Gene Information

Name : Tmar_1627 (Tmar_1627)
Accession : YP_004102463.1
Strain : Thermaerobacter marianensis DSM 12885
Genome accession: NC_014831
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1962167 - 1963537 bp
Length : 1371 bp
Strand : +
Note : COGs: COG0626 cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: mta:Moth_1989 cysteine synthase / cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: cystathionine gamma-synth

DNA sequence :
ATGCAGGTTGAACCCGGCCCTGGCGGCGCCCCCTCGGGCGCCGGCGGCCACGCGCCCCTTCACGGCGCGCCCGTCGCGCC
GGCGGCCCCGCCGCGCACCCTGCGGGTGGAGACGCGGGTCGTCCACGCAGGCGTCCGCCGCGACCCGCGGACCGGGTCGG
TGTCCGTACCGATCTATCAGACGGCCACCTACGAGCACCCCGGACCCGGCCAGACCACAGGGTGGGACTACAGCCGGCTG
CACAACCCGACCCGGGAGGCCTTCGAGGCCGCGGTGGCGGCCCTGGAGGACGGCTTCGCGGCCCTGGCCTTCGCCTCGGG
GATGGCGGCCATCACGGCGGTCCTGCACCTCTTCAAGCCCGGCGACCACCTGGTGGTGACCGAAGACCTCTACGGCCACA
CCTGGCGGGTGCTGGAGGAGCTCTTCCGCCACCTGGGCGTCGCCTACACCCTGGCCGACACCACCGATGCCGCGGCCGTG
GCGGCCGCCCTGACCCCGGCGACCCGGGCGGTGCTGGTGGAGAGCCCCACCAACCCCCTGATGCGGGTGGCCGACCTGGA
CGGCCTGGCCGCCCTGTGCCGCGCCCGGCGGCTGTGGCTGATCGTCGACTCGACCCTCTTCACGCCGCTGTTCCAGCGGC
CCCTGGCCCGGGGCGCCCACGTGGTGATCCACAGCGCCAGCAAGTACCTGGCGGGGCACAACGACGTGGTGGCGGGGGTG
GCCGTGGCGGACGGTCCGGCACTGGCGGACGAACTGGCCTCCATCCGCACGGTGACGGGCGGGATCCTGGGGCCCCACGA
CGCCTGGCTGGCCGTCCGCGGCCTGAAGACCCTGGCCCTGCGCATGGAGCAGGCCCAGCGGAACGCCCTGACCCTGGCCC
ACTGGCTGGCGGCCCACCCCGCCGTGGCGGCGGTCTATTATCCCGGGCTGCCGTCGAGCCCGTTCCACCGGCGGTGTGTG
GAGCAGGCGGCGGGGTTTGGCGCCATGCTGAGCTTCCGGCTGCGCGAGCCCGGGAAGGCCGACCAGGTGCTCCGGCGCCT
GGGGCTGGTCATCTTCGCCGAGAGCTTCGGCGGGGTCGAGAGCCTGATCACCCACCCGGCCAGCACGACCCACAAGGAGA
TGCCCCTGGCGCTGCGAGAGCGGCTGGGCATCGACGCCGGGCTGCTGCGGCTGTCGGTGGGCATCGAGGCGGTGGAGGAC
CTGGCCGCCGACCTGGAGTACGCCCTGGAAGGGCCGTCGGGGCTGCCGGTGGCGGAGGCACGGCAACGGGCAGAAGCGAC
GCTGGCCGCCCTCTCGGGCCGGGAGGCGTCGAAGCCCTGCGCGGCCGGCCGGGCGACGGGCGTGGAACCGGCACCTGGCG
CAGCGCATTGA

Protein sequence :
MQVEPGPGGAPSGAGGHAPLHGAPVAPAAPPRTLRVETRVVHAGVRRDPRTGSVSVPIYQTATYEHPGPGQTTGWDYSRL
HNPTREAFEAAVAALEDGFAALAFASGMAAITAVLHLFKPGDHLVVTEDLYGHTWRVLEELFRHLGVAYTLADTTDAAAV
AAALTPATRAVLVESPTNPLMRVADLDGLAALCRARRLWLIVDSTLFTPLFQRPLARGAHVVIHSASKYLAGHNDVVAGV
AVADGPALADELASIRTVTGGILGPHDAWLAVRGLKTLALRMEQAQRNALTLAHWLAAHPAVAAVYYPGLPSSPFHRRCV
EQAAGFGAMLSFRLREPGKADQVLRRLGLVIFAESFGGVESLITHPASTTHKEMPLALRERLGIDAGLLRLSVGIEAVED
LAADLEYALEGPSGLPVAEARQRAEATLAALSGREASKPCAAGRATGVEPAPGAAH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-45 44
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-47 44
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 7e-34 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tmar_1627 YP_004102463.1 cystathionine gamma-synthase BAC0207 Protein 5e-30 42