Gene Information

Name : tkt (HMPREF0421_20791)
Accession : YP_003985896.1
Strain : Gardnerella vaginalis ATCC 14019
Genome accession: NC_014644
Putative virulence/resistance : Unknown
Product : transketolase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0021
EC number : 2.2.1.1
Position : 966294 - 968450 bp
Length : 2157 bp
Strand : -
Note : COG: COG0021; Pfam: PF00456,PF02779,PF02780; InterPro: IPR005478

DNA sequence :
ATGGCCAGCGTAAGCTGTGCGCAAAAAACCCGAATTATTGGAAGGAAAGTAGATCACATGACCGAATTCAACTGGTCTGC
ATTAGACGAGCGCGCCGTAAAGATGGCGAAGGTTCTCTCGGCTGATGCTGTTGAGCGAGCAGGACACGGACATCCTGGCT
CCCCTGTTTCATTGGCACCGATTGCGTACACCTTGTACCAGCACTTCATTAAGCACGATCCAGCTGACCCAAAGTGGGCC
GGTCGCGATCGTTTTATTCTTTCTGGCGGCCACGCTTCGCTTACGCAATATGTGCAGCTGTTCTTCTCTGGATACGGCTT
GACTCTTGATGATCTCAAGTATTTCCGTGGCGGCGCAGACACGCGTACTCCAGGTCACCCAGAATATGGCTTAACTCCAG
GCATTGAAATGACCACTGGTCCTCTTGGACAGGGTCTTGCTTCTGCTGTTGGTTTCGCTTATGGTCAGCGTTTTGAGCGT
GGTCTTCTTGATCCAGAAGCTCCAGCTGGCACTTCCCCATTCGATCACAAGGTTTGGGTTATCTGCGGCGAAGGCGACGT
TGAGGAAGGTGTTTCTTCCGAGGCTGCTTCCTTGGCTGGAAACCAAAAGCTTGGTAATTTGACTGTAATCTTCGATGCAA
ACCACATTCAGATCGAAGGCGACACTAAGCTCACCTTCTCCGAGGATATTCTTGCTCGTTACCGTGCATACGGTTGGTAC
ACCGACGAAGTTAGCTTCATTCAGCCAGACGGCTCCTACAAGGAAGACGTTCAGGCTTTGGCTGCAGCTATTGAAAAGGC
TCAGGAAGTTACCGATAAGCCTCACTTCATTAAGGTTAATACTTTGATTGCTTGGCCAACCCCAGGCAAGACCAACAATG
AAGCTTCTCACGGCTCTAAGCTTGGTGAAGAAGCTGTTAAGGGTTTGAAGGAACTTTGCGGTTTCGACCCAGAAGTTTCG
TTCCCAATCGACGAAGAAGCTTTGGCTCATGCTCGTAAGGTTGCTGAACGCGGTTTGGCTGCTCACAAGGCTTGGGATGA
AGCTCTTGCAAAGTGGGCTGCTCAAAACCCAGATAAGGCTGCTCTATACGAGCGCCTTAAGGCTGGCAAGCTTCCTGAAG
GCTTCGACAAGACTATCGACGACTTGGTTGCTGGTTTCGAAGTCGGTTCCAAGGTGGCTACCCGTAAGGCTTCTGGCGCA
GTTCTTAACGCAATTGCTGCTGTTATGCCAGAACTTTGGGGCGGCTCCGCTGATTTGGGCGGCTCCAACAACACCAACAT
TAAGGGCGCTGACTCCTTCGGTACATCCGAGGATGCAACTCGTACTTGGCCAAATGTTTCCGAGTACGGCCGCCAGCTTC
ACTTCGGTGTGCGCGAGTTCGCAATGGGTGCTATTACCAACGGTATTTTGCTTGGTTCTGACACTCGCCCATTCAACGGC
ACATTCTTCCAGTTCTCTGACTACGAGCGCCCAGCAGTTCGCTTGGCTGCTTTGATGGAGATTCCAAACCTCTACGTTTG
GACTCACGACTCCGTAGCCTTGGGCGAAGATGGTCCAACTCACCAGCCAATCGAGCACTTGGCTGCTTTCCGCGCTATTC
CTCAGCTTGAGGTTGTACGCCCTGCAGATGAGTATGAGACTGCTGAAGCTTACCGCTACTTCTTCGAGAAGAAGAACAAC
TACCCAACCGCTATGATTTTGACACGTCAAGGCGTACCAACCCTCGCAGAAACTGCTGAGAAGGCTCGCGAAGGCGTAAA
GCACGGCGGTTATGTGTTGGTTGACTGCGAAGGCACTCCAGACGTAATCATCATGGCTACTGGTTCTGAAGTTCAGTGGG
CTGTTGCTGGCGCCAAGACTTTGGCAGCAGAAGGCATTAAGGCTCGCGTTCTTTCTATGCCATCTCTCGAGTGGTTCGAA
GAGCAAGACGAAGAGTACAAGGAAGCAATCCTTCCAAAGTCCGTCAAGGCTCGCGTTTCCATCGAAGCTGGTTTGGCATT
GCCTTGGTACAAGTATCTTGGCGATTGCGGCAAGGCTGTTTCTATCGAACAGTACGGCTTGCAGGGTGACGGCGGTCAGA
ACATGATCGATTTGGGCATTACTGCTGAGCACGTAGTAGAAGCTGCTAAGGCTTCTATCGAAGAAGCACGCGCTTAA

Protein sequence :
MASVSCAQKTRIIGRKVDHMTEFNWSALDERAVKMAKVLSADAVERAGHGHPGSPVSLAPIAYTLYQHFIKHDPADPKWA
GRDRFILSGGHASLTQYVQLFFSGYGLTLDDLKYFRGGADTRTPGHPEYGLTPGIEMTTGPLGQGLASAVGFAYGQRFER
GLLDPEAPAGTSPFDHKVWVICGEGDVEEGVSSEAASLAGNQKLGNLTVIFDANHIQIEGDTKLTFSEDILARYRAYGWY
TDEVSFIQPDGSYKEDVQALAAAIEKAQEVTDKPHFIKVNTLIAWPTPGKTNNEASHGSKLGEEAVKGLKELCGFDPEVS
FPIDEEALAHARKVAERGLAAHKAWDEALAKWAAQNPDKAALYERLKAGKLPEGFDKTIDDLVAGFEVGSKVATRKASGA
VLNAIAAVMPELWGGSADLGGSNNTNIKGADSFGTSEDATRTWPNVSEYGRQLHFGVREFAMGAITNGILLGSDTRPFNG
TFFQFSDYERPAVRLAALMEIPNLYVWTHDSVALGEDGPTHQPIEHLAAFRAIPQLEVVRPADEYETAEAYRYFFEKKNN
YPTAMILTRQGVPTLAETAEKAREGVKHGGYVLVDCEGTPDVIIMATGSEVQWAVAGAKTLAAEGIKARVLSMPSLEWFE
EQDEEYKEAILPKSVKARVSIEAGLALPWYKYLGDCGKAVSIEQYGLQGDGGQNMIDLGITAEHVVEAAKASIEEARA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
APECO1_2641 YP_859417.1 transketolase Not tested Not named Protein 9e-105 41
tktA AAO17218.1 TktA Not tested tcd island Protein 2e-105 41