Gene Information

Name : aldA (HMPREF0733_11439)
Accession : YP_003984330.1
Strain : Rothia dentocariosa ATCC 17931
Genome accession: NC_014643
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.3
Position : 1577021 - 1578496 bp
Length : 1476 bp
Strand : -
Note : COG: COG1012; Pfam: PF00171; InterPro: IPR015590

DNA sequence :
ATGGCAAAAGATTTGAATGTGTTCGATAAAGAGTACGGTCTTTTGATTAACGGCGCGTGGACGAGCCCCGGCACGCTTTT
GGATTCTTACAATCCCGCCAACGGTGAAACACTGGCAAAATTTACCGACGCGTCCGACGCCGATGTCGATGCCGCCGTCG
CCGCCGCGCAGGAAGCGTTCAAAACATGGCGCAAGACCACCACAACCGAACGCGCCGCCATACTCAACAAAATCGCCGAT
GTGATTGACGAAAACTTGGAATTGTTCGCCTTGCAGGAAACGCTGGACAACGGCAAACCCATCCGCGAAACCCGCGCCGC
AGACATCCCGCTGGCTTCCGACCATTTCCGTTATTTCGCCAGCGTCATCCGCGGCGAAGAAGGCACCGCAACCCAACTTG
ACTCCGAAGACCTGTCCATCGTACTGCGCGAACCTATCGGCGTCGTCGGTCAGATTATTCCGTGGAACTTCCCCTTCCTG
ATGGCGGCTTGGAAAATCGCACCCGCACTTGCCGCAGGCTGCACCATCGTCATTCACCCGTCCTCCAGCACTTCGCTGAG
CCTGTTGTCGCTCGCCCAAAAAATTAACCACCTACTGCCTAAAGGCGTGCTGAACATCATCACCGGACGCGGTTCGAAAT
CCGGCGAATACATGCTGCACCACAAAGGCTTCAACAAACTCGCCTTCACCGGCTCAACCGAAATCGGCCGCCGCATCGGC
ATCGCTGCCGCCGAAATGCTCATTCCCTCTACCTTGGAGCTGGGCGGCAAATCCGCCAACATCTTCTTTGACGACATGCC
GTTCGACAAAGCCCTCGAAGGCGCACAAAAAGGCATTTTGTTCAACCAAGGCCAAGTGTGCTCCGCCGGTTCGCGCATCT
TCGTACAAGAAGGCATTTACGACAAATTCGTCAACGCCTTGGCGGAAGAGTTCAAAAAAATCAAAGTCGGACTGCCTTGG
GAAGACGATACCCAAATGGGTTCGCAAGTCAACGCCGGCCAGCTTGAAACCATTTTGAAATATGTCAAAATCGGTGAGCA
GGAAGGCTGCCGCATTATCACCGGCGGCAAAAAACTCGAAGGCGAATTGGGCAAAGGCGAATTTGTCGAGCCGACCTTGA
TCGAGGCTGACAACAACAACGCCCGCGTTGCCCAAGAAGAAATCTTCGGACCGGTTGCTACCGTGATTAAATTCAAAACC
GAAGAAGAAGTCGTCAAAATGGCCAACGACAGCGAATACGGCTTGGGCGGCGCAGTTTGGAGCAAAGACATCAACCGCTG
CCTGCGCGTCTCCAACGCGCTGGAAACCGGTCGTGTCTGGGTGAACTGCTACAACCGTCTGCCCGCAGGCGCACCGTTCG
GCGGCTACAAAACTTCAGGCATCGGCCGCGAAACCCACAAGATGATGCTCGCCGCCTACACGCAGGTGAAAAACATCTAC
ATTTCCACCCGCGAAGAGCGCGAAGGGTTATATTAA

Protein sequence :
MAKDLNVFDKEYGLLINGAWTSPGTLLDSYNPANGETLAKFTDASDADVDAAVAAAQEAFKTWRKTTTTERAAILNKIAD
VIDENLELFALQETLDNGKPIRETRAADIPLASDHFRYFASVIRGEEGTATQLDSEDLSIVLREPIGVVGQIIPWNFPFL
MAAWKIAPALAAGCTIVIHPSSSTSLSLLSLAQKINHLLPKGVLNIITGRGSKSGEYMLHHKGFNKLAFTGSTEIGRRIG
IAAAEMLIPSTLELGGKSANIFFDDMPFDKALEGAQKGILFNQGQVCSAGSRIFVQEGIYDKFVNALAEEFKKIKVGLPW
EDDTQMGSQVNAGQLETILKYVKIGEQEGCRIITGGKKLEGELGKGEFVEPTLIEADNNNARVAQEEIFGPVATVIKFKT
EEEVVKMANDSEYGLGGAVWSKDINRCLRVSNALETGRVWVNCYNRLPAGAPFGGYKTSGIGRETHKMMLAAYTQVKNIY
ISTREEREGLY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-97 52
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 1e-99 50
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 1e-99 50
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 1e-99 50
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-99 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
aldA YP_003984330.1 aldehyde dehydrogenase VFG0082 Protein 5e-98 52