Gene Information

Name : Isop_0423 (Isop_0423)
Accession : YP_004177567.1
Strain : Isosphaera pallida ATCC 43644
Genome accession: NC_014962
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.99.3
Position : 606178 - 607680 bp
Length : 1503 bp
Strand : +
Note : COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: aba:Acid345_1381 aldehyde dehydrogenase (acceptor); PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde dehydrogenase (Acceptor); PFAM: Aldehyde dehydrogenase family

DNA sequence : 
ATGTCCGTTTCCACTTTGGACCCAACCCGCCACGCGCCGGTGGTCCCTAAGTTCAAGCCTCAAGGAATGTTGATCGACGG
CCGTTGGACCCAGGCGGTTGATGACGAGAATTTCGAGACGATCGACCCGGCGACCGAAACGGTGCTGGCGCATGTGCCTT
CGGGGGGGCGAGTGGATATCGACCTGGCGGTGAAGGCGGCCCGCCAGGCGTTCGAGTCGGGTCCGTGGCCCAAGATGACT
CCCTCGGAGCGGGGCCGTTTGCTTTGGAAACTGGCCGATCGTCTGGAGGAATGCCGCGACGAGTTCGCCGAACTCGAGTC
GCTGGACAACGGCAAGCCGCTGGCCGTCGCGCGGGTCGCTGACGTGCCGCTGGCGGTCGATCTGTTCCGCTACATGGCCG
GTTGGGCCACCAAGATCGAGGGCAAAACCATCCCGATTTCAGCTCCCACCGCGCCTGGGGCGGAGTTCCTGGCGATGACC
CTGCGCGAGCCGATCGGTGTGGTCGGTCAGATCATTCCCTGGAACTTCCCGTTGCTGATGGCCGCCTGGAAGCTCGGTCC
GGCCCTGGCCACGGGTTGCACGGTGATCCTCAAGCCGGCGGAACAAACTCCGCTTTCGGCTCTAAGGCTGGGCGAACTGA
TCCAAGAGGTCGGCTTCCCTGCCGGGGTCGTCAACATCGTCACCGGCTTCGGCGCGACGGCCGGGGCGGCCCTGGCGGCG
CACCCCGACGTGGACAAGGTGGCGTTCACCGGCTCGACCGAGGTGGGCCGGGCGATTGTTCAGGCGGCGGCGGGCAACCT
CAAGCGGGTTACCTTGGAACTCGGCGGCAAGAGCCCCAACGTCGTTTTCGCCGACGCCGATCTCGAGACCGCGATCCCCG
GCGCGGCCAACGCGATCTTCTTCAACCACGGGCAATGCTGTTGCGCAGGCAGCCGTCTGTATGTGCAACGCTCGATCTTT
GATCGGGTGGTCGAGGGAGTCGCCAACCACGCCCGTTCGATCAAACTGGGACATGGTCTGGACGAATCCACTCAAATGGG
GCCGTTGATCTCGAACGAGCAGCTTCAGCGGGTCAATGGTTTTCTGGAGTCCGGAGTCCGCGAAGGGGCGCGGGCGGTGG
TAGGCGGCGGTCGGGTGGGGCATCGGGGGTTCTTCGTGGAGCCGACGGTGCTGGTTGATGTCAAGCCGACGATGAAGGTG
GTCTGCGAGGAGATTTTCGGCCCGGTGGTCACGGCGATGCCGTTCGACGACCCGGCCCAGGTCGAACCAGCGGCCAATGA
AACGATCTACGGTCTGGCCGCCGGCATCTGGACCCGCGATATTGGCAAAGCGCACCGGCTGGCCAAGCGACTTCGCGCGG
GGACGGTTTGGATCAACTGCTACAACATCTTCGACGCCGCCTTGCCCTTTGGCGGCTACAAGCAGTCCGGTTGGGGGCGC
GAAATGGGCTACGAGGCGATTCAGCTTTACACCGAGACCAAGTCGGTCTGCATCGGTCTGTGA

Protein sequence : 
MSVSTLDPTRHAPVVPKFKPQGMLIDGRWTQAVDDENFETIDPATETVLAHVPSGGRVDIDLAVKAARQAFESGPWPKMT
PSERGRLLWKLADRLEECRDEFAELESLDNGKPLAVARVADVPLAVDLFRYMAGWATKIEGKTIPISAPTAPGAEFLAMT
LREPIGVVGQIIPWNFPLLMAAWKLGPALATGCTVILKPAEQTPLSALRLGELIQEVGFPAGVVNIVTGFGATAGAALAA
HPDVDKVAFTGSTEVGRAIVQAAAGNLKRVTLELGGKSPNVVFADADLETAIPGAANAIFFNHGQCCCAGSRLYVQRSIF
DRVVEGVANHARSIKLGHGLDESTQMGPLISNEQLQRVNGFLESGVREGARAVVGGGRVGHRGFFVEPTVLVDVKPTMKV
VCEEIFGPVVTAMPFDDPAQVEPAANETIYGLAAGIWTRDIGKAHRLAKRLRAGTVWINCYNIFDAALPFGGYKQSGWGR
EMGYEAIQLYTETKSVCIGL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 2e-77 47
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-76 44
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 2e-78 44
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 2e-78 44
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 2e-78 44
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 5e-78 44
unnamed AAK01506.1 putative aldehyde dehydrogenase Not tested PAGI-1 Protein 1e-77 42
hpaE AAO17179.1 HpaE Not tested tcd island Protein 1e-68 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Isop_0423 YP_004177567.1 aldehyde dehydrogenase VFG0082 Protein 1e-76 44