Gene Information

Name : guaA (HMPREF0733_10234)
Accession : YP_003983126.1
Strain : Rothia dentocariosa ATCC 17931
Genome accession: NC_014643
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 252196 - 253788 bp
Length : 1593 bp
Strand : -
Note : COG: COG0519; Pfam: PF00117,PF03054,PF00958; InterPro: IPR001674

DNA sequence :
GTGACCGACTCTGTACACCCGGATCAGCTTGAAGAGCGTCCGGTTCTGGTGGTAGATTACGGTGCCCAGTATGCGCAGCT
TATCGCTCGTCGTGTGCGTGAGGCGGGTATCTACTCTGAAATCGTTCCCCACTCTATGAGCACCGAAAAGATGCTCGCTA
AAAACCCCGCCGCGATTGTGCTTTCGGGCGGGCCTTCATCGGTGTATGCCGATGGCGCCCCCCGTGGCGATAGGGCACTA
TTTGAGGCTGGCGTGCCGGTCTTCGGTATCTGCTACGGTTTTCAGGTGATGGCGCAAACCTTGGGCGGTACCGTGGCGCA
GACCGGTTCCCGCGAATACGGCGCAACCGATGCGACCCTGTGTGCAGTTGAGTCTTCGTTCCTCACTGGAACCCCGCAGA
CGCAAAACGTGTGGATGTCGCACGGCGATTCCGTGACCGAAGCCCCCGCCGGGTTTGAGGTTCTGGCGCAGACCCCGGGT
GCGTCCGTGGCGGCGTTCGTGGATGAGCACCGCAAGCTGGGCGGCGTGCAGTGGCATCCCGAGGTGAAGCACTCCGACTA
CGGTCAGGTTGCGCTTGAGAACTTCCTCTACAACATTGCCGGACTTAAACCCACCTGGTCAACCGACAATATTATTGAGG
AACAGGTTGCAAAGATTCGTGAGCAGGTTGGCGAAGACCGCGTGATTTGTGCGCTCTCTGGCGGCGTGGATTCTTCTGTT
GCCGCAGCCCTCGTGCATAAGGCTGTAGGCGATCAGCTGACCTGCTTCTTTATCGACCACGGGCTGCTGCGCGCGGGCGA
GCGTGAACAGGTTGAGCAAGACTACGCCGCGTCAATGGGTATTCGCGTAATTACCATTGACGAATCAGAGCGTTTCCTCA
CTGCACTGGCTGGCGTGAGCGACCCTGAGCAGAAGCGTAAGATTATTGGCCGCGAGTTCATCCGCTCCTTTGAGCAGGCC
GAGCGCAAGCTCATTGAGGAAGCGGGCGAAGAGGGCGCACAGATCAAGTTCCTGGTGCAGGGTACCCTGTACCCGGATGT
GGTTGAATCCGGCGGCGGCGAGGGTGCGGCGAATATTAAGTCGCATCACAATGTGGGTGGTTTGCCTGAGGATTTGGCGT
TTGAGCTGGTCGAGCCGCTGCGTACCCTGTTTAAGGATGAGGTTCGCGCGATTGGCCGTCAGCTGGGTGTTCCCGAGAAG
ATCGTGGCGCGCCAGCCGTTCCCCGGCCCCGGTCTGGGTATTCGTATTGTGGGTGAGGTGACCCGCGAGAACCTTGAGAC
CCTGCGCGCGGCGGATGCGATTGTGCGTGAAGAGCTGACCGCAGCCGGTCAGGACGAGCATATTTGGCAGTGCCCCGTGG
TTCTTCTCTCCGGTGTGCGTTCGGTGGGTGTGCAGGGCGATGGCCGCACTTATGGGCATCCGATTGTGCTGCGCCCGGTT
TCTTCGGAGGATGCGATGACCGCCGACTGGTCGCGTCTGCCCTATGATCTGCTGGCAAAAATCTCGAACCGGATTACGAA
CGAAGTCAAAGACGTGAACCGCGTGGTGCTGGATGTAACCTCTAAACCCCCGGGAACCATTGAGTGGGAGTAA

Protein sequence :
MTDSVHPDQLEERPVLVVDYGAQYAQLIARRVREAGIYSEIVPHSMSTEKMLAKNPAAIVLSGGPSSVYADGAPRGDRAL
FEAGVPVFGICYGFQVMAQTLGGTVAQTGSREYGATDATLCAVESSFLTGTPQTQNVWMSHGDSVTEAPAGFEVLAQTPG
ASVAAFVDEHRKLGGVQWHPEVKHSDYGQVALENFLYNIAGLKPTWSTDNIIEEQVAKIREQVGEDRVICALSGGVDSSV
AAALVHKAVGDQLTCFFIDHGLLRAGEREQVEQDYAASMGIRVITIDESERFLTALAGVSDPEQKRKIIGREFIRSFEQA
ERKLIEEAGEEGAQIKFLVQGTLYPDVVESGGGEGAANIKSHHNVGGLPEDLAFELVEPLRTLFKDEVRAIGRQLGVPEK
IVARQPFPGPGLGIRIVGEVTRENLETLRAADAIVREELTAAGQDEHIWQCPVVLLSGVRSVGVQGDGRTYGHPIVLRPV
SSEDAMTADWSRLPYDLLAKISNRITNEVKDVNRVVLDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-169 69
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-131 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-131 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-131 52