Gene Information

Name : Mspyr1_10670 (Mspyr1_10670)
Accession : YP_004075587.1
Strain : Mycobacterium gilvum Spyr1
Genome accession: NC_014814
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 1077952 - 1079667 bp
Length : 1716 bp
Strand : -
Note : PFAM: Urease alpha-subunit, N-terminal domain; Amidohydrolase family; TIGRFAM: urease, subunit alpha

DNA sequence :
ATGGGGCACCGGATCTCCCGCAGTCACTACGCCGAGCTCTACGGCCCCACCACCGGTGACCGGGTCCGCCTCGCCGACAC
CGAACTGCTGGCCAAAGTCGAACACGATGCCACGGTCTACGGCGACGAGTCGGTGTTCGGCGGCGGCAAGACCATGCGTG
AGGGCATGGCGGTGCACGGCGACATCACCAACGCAGACGGCGCGCTGGACTTCGTCATCACCAACGTCCTGATCATCGAT
GCGGTGCTGGGAATCCGCAAGGCCGACATCGGGATCCGCGACGGACGCATCGCCGGCATCGGCAAGTCCGGGAACCCGCG
CACCATGGACGGCGTCGACCCGGACCTGGTCATCGGTGCGGGCACCGACATCCGGGCCGGCGAGGGCATGATCGCGACCG
CGGGCGGCATCGACGTCCACGTCCATTTCGACAGCGCCGGTCTGGTCGAGGAAGCGATCTCAAGTGGGATCACCACGATG
ATCGGCGGCGGGTTGGGCCCGGTGACCGTCGGCATCACGACGTCGGGTCCCAACAATCTCGCCCGGATGCTGCGCGCCGC
AGAGGGATTCCCGATGAACTTCGGGTTCATCGCCAACGGCAGCGCGTCGAGTACCGCTCCGCTGATCGAACAGGGTCTCG
CCGGGGCCATCGGCTACAAGATCCACGAGGACTGGGGCGCCACCCCCGCGGCGATCCGGGCGTCCCTGGACGCGGGCGAC
GAACTCGATCTGCAGGTGCAGATCCACACCGACACCCTCAACGAGTCCGGGTTCTTCGAGGACACGATGCGCGCGATCGG
CGGACGCCCGATCCACACCTATCACGCCGAGGGTGCCGGGGGCGGGCATGCGCCCGACATCATGCGCGTCGTCGGCGAGC
CGTACTGCCTGCCGTCGTCGACCAATCCGACCAACCCCTACACGCTCAACACCTTCGACGAGCACCTCGACATGGTGATG
GTGTGCCACCACCTCAACCCGCGCATCCCCGAGGACGTCGCGTTCGCCGAGTCGAGGATCCGCCGAGAGACCATCGCCGC
CGAGGACGTGCTGCACGACCTCGGCGCGATCTCGGCCATGGGTTCGGACTCCCAGGGCATGGGCCGGATCGGCGAGACCA
TCGCGCGGACATGGCAACTCGCCTCCCACATGCGCGCCACCCGGGGCCCGCTGCCCGGCGACGAGGGCACCGGCGCGGAC
AACGCGCGGATCCTGCGTTACGTCGCCAAGCTGACCATCAACCCGGCTCGGCTGTTCGGCATCGACCACGAGGTCGGGTC
ACTGGAGCCGGGCAAGCTCGCCGACATCGTGTTGTGGGAACCGAAGTTCTTCGGTATCAGGCCCGAAGTGGTGTTCAAGG
GCGGCTTTCCGGCATGGTCGGTGATGGGCGAGGCCAACGCGTCGCTGATGACGTGCGAGCCGTTGCGATACCGACCGCAG
TGGGCGGCGTTCGGACGGGCACCCGCCGACGTGTCGGTGAACTTCGTCGCCGGCGCCGCGATCGACGCCGGCCTCGGACA
GCAGCTGGGTCTGGACACCCGACTGGTGGCGTGCCGGGGCGCCCGCGCCCTGACGAAGGCCGACCTCCTGCACAACGACC
ACCTGCCCGACATCAGGATCGAGCCCGACACCTACCGCGTCACCGTCGACGGGCAGCCGTGCGTGAGCACACCGATGACC
GAAGTACCGCTGGGCCGCCGGTACACGCTCAAATAG

Protein sequence :
MGHRISRSHYAELYGPTTGDRVRLADTELLAKVEHDATVYGDESVFGGGKTMREGMAVHGDITNADGALDFVITNVLIID
AVLGIRKADIGIRDGRIAGIGKSGNPRTMDGVDPDLVIGAGTDIRAGEGMIATAGGIDVHVHFDSAGLVEEAISSGITTM
IGGGLGPVTVGITTSGPNNLARMLRAAEGFPMNFGFIANGSASSTAPLIEQGLAGAIGYKIHEDWGATPAAIRASLDAGD
ELDLQVQIHTDTLNESGFFEDTMRAIGGRPIHTYHAEGAGGGHAPDIMRVVGEPYCLPSSTNPTNPYTLNTFDEHLDMVM
VCHHLNPRIPEDVAFAESRIRRETIAAEDVLHDLGAISAMGSDSQGMGRIGETIARTWQLASHMRATRGPLPGDEGTGAD
NARILRYVAKLTINPARLFGIDHEVGSLEPGKLADIVLWEPKFFGIRPEVVFKGGFPAWSVMGEANASLMTCEPLRYRPQ
WAAFGRAPADVSVNFVAGAAIDAGLGQQLGLDTRLVACRGARALTKADLLHNDHLPDIRIEPDTYRVTVDGQPCVSTPMT
EVPLGRRYTLK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 2e-125 56
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 2e-125 56
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 9e-132 54
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-131 54
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 9e-132 54
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 9e-132 54

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mspyr1_10670 YP_004075587.1 urease subunit alpha VFG0270 Protein 2e-126 55