Gene Information

Name : FraEuI1c_4534 (FraEuI1c_4534)
Accession : YP_004018397.1
Strain : Frankia sp. EuI1c
Genome accession: NC_014666
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 5560239 - 5561906 bp
Length : 1668 bp
Strand : -
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: fal:FRAAL4159 2,3-dihydroxybenzoate-AMP ligase

DNA sequence : 
GTGAGCGCGCCGCTGGTCACCGAGACCGCTGCCGGCTCGACCGCGGCGGCGGGCTGGGTTCCCTGGCCGGACGAGGCCGC
CGACCGCTACGTGGCGGAGGGCTACTGGCGGGGCGGTTCGCTCGGCGAGCGGCTGCGCGGCTGGGCCGAGCGGTACGCCA
CCGCCACCGCCCTCGTCGCCGGTCCGGTCCGGCTCTCCTACGCGGATCTCGACCGGGCGGCGGACGACCTGGCGGCCGGG
CTCGCCGGGACCGGCCTCACCGTCGGTGACCGCGTCGTGGTCCACCTGCCCAACCGGGCCGAGTTCGTCACGCTGCTGTT
CGCGCTCTGCCGGCTGGGCGCGATCCCGGTGCTCACCCTGCCCGCGCACCGCCGGGTCGAGATCGAGCACCTGACCCGGC
TGTCCGGCGCGGTGGCCTACGCGATCCCGGATACGCACGAGGGCTTCGACCATCGGGTGTTGGCCCAGGAGATCGTCACC
GCGGTCCCGTCCGTCCGCCAGGTGCTGGTGGCCGGGGCTCCGGGCCCGTTCACCAGCCTGGAGGCGCTGGCCGCGGCGGG
AGCGGCCGCCCGGGCCGACGGCACGGCGCGGCCGGTGCCGGCGGCGCCAGACCCGGCCGGCGTCGCGGTGCTGCTCATCT
CGGGCGGCACCACCGGCAAGCCCAAGCTGATCCCGCGCACCCACTGGGACTACGGCTACAACGCCGAGGCCAGCGCCCGG
CTGTGCGGGCTGACCGCCGCGGACACCTACCTGGTCGCGCTGCCAGCCGCGCACAACTTCCCGTTGGCCTGCCCGGGGAT
CCTGGGGGCGCTCGGCGTCGGCGCGACCGTGGTCCTGGCTGCCTCGCCGAGCCCGGAGACCGCCTTCGGCCTGATCGGCG
GCGAACGGGTGACGGTGACGGCCCTGGTGCCGGCGCTCGCCCGGATCTGGGTCGACGCCGCCGAGTGGGAGCGGCCCGAC
ACGTCGAGCCTGCGCCTGCTGCAGGTCGGCGGCGCCCGGCTCGACGCCGAGCTGGCCCGGCGCATCCCGCGGGCGTTGGG
CGCCCAGGTCCAGCAGGTCTTCGGCATGGCCGAGGGGCTGCTGAACTACACCCGCCTCGACGAGGACGACGAGCTGGCCT
TCACCACCCAGGGACGGCCGCTCGCCGCCGCCGACGAGATCCGGGTCGTCGGCCCCGACGGCGCCGACGTGCCGGCCGGG
GCCGTCGGCGAGCTGTGGGCCCGCGGCCCCTACACGATCCGCGGCTACTACCGGGCCGCCGAGCACAACGCCACGGCCTT
CTCCCCGGACGGCTTCTACCGCAGCGGCGACCTCGTCCGGCTCACCCCGAGCGGCAACCTGGTCGTCGAGGGGCGCATCA
AGGACGTCGTCAACCGCGGCGGCGAGAACGTCTCCGCGACAGAGCTCGAGGAGCACCTGCTCGCGCACCCGTCGATCGCC
CAGGCCGCCGTCATCGCCGCGCCCGACGAGCAGGTCGGCGAGAGCGTCCGCGCGGTGATCGTCCCGGTCCCCGGGGCGGC
GCCGACCCTCAAGGCGGTCAAGGCCTTTCTGCGCGAGCGGGGGCTCGCCCGCTTCATGCTCCCCGACCTGCTGACGGTGC
TCGACGCGCTGCCGCTCACCCCCGTCGGAAAGATCGACAAGCGGGAGCTGCGGCGCCGCCTCGGCTAG

Protein sequence : 
MSAPLVTETAAGSTAAAGWVPWPDEAADRYVAEGYWRGGSLGERLRGWAERYATATALVAGPVRLSYADLDRAADDLAAG
LAGTGLTVGDRVVVHLPNRAEFVTLLFALCRLGAIPVLTLPAHRRVEIEHLTRLSGAVAYAIPDTHEGFDHRVLAQEIVT
AVPSVRQVLVAGAPGPFTSLEALAAAGAAARADGTARPVPAAPDPAGVAVLLISGGTTGKPKLIPRTHWDYGYNAEASAR
LCGLTAADTYLVALPAAHNFPLACPGILGALGVGATVVLAASPSPETAFGLIGGERVTVTALVPALARIWVDAAEWERPD
TSSLRLLQVGGARLDAELARRIPRALGAQVQQVFGMAEGLLNYTRLDEDDELAFTTQGRPLAAADEIRVVGPDGADVPAG
AVGELWARGPYTIRGYYRAAEHNATAFSPDGFYRSGDLVRLTPSGNLVVEGRIKDVVNRGGENVSATELEEHLLAHPSIA
QAAVIAAPDEQVGESVRAVIVPVPGAAPTLKAVKAFLRERGLARFMLPDLLTVLDALPLTPVGKIDKRELRRRLG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE CAA21394.1 - Virulence HPI Protein 5e-96 49
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-94 49
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 4e-96 49
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-94 49
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 6e-96 49
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-96 49
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 5e-96 49
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-96 49
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-96 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
FraEuI1c_4534 YP_004018397.1 AMP-dependent synthetase and ligase VFG1817 Protein 2e-107 52
FraEuI1c_4534 YP_004018397.1 AMP-dependent synthetase and ligase VFG0168 Protein 3e-99 48
FraEuI1c_4534 YP_004018397.1 AMP-dependent synthetase and ligase VFG0932 Protein 1e-81 43