Gene Information

Name : pfo (HMPREF0421_20066)
Accession : YP_003985175.1
Strain : Gardnerella vaginalis ATCC 14019
Genome accession: NC_014644
Putative virulence/resistance : Virulence
Product : perfringolysin O
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 66002 - 67627 bp
Length : 1626 bp
Strand : +
Note : Pfam: PF01289; InterPro: IPR001869

DNA sequence :
ATGCCATGCATAGAAGCAAATAAGTTACGGTATCTCATAAAAAATAACAGAAAATATCATAATATAAGGATACATATGAA
GAGTACAAAGTTCTACCGTAATGCAGCAATGTTGCTCCTCGCGGGCGCAACTATTGTTCCACAATGCTTAGCAGCACCAG
CAATGGCCGCTCCTTCCGCTAAGGATTCTGAACCAGCTACATCTTGCGCAGCTAAGAAAGACTCGTTGAATAATTATTTG
TGGGATTTGCAATACGATAAAACAAACATTCTCGCCCGTCATGGCGAAACCATTGAGAACAAATTCTCCAGCGACAGCTT
CAACAAGAACGGTGAATTCGTTGTTGTTGAGCATCAGAAGAAGAACATCACCAATACAACTTCAAATTTGTCGGTTACTT
CCGCCAACGATGATCGCGTATACCCAGGTGCTCTTTTCCGTGCTGATAAGAATTTGATGGACAATATGCCAAGCCTGATT
TCTGCAAACCGCGCTCCAATAACGTTGAGCGTTGATTTGCCGGGATTCCACGGCGGCGAAAGTGCTGTAACTGTTCAGCG
CCCAACCAAGAGCTCTGTAACTTCCGCAGTGAACGGCTTAGTTTCTAAGTGGAATGCACAATATGGAGCAAGTCATCATG
TTGCAGCTCGCATGCAGTACGATTCTGCAAGCGCACAAAGCATGAACCAGCTCAAGGCTAAGTTTGGTGCTGATTTTGCC
AAGATTGGTGTTCCGCTGAAGATTGATTTCGATGCAGTACACAAGGGTGAGAAGCAGACTCAAATTGTGAACTTCAAGCA
AACTTACTACACCGTAAGCGTTGATGCACCAGATAGCCCAGCAGATTTCTTTGCTCCTTGCACTACGCCAGACAGCTTGA
AGAACCGTGGCGTTGACAACAAGCGCCCACCAGTTTACGTGTCAAACGTAGCTTATGGTCGCTCAATGTACGTAAAGTTC
GATACCACCAGCAAGAGCACTGATTTCCAGGCTGCGGTAGAAGCAGCAATTAAGGGCGTAGAAATCAAGCCAAACACCGA
ATTCCATCGCATTCTCCAGAATACTTCTGTTACTGCAGTGATTCTTGGTGGCAGCGCTAATGGTGCAGCTAAAGTTATTA
CAGGCAATATCGATACGCTTAAGGCTTTGATTCAGGAAGGTGCAAATTTGAGCACCTCTAGCCCAGCGGTTCCAATTGCA
TACACCACTTCCTTCGTCAAGGATAACGAAGTAGCAACTTTGCAATCCAACAGCGATTATATTGAAACGAAGGTTTCTTC
TTATCGCAATGGCTACTTGACTTTGGACCACCGTGGAGCTTATGTAGCTCGCTACTACATCTACTGGGATGAGTACGGCA
CCGAAATTGACGGCACTCCTTACGTGCGTTCTCGCGCTTGGGAAGGCAATGGTAAGTATCGTACAGCTCACTTCAACACC
ACTATTCAGTTCAAAGGAAATGTACGCAATCTACGAATCAAGTTGGTTGAAAAGACTGGTTTGGTTTGGGAACCATGGCG
CACAGTATATGACCGTTCTGATTTGCCACTAGTTCGTCAGCGTACTATTAGCAACTGGGGCACAACCTTGTGGCCTCGCG
TTGCTGAAACTGTAAAGAACGACTGA

Protein sequence :
MPCIEANKLRYLIKNNRKYHNIRIHMKSTKFYRNAAMLLLAGATIVPQCLAAPAMAAPSAKDSEPATSCAAKKDSLNNYL
WDLQYDKTNILARHGETIENKFSSDSFNKNGEFVVVEHQKKNITNTTSNLSVTSANDDRVYPGALFRADKNLMDNMPSLI
SANRAPITLSVDLPGFHGGESAVTVQRPTKSSVTSAVNGLVSKWNAQYGASHHVAARMQYDSASAQSMNQLKAKFGADFA
KIGVPLKIDFDAVHKGEKQTQIVNFKQTYYTVSVDAPDSPADFFAPCTTPDSLKNRGVDNKRPPVYVSNVAYGRSMYVKF
DTTSKSTDFQAAVEAAIKGVEIKPNTEFHRILQNTSVTAVILGGSANGAAKVITGNIDTLKALIQEGANLSTSSPAVPIA
YTTSFVKDNEVATLQSNSDYIETKVSSYRNGYLTLDHRGAYVARYYIYWDEYGTEIDGTPYVRSRAWEGNGKYRTAHFNT
TIQFKGNVRNLRIKLVEKTGLVWEPWRTVYDRSDLPLVRQRTISNWGTTLWPRVAETVKND

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hly AAA69525.1 listeriolysin O Virulence LIPI-1 Protein 2e-96 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pfo YP_003985175.1 perfringolysin O VFG1363 Protein 1e-128 53
pfo YP_003985175.1 perfringolysin O VFG2275 Protein 3e-90 42
pfo YP_003985175.1 perfringolysin O VFG0074 Protein 2e-96 41