Gene Information

Name : Thebr_0193 (Thebr_0193)
Accession : YP_004185204.1
Strain : Thermoanaerobacter brockii Ako-1
Genome accession: NC_014964
Putative virulence/resistance : Resistance
Product : D-alanine/D-alanine ligase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1181
EC number : -
Position : 202914 - 203993 bp
Length : 1080 bp
Strand : +
Note : KEGG: tpd:Teth39_0187 D-alanyl-alanine synthetase A; TIGRFAM: D-alanine/D-alanine ligase; PFAM: D-alanine--D-alanine ligase domain protein

DNA sequence : 
ATGGAAAAGAAGAAAATAGCTGTTTTATTTGGCGGACAATCAGGAGAACATGAAGTTTCTTTAATGTCTGCAAAGTCTAT
AATAAACAACCTTGATAAAGATAAATACGAGATTTACATGGTAGGTATTACAAAAAAAGGAGAATGGTATCTGTATAGAG
GAGATGTGGGGAAAATAGAAACTGGAGAATGGGAAAAAGAAGGAATTCCTGCAATTATGGGAGCTTCTACAAAGTATAGA
GGAATAATAACTTTCGAAGATGGAGAAAACGGTTTTTATCCTATAGACGTGGTATTTCCTGTTTTACATGGTCCTAATGG
AGAAGATGGGACTATACAAGGGCTTTTAGAACTATTAGACATGCCTTATGTAGGTGCTAATGTGCTTTCTTCTGCTTTAT
GCATGGATAAAGTTTTTACAAAAAGAATTTTTAAGGAAGCGGGGTTACCTACACCTGATTTTGTAGTAGTGTATGGAAAA
GAGATTGAAGACTTAGAAGCTATAAAGAAAAAAATTGAACACTTAGGATATCCTTGTTTTGTAAAACCTGCTAATTTGGG
GTCGAGTGTTGGCATTACTAAAGTCCACAACGAGGAAGAACTTCCTGGGGCCTTGAAATTAGCTGCGAAATATGATAGAA
AATTATTAATAGAAAGAGGAATAGATGCCAGAGAGATTGAATGCTCTGTTTTGGGTAATGAAAATCCCGAGGCCTCTATT
GCAGGAGAAATTGTTCCTTCTAATGAATTCTATGATTATAATGCTAAATATTTTGATGGGGGTAAATCTCTTCTCTTAAT
ACCTGCACCACTTCCAGATGAAAAAATGGAAGAGGTAAGAAAGCTTGCTATAAAGGCCTACAAAGCTTTGGATTTGAGAG
GTATGGCGAGAGTAGACTTTTTAATGGATAGAAATACAGGTACTCTTTATTTAAATGAAGTTAATACCATTCCGGGGTTT
ACAAAAATAAGCATGTATCCCAAATTATGGGAATCAAGTGGAAAGTCTTATTCAACATTATTGGATGAGCTTATAAACTT
AGCAGTAGAGAGCCATAATGAAAAATGTAGGGAATGGTGA

Protein sequence : 
MEKKKIAVLFGGQSGEHEVSLMSAKSIINNLDKDKYEIYMVGITKKGEWYLYRGDVGKIETGEWEKEGIPAIMGASTKYR
GIITFEDGENGFYPIDVVFPVLHGPNGEDGTIQGLLELLDMPYVGANVLSSALCMDKVFTKRIFKEAGLPTPDFVVVYGK
EIEDLEAIKKKIEHLGYPCFVKPANLGSSVGITKVHNEEELPGALKLAAKYDRKLLIERGIDAREIECSVLGNENPEASI
AGEIVPSNEFYDYNAKYFDGGKSLLLIPAPLPDEKMEEVRKLAIKAYKALDLRGMARVDFLMDRNTGTLYLNEVNTIPGF
TKISMYPKLWESSGKSYSTLLDELINLAVESHNEKCREW

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 4e-56 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Thebr_0193 YP_004185204.1 D-alanine/D-alanine ligase AY489045.gene.p01 Protein 7e-56 42
Thebr_0193 YP_004185204.1 D-alanine/D-alanine ligase AF277571.gene.p01 Protein 5e-56 42
Thebr_0193 YP_004185204.1 D-alanine/D-alanine ligase U00456.gene.p01 Protein 2e-56 41
Thebr_0193 YP_004185204.1 D-alanine/D-alanine ligase U35369.1.gene6.p01 Protein 2e-56 41
Thebr_0193 YP_004185204.1 D-alanine/D-alanine ligase AE016830.1.gene2250. Protein 2e-56 41
Thebr_0193 YP_004185204.1 D-alanine/D-alanine ligase AF130997.1.orf4.gene Protein 9e-54 41