Gene Information

Name : clpC (HMPREF0421_20663)
Accession : YP_003985768.1
Strain : Gardnerella vaginalis ATCC 14019
Genome accession: NC_014644
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease ATP-binding subunit ClpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 818696 - 821185 bp
Length : 2490 bp
Strand : +
Note : COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593

DNA sequence :
ATGTTTGAACGGTTCACTGACCGCGCTCGGCGTGTGATTGTGCTAGCTCAGGAAGAAGCGCGCTCTCTTCAGCATAACTA
TATTGGTACCGAGCATATTCTCTTAGGTCTTATTAGAGAAGGCGAAGGAATAGCAGCAAAAGCTTTAAACGCCAAAGGCG
TAGAATTAGACAATACTCGTAAACAAATAAAAGAAATGATTGGCACTGGTACTGTCTCGCCTAGTGGACACATACCTTTT
ACTCCGCATGCTAAACAAGTGCTTGAGCTTAGTTTGCGTGAAGCATTGCAATTGGGGCACAGCTATATTGGTACCGAGCA
TATTCTCTTAGGTCTTATTAGAGAAGGCGAAGGTGTTGGAACGCAGGTGCTTATTAAGATGGAGGTCGATTTAGGAGATC
TTCGTAGCACTGCAATGGATTTGATTCGAGGAAATTCTGGATTACCAGAAGACGGTCAGAAGGGTGATTTGGCTAATGCT
GGAGGAGTGCAGGATAAGAGGAATCAGTCTGGTTCTGCGCTGCTAGATCAGTTCGGAAGGAATCTTACTACAGAAGCTGA
GCAAGGGAAGCTTGATCCTGTTATTGGTCGTTCAAAAGAGATTGAGCGCGTTATGGTTGTGCTTTCTCGCAGAACTAAGA
ATAATCCTGTTCTTATAGGTGAACCTGGTGTTGGTAAAACAGCTGTTGTGGAAGGTCTTGCACAGAAGATTGTTGCTGGA
GATGTGCCAGAAACGTTAAAGGGCAAGCAGGTTTATTCTCTTGACTTGGGTTCGATGGTTGCTGGATCTCGTTATCGTGG
CGATTTTGAAGAGCGCTTAAAGAAGGTGCTTAAAGAAATTAAGACTCGTGGAGATATAGTTCTATTTATTGATGAGATTC
ATACTATTGTTGGTGCTGGGTCTGCAGATGGTGCTTTGGGTGCTTCTGACATGCTTAAACCTATGCTTGCGCGTGGTGAG
CTACAGACGATTGGTGCTACAACTACCGATGAGTATAGAAAGTATATTGAAAAGGATGCGGCTTTGGAAAGAAGATTCCA
GCCTATTCAAGTTCAAGAGCCTTCTATTGCAGAGACAATTGAGATTCTAAAAGGTTTGCGTGCACGCTACGAGAATCATC
ATCACGTAACTATTACGGATGCTGCTTTGCAGTCTGCAGCCGAAATGTCTGCTCGCTATATTCAAGATAGGAATTTGCCA
GATAAGGCGATTGATCTTATTGATGAAGCTGGAGCTCGCCTACGTATTAAGCGATTGACAGAGCCACCAGAGCTTAAGGA
ACTTGATTCTAAGATTTCTAAACTTTCAGAAAAGAAAGATGAAGCTATTAAGAATCAGGACTTTGAGAAGGCTGCCGACT
TGCGAGATGAGCAGGAAAAGCTTGAGGAAGAACGTAAGAATAAAGAGCAGGCTTGGCGTGAGGGCGAGTCTAATGTGAAT
ATGGTTGTAGACGAGGATGTTATTGCATCTGTTGTTTCTAATACAACTGGTATTCCTGTTGTTAAGCTAACTCAAGCGGA
ATCCAAAAAGTTGCTCGGTATGGAAGCGGAGCTTCATAAGCGTATTATTGGTCAAGATGAGGCTGTTTCTGCACTTTCTC
GTTCTATTCGTCGTGCGCGAGTAGGATTGAAAGATCCAAAGCGTCCTTCTGGATCGTTTATTTTCGCTGGTCCTACGGGA
GTTGGTAAGACAGAGCTTGCTAAAACCTTGGCTCAATTCCTGTTCGACGATGATGATGCTTTGATTCGTGTTGATATGTC
GGAGTTTGCGGAAAAGTATGCGGCTTCTCGTCTTTTCGGTGCTCCTCCAGGATATGTTGGCTACGAGGAGGGTGGCGAGC
TTACAGAGAAGGTTCGTAGAAAGCCATTCTCGGTGGTGCTTTTTGACGAAATTGAAAAGGCTCATCCAGATATTTTCAAC
ACGCTTTTGCAAGTGTTAGACGACGGTCATTTAACAGATGGCCAAGGAAGAAAAGTTGATTTTAAGAACACGATTATTAT
CTTGACTACAAATCTTGGTACTCGTGATATTGCTAAGTCAGCGAATACTGGTTTTAGTCTTGGCAATAATGCGGATGCAT
CTTACCAGAGGATGAAGGATCAGGTTAATTCGGAATTGAAGCGTCAGTTCCGTCCGGAATTCCTAAACCGTTTGGATGAT
ACGATTGTATTCCGTCAGCTTACTGAGCCAGAGGTTCGTCAGATTGTTGATTTGGACGTTAAGCGTTTGAATGACCGTCT
GTTTGAACGTCATATGACTTTGGAGCTTACAGATGCAGCTAAGAATCTTCTTGCGCAAAAGGGCTTTGATCCTCTTCTTG
GAGCAAGACCGTTGCGAAGAGTTATTCAGCGCGATATTGAGGATGCCATAAGTGAGAAGATTTTGCTTGGCGACTTAACA
GATGGTGAACGCGTTGAAGTTGATGCAGAAGGAGAAGGTTTGCTGGGGGAGTTTATTTTCCGCGGCATAAAGTTTGATGT
TGAGTCTTGA

Protein sequence :
MFERFTDRARRVIVLAQEEARSLQHNYIGTEHILLGLIREGEGIAAKALNAKGVELDNTRKQIKEMIGTGTVSPSGHIPF
TPHAKQVLELSLREALQLGHSYIGTEHILLGLIREGEGVGTQVLIKMEVDLGDLRSTAMDLIRGNSGLPEDGQKGDLANA
GGVQDKRNQSGSALLDQFGRNLTTEAEQGKLDPVIGRSKEIERVMVVLSRRTKNNPVLIGEPGVGKTAVVEGLAQKIVAG
DVPETLKGKQVYSLDLGSMVAGSRYRGDFEERLKKVLKEIKTRGDIVLFIDEIHTIVGAGSADGALGASDMLKPMLARGE
LQTIGATTTDEYRKYIEKDAALERRFQPIQVQEPSIAETIEILKGLRARYENHHHVTITDAALQSAAEMSARYIQDRNLP
DKAIDLIDEAGARLRIKRLTEPPELKELDSKISKLSEKKDEAIKNQDFEKAADLRDEQEKLEEERKNKEQAWREGESNVN
MVVDEDVIASVVSNTTGIPVVKLTQAESKKLLGMEAELHKRIIGQDEAVSALSRSIRRARVGLKDPKRPSGSFIFAGPTG
VGKTELAKTLAQFLFDDDDALIRVDMSEFAEKYAASRLFGAPPGYVGYEEGGELTEKVRRKPFSVVLFDEIEKAHPDIFN
TLLQVLDDGHLTDGQGRKVDFKNTIIILTTNLGTRDIAKSANTGFSLGNNADASYQRMKDQVNSELKRQFRPEFLNRLDD
TIVFRQLTEPEVRQIVDLDVKRLNDRLFERHMTLELTDAAKNLLAQKGFDPLLGARPLRRVIQRDIEDAISEKILLGDLT
DGERVEVDAEGEGLLGEFIFRGIKFDVES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 67

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_003985768.1 ATP-dependent Clp protease ATP-binding subunit ClpC VFG0079 Protein 0.0 56
clpC YP_003985768.1 ATP-dependent Clp protease ATP-binding subunit ClpC VFG0080 Protein 1e-142 51