Gene Information

Name : merA (AXYL_01070)
Accession : YP_003977131.1
Strain : Achromobacter xylosoxidans A8
Genome accession: NC_014640
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 1147314 - 1149002 bp
Length : 1689 bp
Strand : +
Note : -

DNA sequence : 
ATGGCCGAGGCGATCACCCTCCACATCGAAGGCATGACCTGCACGTCGTGCGCCGAGCACGTCCAGCAGGCTTTGACGAA
CGTGCCCGGCGTGCGCGCGGCCTCGGTGTCCTATCCGCAGCGGCAGGCCGAAATCGAGGCGGATGCAGGCGTGAGCGTGG
CCCCGCTGGTTGCCGCAGTGGCCACGCTCGGCTATCGCGCACGGCTTACCGACACGCCGAACAAGCCTGCCGGCCTGCTA
GACAAGGCGCTGGGCTGGCTCGGTGGCGAAACGAAGCATGTTGGCGGTGAACAAGCGCTGCACGTGGCTGTGATAGGCAG
CGGCGGCGCGGCGATGGCGGCTGCCTTGAAGGCCGTGGAGCAAGGCGCCCGCGTCACGCTGATCGAGCGCGGCACCATCG
GCGGCACCTGCGTCAATGTCGGCTGCGTGCCGTCCAAGATCATGATCCGCGCCGCGCACATCGTCCACCTGCGCCGCGAA
AGCCCGTTCGATGCTGGCCTGCCGGCCGCAGCGCCCGCTGTACTGCGCGAGCGGCTGCTGGCCCAGCAACAAGGCCGCGT
CGAGGAGCTGCGCCATGCCAAGTACGAAGGCATCCTGGCAAGCACTCCGGCCATCACCGTGCTGCGCGGCGAGGCCCGGT
TCAGGGACACGCGCACGCTGACCGTGGCGACCGCTGACGGCGGCACGCACGAGGTGAACTTCGACCGCTGCCTGATTGCC
ACCGGCGCGAGCCCGGCGCTTCCGCCAATCCCGGGCCTTGCGGACACACCCCACTGGACCTCCACCGAGGCGCTGGAAAG
CAGCTCGCTCCCCGAGCGGCTGGCCGTGATTGGTTCCTCCGTGGTGGCGGTCGAGTTGGCGCAAGCCTTCGCCCGGCTGG
GCAGCCAGGTCACGATCCTGGCGCGCAGCACGCTGTTCTTCCGAGAAGACCCGGCCATCGGGGAAGCCGTAACAGACGCC
TTCCGCGCCGAGGGCATCGAGGTGCTGGACCACACCCAGGCGAGCCACGTTGCCTATGCGGGCGGGGAATTCGTGCTCAC
CACCGGGCAGGGGGAAGTGCGCGCCGACAAGCTGCTGGTCGCCACCGGTCGCGCGCCGAACACGCGCAGCCTGAACCTTG
AAGCGGCAGGCGTCGAAGTCAATGCGCAGGGAGCCATCGTCATCGACCGCGCCATGCGCACGAGCGCACCGCACATCTTT
GCTGCCGGCGACTGCACCGACCAGCCGCAGTTCGTCTATGTGGCGGCGGCGGCCGGCACGCGCGCCGCGATCAACATGAC
CGGCGGCGACGCGGCGCTGGACCTGACGGCGATGCCGGCGGTGGTGTTCACCGATCCGCAGGTGGCGACCGTGGGCTACA
GCGAGGCGGAAGCGCACCACGACGGCATCGAGACCGACAGCCGGCTGCTGACGCTCGACAACGTGCCGAGGGCGCTCGCC
AACTTCGACACGCGCGGCTTCATCAAGCTGGTGGCGGAAGCTGGCTCAGGGCGGCTGATCGGCGTACAGGCGGTCGCGCC
GGAAGCGGGCGAACTGATCCAGACGGCCGCGCTGGCGATCCGCCACCGGATGACCGTGCAGGAGCTGGCCGACCAGTTGT
TCCCCTACCTGACCATGGTCGAGGGACTGAAGCTCGCGGCGCAGACCTTCAACAAGGACGTGAAGCAACTGTCCTGTTGC
GCCGGATGA

Protein sequence : 
MAEAITLHIEGMTCTSCAEHVQQALTNVPGVRAASVSYPQRQAEIEADAGVSVAPLVAAVATLGYRARLTDTPNKPAGLL
DKALGWLGGETKHVGGEQALHVAVIGSGGAAMAAALKAVEQGARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIVHLRRE
SPFDAGLPAAAPAVLRERLLAQQQGRVEELRHAKYEGILASTPAITVLRGEARFRDTRTLTVATADGGTHEVNFDRCLIA
TGASPALPPIPGLADTPHWTSTEALESSSLPERLAVIGSSVVAVELAQAFARLGSQVTILARSTLFFREDPAIGEAVTDA
FRAEGIEVLDHTQASHVAYAGGEFVLTTGQGEVRADKLLVATGRAPNTRSLNLEAAGVEVNAQGAIVIDRAMRTSAPHIF
AAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRLLTLDNVPRALA
NFDTRGFIKLVAEAGSGRLIGVQAVAPEAGELIQTAALAIRHRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCC
AG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 0.0 100
merA ABQ57371.1 MerA Not tested SGI1 Protein 0.0 80
merA AGK07021.1 MerA Not tested SGI1 Protein 0.0 80
merA AGK07079.1 MerA Not tested SGI1 Protein 0.0 80
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 0.0 80
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 0.0 80
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 0.0 79
merA AFG30120.1 MerA Not tested PAGI-2 Protein 0.0 79
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 0.0 79
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 0.0 77
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 2e-87 41
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 2e-87 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_003977131.1 mercuric reductase BAC0653 Protein 0.0 82
merA YP_003977131.1 mercuric reductase BAC0652 Protein 0.0 79
merA YP_003977131.1 mercuric reductase BAC0650 Protein 9e-180 70
merA YP_003977131.1 mercuric reductase BAC0224 Protein 2e-85 42
merA YP_003977131.1 mercuric reductase BAC0651 Protein 1e-87 41