Gene Information

Name : lysS2 (HMPREF0733_10955)
Accession : YP_003983846.1
Strain : Rothia dentocariosa ATCC 17931
Genome accession: NC_014643
Putative virulence/resistance : Unknown
Product : lysine--tRNA ligase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 1009759 - 1013091 bp
Length : 3333 bp
Strand : -
Note : COG: COG1190; Pfam: PF04329,PF04330,PF04331,PF01336,PF00152; InterPro: IPR002313

DNA sequence :
ATGTACCGAGTGATTGGTGGAGAACGGTTTATGGCACATCAGAAACAGGGCACAGAAGCCCATCACACGACATCACGCTA
TGCGGAAATCATCGCCCGCTGGGTTATCGGTATCTACTCAATCGCAACAATTCTGACGCTTTTCACCTGGATTATTTCCC
CGCTTCGCAGGGGCCACGGGTTCACCTGGTGGGAAATCACCGCGAGCCTGCTCAACATCCCATCAAGTCATACGCTGGTG
AGCGCAGTCATCATGGTGGTCATGACGTCCGCCCTGATCACCCGTAAACGGGCCGCCCTCTACGCCGTCATTTTCTTTCA
AGTCATCGGCATCCTCATCGGAACACGAAGCGCGCTTCTGCTCTTCTTCCCCGATAACGTGATGCCGAGCGAAGAATTTT
TCTCCTCCACGCTCGACACCGTGGCTATTATCGTGGCGGCTATCTTTATTCCGCTTCTCATCCTGGCACGCTCTGCTTTC
CCGGCGCATATAGGCCGAATTTCATGGGTATTGGCAACCGTGGTCTTCCTCGGCGGGCTAACGGTGACAACCCTGCTGGC
CTGGTATTTTGGGCATCACGTGCCGGGAGTTACGGTTCCCCACCTGCTCAAGCAGGGGTTAGGGCTCGATAGTTTTCCCG
AGCTCAAGGGTGCAAACCCGGGCGCCACGGTGGTGGGGGCAGCATCCGTGTTCTACGGAATTTTTGCACTGATCGCGGTG
TATGTGGTGGTGCGGGGGTACCGTGTCCCCAATACCTGGACCGCCGATCGGGAATTGCGCCTGCGCGAACTTTTACAGGA
GTATGGCGGGAACGATTCACTCTCGTACTTTGCAACACGCCGCGATAAACAGGTGATTTTCTCGGCGGATATGCGTGCCG
CTGTCACCTACAGGCAAGTGGGTTCGGTATGTTTGGCGTCCAGCGACCCGGTGGGCGATCCGGCGTCCTGGGGTTCCGCA
ATCGACCGGTGGATGTACCAGGTGCGCCGCTACGGGTGGATTCCCGCCGCCATCAGCGTGAGCGAAGACGGCGCCAGAGC
CTTCGCACGCCGGGGACTGGGCATAATCCGCATGGGGGACGAAGCCATTCTAGAGGTCTCACGTTTTAGCCTGAACAATA
CTTCGCTTACGGAGGTACGCCACGCCCACCAGCGGGTTCGTAAGGCCGGTTACACACTGAAAATCTGCAGGCATCGTGAG
CTTTCACCCGAGCAGCTGCACGAGGTGGAAAATAACGTGAACGCTTGGCGTCACGGCAAGGTTGAGCGCGGGTTCTCGAT
GGCGCTCAACAGGCTCTCAGACCCCGCAGACGGTCGCAATCTGCTTGTTTCGGCGCATGATTCTGCTGGCACAATGGTTG
CCCTCCTCTCATTCGTGCCGTGGGGCCGCACCGGCATATCGCTGGATGTGATGCGCCGCTCCCCCGACAGCCCCAACGGC
ATCGTGGAATATATGGTTGCCCAGCTTATGGAGGATGCCCCCGACTACGGCATCACGCGTGTTTCACTGAACTTTGCTAT
GTTCCGCCATGTGTATGAGAACGCAGATCAGTTCGGCGCTAATGCCTGGAGCAGGTTCGCCTCTCGGTCACTGGGGGTTT
TAGACAGGTTCCTTCAGTTGGAGAGACTGTACCGCTTCAACCTCAAGTTCGCCCCGGAGTGGATGCCGCGCTATATGGTT
GCGGAACCGACGCTGGCTTTCCTGAACGTTGCGGCGGCGGCCGGGGTTGCCGAGGGCTTCCTGCCTGATTTTTCGGCACG
TAAACAGCGCCATGAAGTGCACCGCCTGACCGAAGACCAGATCGCGCGAGTGCACGAGATCGAGCGTATGCATCCGGGTG
AGGCGCAGGCCCCCGAACACCGCTTCAGCGATCAGACCAAGCACCGTATTCGTCACCTGCAGATGCTTCGTGATGTCGGC
ATGAACCCGTACCCGCTGGGAGTCACGTGCGAGTATTCGACGGTGCAGGTGCACGATGGGCTGAGCGGCCATACGCTTCC
GAGCAGGGAGTTTACCCTATCGGGCAGGGTGCGGTTTATTCGCAACCACGGCGGGGTTATCTTCCTGACCCTGTCTGAGG
AAGGCAAACAGGTACAGATTATTGCCGAGCGCAGCCTTGTGAGTGAGCGCGAGTTTCGGCTTCTCAAGTCCGCTGTCGAT
ACGGGTGATATTCTGCTCGTGACCGGCACGGCGGGGACTAGCCGCACCGGAACCGCATCCGTCATTGTGCATAGCTGGCA
GATGGCGGCGAAGTGTCTGCACCCCATTCCGTACGGAGCGTTGAATGATCCGGAGGCGCGCATCCGCAAACGCTCGACCG
ACCTGTTGGTGCATCCGCAGCAGCTTGAAAACCTTCGGATGCGCTCCTCACTGATCACTGCCATTCGCCGCACGCTTGAT
GATGCAGGGTTCACCGAGGTTGAGACCCCGATTCTGAATACTATTCATGGCGGTGCGAGCGCGCGCCCCTTCAAAACCTT
TATCAACGCCTATGGTGCGGATTTGACGCTTCGCATTGCGCCCGAGCTGTATCTTAAGCGCCTGGTGGTTGGCGGTTTGG
GCGCGGTTTATGAGTTAGGGCGGGATTTTCGCAACGAAGGCGCGGATGCCACCCATAACCCGGAGTTCACGGTGTTGGAG
GCTTATAAGCCTTACGCAGATTACACGGTCATGCGCAAGCTTACTGAAACGCTCATCAAGAATGCCGCCCGGGCCGTCTA
TGGTTCTGAGGTACTTCCGCTGGGCGAGAAGGGCAGTACCGAGCGTACTCTCACGGATGTTTCGGGTGAGTGGCGGGCAG
TTTCGGTATGCGAGGCCCTTTCGCGTGCGCTGGGGCGCGATATTTCGAGTGAAACAGATTTTGAGACTTTGCTTGAGCTG
GCACATGAGCATCAGATTCATGTGCGTGATGACATGGGCGCGGGCGCCATTCTTGAGGAGCTTTACGGCGAGCTGGTTGA
GGCGAAGACCGTGTTCCCCACGTTTTATACGGATTTTCCGGTGGAGACCTCTCCCCTGGCGGGTGCGCATCGCAGCGAGC
CGCATCTGGTGGAACGCTGGGATTTGGTGATTAACGGTATGGAGATGGGAACCGCCTATTCCGAGATGACGGATGCTTTA
GAACAGCGCCGCCGCCTGACCGAGCAGTCTCTCAAGGCCGCGGCGGGAGACCCGGAAGCCATGCAGATTGATGAGGATTT
TCTGTACGCCCTTGAGACCGGGCTTGTCCCGACGGGCGGGTTGGGCATCGGCATTGACCGTTTGGCGATGCTCATGGCAC
AGACCCAGATTCGCGGGGTGCTTTCTTTCCCGTTTGTTAAACCCGTGAAGTAG

Protein sequence :
MYRVIGGERFMAHQKQGTEAHHTTSRYAEIIARWVIGIYSIATILTLFTWIISPLRRGHGFTWWEITASLLNIPSSHTLV
SAVIMVVMTSALITRKRAALYAVIFFQVIGILIGTRSALLLFFPDNVMPSEEFFSSTLDTVAIIVAAIFIPLLILARSAF
PAHIGRISWVLATVVFLGGLTVTTLLAWYFGHHVPGVTVPHLLKQGLGLDSFPELKGANPGATVVGAASVFYGIFALIAV
YVVVRGYRVPNTWTADRELRLRELLQEYGGNDSLSYFATRRDKQVIFSADMRAAVTYRQVGSVCLASSDPVGDPASWGSA
IDRWMYQVRRYGWIPAAISVSEDGARAFARRGLGIIRMGDEAILEVSRFSLNNTSLTEVRHAHQRVRKAGYTLKICRHRE
LSPEQLHEVENNVNAWRHGKVERGFSMALNRLSDPADGRNLLVSAHDSAGTMVALLSFVPWGRTGISLDVMRRSPDSPNG
IVEYMVAQLMEDAPDYGITRVSLNFAMFRHVYENADQFGANAWSRFASRSLGVLDRFLQLERLYRFNLKFAPEWMPRYMV
AEPTLAFLNVAAAAGVAEGFLPDFSARKQRHEVHRLTEDQIARVHEIERMHPGEAQAPEHRFSDQTKHRIRHLQMLRDVG
MNPYPLGVTCEYSTVQVHDGLSGHTLPSREFTLSGRVRFIRNHGGVIFLTLSEEGKQVQIIAERSLVSEREFRLLKSAVD
TGDILLVTGTAGTSRTGTASVIVHSWQMAAKCLHPIPYGALNDPEARIRKRSTDLLVHPQQLENLRMRSSLITAIRRTLD
DAGFTEVETPILNTIHGGASARPFKTFINAYGADLTLRIAPELYLKRLVVGGLGAVYELGRDFRNEGADATHNPEFTVLE
AYKPYADYTVMRKLTETLIKNAARAVYGSEVLPLGEKGSTERTLTDVSGEWRAVSVCEALSRALGRDISSETDFETLLEL
AHEHQIHVRDDMGAGAILEELYGELVEAKTVFPTFYTDFPVETSPLAGAHRSEPHLVERWDLVINGMEMGTAYSEMTDAL
EQRRRLTEQSLKAAAGDPEAMQIDEDFLYALETGLVPTGGLGIGIDRLAMLMAQTQIRGVLSFPFVKPVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lysS1 YP_005682181.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 3e-166 41
lysS1 YP_005684273.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 5e-167 41
lysX YP_003784331.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 5e-167 41
lysS1 YP_005686365.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 5e-167 41