Gene Information

Name : Mspyr1_21280 (Mspyr1_21280)
Accession : YP_004076617.1
Strain : Mycobacterium gilvum Spyr1
Genome accession: NC_014814
Putative virulence/resistance : Virulence
Product : peptide arylation enzyme
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 2182750 - 2184438 bp
Length : 1689 bp
Strand : -
Note : PFAM: AMP-binding enzyme; TIGRFAM: 2,3-dihydroxybenzoate-AMP ligase

DNA sequence : 
ATGACCACTGGATTCCCGATCGAAGACAGCCATGACCTAACAAACGGCGACCTGACAAACGGCGACCTGGCGCACGGCTT
CGTCCCCTTCCCCGAGGATCGCGCCGAGGCCTACCGGCGGGCCGGCTATTGGACGGGACGGCCGCTCGACTCGATCCTGA
CCGACGCGGCCTCCCGGTGGCCGGACAAGCCGGCGATCATCGACGCCACGCGCAGCTACACGTTCGCCGAGCTGGACGCC
GCCGCCGACCGGGCCGCCGCGGGGCTGGCCGACCTCGGCATCCGCCCGGGAGAGCGGGTGCTGCTGCAGCTGCCGAACTC
GTGCCAGTTCGCCGTCGCGCTCTTCGCCCTGCTGCGGGCCGGCGTCGTACCCGTGATGTGCCTGACCGGGCACCGTACGG
CAGAACTCGGTCACTTCGCCGACGTCAGCGGCGCGGTCGCGGTGATCGTTCCCGACCGGGCGGGAGGGTTCGACTACCGC
GACATGGCGGCCTCGCTCGCCGCGCAACGTCCGGCACTGCGCCACGTGATCGTCGACGGCGAACCCGGCGATCAGGTCTC
GTGGCAGTCGATCCTCGACTTCGCCGGGCCACGTCTCGGGCGCACGCCAGTCGATCCGTCGCTTCCGGCGCTGTTGCTGG
TCTCGGGCGGAACCACGGGGCTGCCCAAGCTCATCGCACGCACCCACGACGACTACGTCTACAACGCGCATGCCTGCGCG
CAGGCATGCGAGATGACCGGTGAGGACGCCTATCTCGTTGCGCTGCCCGCGGGGCACAACTTCCCGCTGGCCTGTCCCGG
GCTGCTCGGGTCGATGACGGTCGGAGCGCCGACGGTGTTCACCGCAGACCCCAGCCCGGAGAACGCCTTCGCGTTGATCG
ACAAGCATCGGATCACGGTGACCGGGTTGGTGAACGCACTGGCCAAGTTGTGGGCGCAGGCGTGCGACTGGGAGCCGGTG
CTGCCGACGTCACTGCGGTTCGTCCAGGTCGGCGGGTCGCGGATGAGCCCGGAGGAAGCGCGTTTCATCCTCGACCGGCT
CACCCCGGGAATGTCGCAGATCTTCGGCATGGCCGAGGGGATGCTCAACTTCACCCGGCCCGGCGATCCCGAGGACGTCG
TGGTGCACACGCAGGGACGGCCGATGTCGCCGCACGACGAGATGCGCGTCGTCGACGAGGACGGTGTCGAGGTCGCACCC
GGCGAGGAGGGCGAGCTGCTGGTCCGGGGGCCCTACACGCTCAATGGGTACTACCGGGCCGACGACGCCAACGCCCGCTC
CTTCACGCCGGACGGCTTCTACCGCACGGGTGACCGGGTCCGGATCTTCACCGACGGGCCCCGTGCCGGGTACGTCGAGG
TCACCGGCCGGGTCAAGGACGTGATCCACCGCGGTGGTGAGACGGTGTCGGCGACCGACCTTGAGGATCACCTGCACACC
CACCCGTCCGTCTACGCGGCGGCCGCAGTGGCGCTGCCCGACGAGTACCTGGGCGAGAAAATCTGCGCTGCAGTCGTTTT
CACGGGACCGCCGCTCACGCTCGCCGATCTCAATGCATTCCTCGACGAGCGCGGCGCCTCCACGCACGCGCGTCCCGATG
TGCTGGTTCCGGTACCGTCGCTGCCGACGACAGCGGTGGGCAAGGTCGACAAGAAGGCACTCGTGGCGCAGTTGACGGCG
AATTCCTAG

Protein sequence : 
MTTGFPIEDSHDLTNGDLTNGDLAHGFVPFPEDRAEAYRRAGYWTGRPLDSILTDAASRWPDKPAIIDATRSYTFAELDA
AADRAAAGLADLGIRPGERVLLQLPNSCQFAVALFALLRAGVVPVMCLTGHRTAELGHFADVSGAVAVIVPDRAGGFDYR
DMAASLAAQRPALRHVIVDGEPGDQVSWQSILDFAGPRLGRTPVDPSLPALLLVSGGTTGLPKLIARTHDDYVYNAHACA
QACEMTGEDAYLVALPAGHNFPLACPGLLGSMTVGAPTVFTADPSPENAFALIDKHRITVTGLVNALAKLWAQACDWEPV
LPTSLRFVQVGGSRMSPEEARFILDRLTPGMSQIFGMAEGMLNFTRPGDPEDVVVHTQGRPMSPHDEMRVVDEDGVEVAP
GEEGELLVRGPYTLNGYYRADDANARSFTPDGFYRTGDRVRIFTDGPRAGYVEVTGRVKDVIHRGGETVSATDLEDHLHT
HPSVYAAAAVALPDEYLGEKICAAVVFTGPPLTLADLNAFLDERGASTHARPDVLVPVPSLPTTAVGKVDKKALVAQLTA
NS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 4e-92 44
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-92 44
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 5e-92 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-92 44
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-92 44
ybtE CAA21394.1 - Virulence HPI Protein 5e-92 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 9e-91 44
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-90 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 6e-92 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mspyr1_21280 YP_004076617.1 peptide arylation enzyme VFG1817 Protein 7e-171 65
Mspyr1_21280 YP_004076617.1 peptide arylation enzyme VFG0168 Protein 6e-88 42