTFVITTRDVLGDETICSVSYKGLPQDVERGSRILIDDGLISLKVTDVKGEDIVCIVENSGPVKDHKGVNVPG
VKLNLPALTQKDVDDIEFGIKKGIDIIAASFVRKAADVLAIRRLLEENKAEHILIIAKIENREGVENIDEIIKVSDGIMV
ARGDLGVEIPLEEIPIVQKMIIQKCNKAGKPVITATQMLDSMMRNPRPTRAEVTDVANAILDGTDAIMLSGETAQGKYPI
EAFETMAKIAEKTEAYVGYRDIIDRNIDTNVSITNAISHATCTTARDIGAAAIITCTKSGYTARMVSRYRPQAPIIATTP
SESVARKLSIVWGVYPLVTEEVSTTDEMIDVAIQSALTAGLIRNGDIVVISAGIPVAMTGTTNMLKVHIVGDVLLRGIGI
GSKATTGVVCVINDISKDKDKFREGDIIVTAKTERDFMPLIEKASAIITEEGGLTSHAAIVGLNLGIPVVVGCEGATSKL
KDGMTVTVDTVRGFVYKGIVNIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 7e-106 51
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 5e-106 51
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 5e-106 51
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-105 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Thebr_0702 YP_004185679.1 pyruvate kinase VFG0479 Protein 2e-106 51