Gene Information

Name : Isop_1288 (Isop_1288)
Accession : YP_004178423.1
Strain : Isosphaera pallida ATCC 43644
Genome accession: NC_014962
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.99.3
Position : 1849373 - 1850842 bp
Length : 1470 bp
Strand : +
Note : COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160: IPR001261; KEGG: plm:Plim_1868 retinal dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Retinal dehydrogenase; PFAM: Aldehyde dehydrogenase family

DNA sequence : 
ATGGTCGCCACCGCCTCTCCCATTCAGGCTCCACCGATTCATCAAACACGACTTCTTATCAACAACGAGTGGGTCGACGC
CTCCGACGGTGCGACCTTCGAAACCCTCAACCCCGCCACCGGTGAGGTCATTGCCCGCGTGGCCCACGCCACGGCTCAGG
ATGTGGATCGCGCTGTCAAAGCGGCCCGCAACGCGCTGGAACACGGTCCCTGGGGACGCATGGACGCCCCCGATCGGGGT
CGTTTGTTGCTCAAGCTCGCCGATCTGGTCGAAGCTCACGCCAACGAACTGGCAGCGCTGGAGTCACTCAACTGCGGCAA
GACGATCCGCGATTCGCGGGGCGACGTTCAAGCCGTCGCCAACACCCTTCGCTATTACGGTGGCTGGGCCGACAAGATCG
AGGGCCGGGTGGTGCCGACCCGGGGCTCGTTCCTGAGCTACACCCTCCGACAGCCCGTCGGGGTCGTCGGACAAATCATC
CCCTGGAATTTTCCGCTGTTGATGCTCGCCTGGAAGTGGGGTCCAGCCCTGGCCGCCGGTTGCACGGTGGTCATGAAGCC
GGCCGAACAAACCCCCCTCTCCGCGCTCCGCATGGGTGAACTGGCCATCGAGGTCGGGTTCCCGCCCGGCGTGATCAATC
TGGTCAACGGCATGGGCGAAACCATGGGCGACGCCCTGGTTGTTCACCCTGACGTGGATAAAATCGCGTTTACTGGTCAT
GTGGACACCGCCAAAATCATTCAAAAGCGCGCCGCCGATACCCTCAAGCGGGTCACCTTCGAGTTGGGCGGCAAGAGTCC
CAACGTGGTTTTCGCCGACGCGGATCTCGATCAAGCGGTGGAGGGAGCGTTCCACTCGATCTATTTCCACGGTGGCCAGT
GTTGCACCGCGGGCAGCCGGTTGTTCGTGGAGAAGTCGATTCACGCGGAATTCGTCGAACGTCTGGCCGCCAAGGCCCGC
GCTCGCAAACTCGGTGATCCACTCGACCCCACCACCGAGCAGGGTCCCCAGGTCTCGCGCGAACAACTCGACAAGATTCT
GAGCTACATCCAACTGGGACAACAGGAGGGAGCTCGACTTGTCACCGGCGGACGGACTCCCAGCGAACGCGGCTTCTATG
TGGAACCAACCATCTTCGACAACGCCCGCGACGACATGAAACTCGTCCGTGAGGAGATCTTCGGCCCCGTCGTAGCCGTC
CTCCCCTTCGAATCGATGCGCGACCTCATCCCCCGCGCCAACGACACCACCTATGGCCTGGCGGCGGCTATCTGGACCAA
AGACCTCGACAAAGCCCACCTCTACGCACAAAAGGTCAAAGCCGGCACCGTGTGGGTCAACTGCTATCACGTTGTTGATA
CATGCACCCCATTTGGTGGCTTCAAGATGTCGGGCCAGGGTCGTGAGAATGGCGAGGAGGCGCTCGACCACTACACCGAG
ACCAAGACGGTGACGATCAAGCTGGGCTAA

Protein sequence : 
MVATASPIQAPPIHQTRLLINNEWVDASDGATFETLNPATGEVIARVAHATAQDVDRAVKAARNALEHGPWGRMDAPDRG
RLLLKLADLVEAHANELAALESLNCGKTIRDSRGDVQAVANTLRYYGGWADKIEGRVVPTRGSFLSYTLRQPVGVVGQII
PWNFPLLMLAWKWGPALAAGCTVVMKPAEQTPLSALRMGELAIEVGFPPGVINLVNGMGETMGDALVVHPDVDKIAFTGH
VDTAKIIQKRAADTLKRVTFELGGKSPNVVFADADLDQAVEGAFHSIYFHGGQCCTAGSRLFVEKSIHAEFVERLAAKAR
ARKLGDPLDPTTEQGPQVSREQLDKILSYIQLGQQEGARLVTGGRTPSERGFYVEPTIFDNARDDMKLVREEIFGPVVAV
LPFESMRDLIPRANDTTYGLAAAIWTKDLDKAHLYAQKVKAGTVWVNCYHVVDTCTPFGGFKMSGQGRENGEEALDHYTE
TKTVTIKLG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 3e-88 47
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-89 45
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 1e-91 45
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 1e-91 45
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 1e-91 45
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-91 45

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Isop_1288 YP_004178423.1 aldehyde dehydrogenase VFG0082 Protein 5e-90 45